A5044860377- Aortic Disease and Treatment Approaches
- Cardiac Valve Diseases and Treatments
- Aortic aneurysm repair treatments
- Infective Endocarditis Diagnosis and Management
- Cardiac Structural Anomalies and Repair
- Infectious Aortic and Vascular Conditions
- Astrophysics and Cosmic Phenomena
- Dark Matter and Cosmic Phenomena
- Cardiac, Anesthesia and Surgical Outcomes
- Congenital Heart Disease Studies
- Cardiac and Coronary Surgery Techniques
- Cardiovascular Function and Risk Factors
- Mechanical Circulatory Support Devices
- Tracheal and airway disorders
- Lung Cancer Diagnosis and Treatment
- Neutrino Physics Research
- Esophageal and GI Pathology
- Gamma-ray bursts and supernovae
- Cardiac tumors and thrombi
- Particle Detector Development and Performance
- Tissue Engineering and Regenerative Medicine
- Vascular Procedures and Complications
- Cardiac pacing and defibrillation studies
- Aortic Thrombus and Embolism
- Cardiac Imaging and Diagnostics
Keio University
2016-2025
Japan Surgical Society
2025
Jikei University School of Medicine
2025
Toho University Medical Center Sakura Hospital
2017-2023
Toho University
2017-2023
Kyoto University
1993-2023
Fukushima Medical University
2023
Hamamatsu University School of Medicine
2023
Fujita Health University
2023
Japan Organization for Metals and Energy Security (Japan)
2023
The semiquantitative Clinical Frailty Scale (CFS) is a simple tool to assess patients' frailty and has been shown correlate with mortality in elderly patients even when evaluated by nongeriatricians. aim of the current study was determine prognostic value CFS who underwent transcatheter aortic valve replacement.We utilized OCEAN (Optimized Catheter Valvular Intervention) Japanese multicenter registry review data 1215 replacement. Patients were categorized into 5 groups based on stages: 1-3,...
Background— Acute aortic dissection (AAD) is a life-threatening vascular disease without effective pharmaceutical therapy. Matrix metalloproteinases (MMPs) are implicated in the development of chronic diseases including aneurysm, but key effectors and mechanism action remain unknown. To define further role MMPs AAD, we screened circulating AAD patients, then generated novel mouse model for to characterize action. Methods Results— MMP9 angiotensin II were elevated significantly blood samples...
We reviewed the results of endovascular aneurysm repair in patients from Japanese Committee for Stentgraft Management registry to determine significance persistent type II endoleak (p-T2EL) and risk late adverse events, including sac enlargement.The prospectively captured medical records 17 099 <75 years age who underwent abdominal aortic 2006 2015 were reviewed. Patients divided into 2 groups (with or without p-T2EL) compared examine correlation between p-T2EL occurrence enlargement after...
Abstract We present a near-infrared ($JHK_{\rm s}$) photometric catalog, including 14811185 point sources for 40 deg$^2$ area of the Large Magellanic Cloud, 2769682 an 11 Small and 434145 4 Bridge. The 10$\sigma$ limiting magnitudes are 18.8, 17.8, 16.6 mag at $J, H$, $K_{\rm s}$, respectively. astrometric accuracies bright 0.03–0.04 0$\rlap {.}{^{\prime\prime}}$1, Based on we also (1) spatial distributions, (2) luminosity functions, (3) color–color diagrams, (4) color–magnitude diagrams...
Background: The occurrence and clinical impact of untreated subclinical leaflet thrombosis beyond 1 year after transcatheter aortic valve replacement still remain unclear. Methods Results: In a multicenter registry, we analyzed data from 485 patients who underwent 4-dimensional multidetector computed tomography posttranscatheter performed to survey hypoattenuated thickening with reduced motion compatible thrombus at median 3 days, 6 months, year, 2 years, years. Incidence, predictors,...
One of the final treatments for end-stage heart failure is transplantation. However, a shortage donor hearts has created long waiting list and limited benefits. Our ultimate goal to create whole beating fabricated on an organ scaffold human Here, we successfully performed first transplantation using decellularized porcine with mesenchymal stem cells. A was harvested following cardiac arrest induced by high-potassium solution stored at −80°C 24 h. The completely 1% sodium dodecyl sulphate...
The severe shortage of donor hearts hampered the cardiac transplantation to patients with advanced heart failure. Therefore, regenerative therapies are eagerly awaited as a substitution. Human induced pluripotent stem cells (hiPSCs) realistic cell source for cardiomyocytes. hiPSC-derived cardiomyocytes highly expected help recovery heart. Avoidance teratoma formation and large-scale culture definitely necessary clinical setting. combination pure spheroids gelatin hydrogel succeeded recover...
Increased angiogenesis, chronic inflammation, and extracellular matrix degradation are the major pathological features of abdominal aortic aneurysm (AAA). We sought to elucidate role vascular endothelial growth factor (VEGF)-A, a potent angiogenic proinflammatory factor, in development AAA. Human AAA samples showed increased VEGF-A expression, neovascularization, macrophage infiltration compared with normal walls. was induced mice by periaortic application CaCl2. were treated soluble...
To compare safety, efficacy, and hemodynamics of transfemoral transcatheter aortic valve replacement (TAVR) using self-expanding balloon-expandable heart valves (THVs) in patients with a small annulus.Few studies have directly compared TAVR outcomes third-generation THVs, focusing on annuli.In multicenter registry, we analyzed data from 576 annulus who underwent THVs. Propensity score matching was used to adjust baseline clinical characteristics.The device success rate the overall cohort...
Engineered heart tissues (EHTs) that are fabricated using human induced pluripotent stem cells (hiPSCs) have been considered as potential cardiac tissue substitutes in case of failure. In the present study, we created hiPSC-derived organoids (hiPSC-COs) comprised cardiomyocytes, umbilical vein endothelial cells, and fibroblasts. To produce a beating conduit for patients suffering from congenital diseases, constructed scaffold-free tubular EHTs (T-EHTs) hiPSC-COs bio-3D printing with needle...
We performed a multicenter prospective comparative study to determine the impact of Japanese frozen elephant trunk device on total arch replacement compared with conventional repair without it.Between 2016 and 2019, 684 patients (frozen procedure; n = 369; repair, 315) from 41 institutions were enrolled. The 2 procedures selected according each center's strategy.The procedure was applied more for aortic dissection, whereas repairs predominantly aneurysms. In former, only hypothermic...
Background The practice pattern and outcome of medical devices following their regulatory approval may differ by country. aim this study is to compare postapproval national clinical registry data on transcatheter aortic valve replacement between the United States Japan patient characteristics, periprocedural outcomes, variability outcomes as a part partnership program (Harmonization-by-Doing) 2 countries. Methods Results patient-level were extracted from US Society Thoracic Surgeons...