A5025644755- Cardiac Structural Anomalies and Repair
- Aortic Disease and Treatment Approaches
- Cardiac Valve Diseases and Treatments
- Mechanical Circulatory Support Devices
- Connective tissue disorders research
- Aortic aneurysm repair treatments
- Transplantation: Methods and Outcomes
- Infective Endocarditis Diagnosis and Management
- Cardiac, Anesthesia and Surgical Outcomes
- Infectious Aortic and Vascular Conditions
- Congenital Heart Disease Studies
- Cardiac Arrest and Resuscitation
- Cardiovascular Function and Risk Factors
- Cardiac and Coronary Surgery Techniques
- Cardiovascular Issues in Pregnancy
- Renal and Vascular Pathologies
- Medical Imaging and Pathology Studies
- Orthopaedic implants and arthroplasty
- Cardiac pacing and defibrillation studies
- Esophageal and GI Pathology
- Fuel Cells and Related Materials
- Viral Infections and Immunology Research
- Hepatitis Viruses Studies and Epidemiology
- Asthma and respiratory diseases
- Tracheal and airway disorders
The University of Tokyo
2016-2025
University of Tokyo Hospital
2016-2025
Japanese Circulation Society
2023
Society for Vascular Surgery
2023
Katsushika Medical Center
2021
Yamaguchi University Hospital
2021
Boston Children's Hospital
2012-2017
Harvard University
2012-2017
Boston Children's Museum
2011-2012
Mitsui Memorial Hospital
2009-2010
Recent reports suggest the involvement of vascular phenomena in exercise-induced asthma. Sensory neuropeptides, such as substance P (SP), which causes airway dilatation and plasma leakage, have been demonstrated to play a role hyperpnea-induced narrowing animal studies. The purpose this study was investigate importance tachykinins patients with asthma using selective neurokinin 1-receptor (NK1-receptor) antagonist, FK-888. In double-blind, placebo-controlled, crossover trial, nine subjects...
Marfan syndrome can cause life-threatening aortic complications. We investigated the relationship between FBN1 genotype and severe aortopathy (aortic root replacement, type A dissections, related death).We evaluated 248 patients with pathogenic or likely variants. The variants were classified as haploinsufficient (HI, n=93) dominant-negative (DN, n=155) based on their location predicted amino acid alterations, we examined effects of events death).The cumulative event-free probability was...
Accurate morphological information on aortic valve cusps is critical in treatment planning. Image segmentation necessary to acquire this information, but manual tedious and time consuming. In paper, we propose a fully automatic method from CT images by combining two deep neural networks, spatial configuration-Net for detecting anatomical landmarks U-Net of components. A total 258 volumes end systolic diastolic phases, which include cases with without severe calcifications, were collected...
BACKGROUND: Marfan syndrome (MFS) is an inherited disorder caused by mutations in the FBN1 gene encoding fibrillin-1, a matrix component of extracellular microfibrils. The main cause morbidity and mortality MFS thoracic aortic aneurysm dissection, but underlying mechanisms remain undetermined. METHODS: To elucidate role endothelial XOR (xanthine oxidoreductase)–derived reactive oxygen species progression, we inhibited vivo function either cell (EC)–specific disruption Xdh or systemic...
Heart transplantation (HT) is an effective therapeutic option for end-stage heart failure. Infection a major cause of morbidity and mortality after HT. Sarcopenia, defined as the loss muscle mass strength, common comorbidity in HT candidates with However, effects sarcopenia on occurrence post-HT infections are not well understood. Therefore, we explored association between skeletal post-transplant adult recipients.We retrospectively examined records 135 patients who underwent August 2007...
Beating-heart image-guided intracardiac interventions have been evolving rapidly. To extend the domain of catheter-based and transcardiac into reconstructive surgery, a new robotic tool delivery platform tissue approximation device developed. Initial results using these tools to perform patent foramen ovale closure are described.A comprising superelastic metal tubes provides capability delivering manipulating devices inside beating heart. A technology is also presented that uses metal-based...
To investigate pregnancy outcomes, especially the risk of pregnancy-related aortic dissection (AD), in patients with Marfan syndrome (MFS) after prophylactic root replacement (ARR).Retrospective case series study.Tertiary perinatal care centre at a university hospital.Pregnant women fulfilling revised Ghent nosology (2010) criteria for MFS who were managed our institute.The outcomes all institute between 1982 and September 2016 reviewed retrospectively based on medical records.Obstetrical...
Background We aimed to develop a simple structural model of aortic aneurysms using computer‐assisted drafting ( CAD ) in order create basis definition for saccular aneurysms. Methods and Results constructed aneurysm with 2 components: tube similar an aorta ellipse analogous bulging aneurysm. Three parameters, including the vertical horizontal diameters fillet radius, were altered model. Using analysis finite element method, we visualized distribution maximum principal stress MPS wall...
Desminopathy is a cardiac and skeletal myopathy caused by disease-causing variants in the desmin (DES) gene represents subgroup of myofibrillar myopathies, where cytoplasmic desmin-postive immunoreactivity pathological hallmark. We herein report 28-year-old Japanese man who was initially diagnosed with sporadic hypertrophic cardiomyopathy atrioventricular block at 9 years old developed weakness soft palate extremities. The myocardial tissue dissected during implantation ventricular-assisted...
BACKGROUND It is widely accepted that Point‐of Care Test (PoCT) devices are useful in the detection of coagulopathies situations massive bleeding such as major cardiac surgery. These contribute to reduction blood transfusion. However, their implementation remains limited Japan because cost and lack health insurance support. STUDY DESIGN AND METHODS Conventional coagulation tests thromboelastography (TEG)/Sonoclot values were measured 50 consecutive surgery cases. Clinical background...
Among the several musculoskeletal manifestations in patients with Marfan syndrome, spinal deformity causes pain and respiratory impairment is a great hindrance to patients' daily activities. The present study elucidates genetic risk factors for development of severe scoliosis syndrome.We retrospectively evaluated 278 pathogenic or likely FBN1 variants. were divided into those (n=57) without (n=221) scoliosis. Severe was defined as (1) undergoing surgery before 50 years age (2) Cobb angle...
Polytetrafluoroethylene (PTFE) is widely used in cardiovascular surgeries; however, postoperative complications such as thrombosis, calcification, and neointimal hyperplasia are yet to be resolved patients. We developed two types of novel knitted PTFE patches evaluated them using a swine model. Both were composed impregnated with micro-PTFE particles, one was pressed after impregnation. Twenty micromini pigs this study. After left lateral thoracotomy, the new (n = 8 for each type patch)...
Mechanisms and treatments of nonischemic functional mitral regurgitation (NIMR) are not fully established, in part, because a lack proper large animal models. We developed novel technique NIMR creation swine model by making multiple small incisions the annulus.Ex vivo experiments using isolated hearts (n=10) showed 15% increase annular area (6.8-7.8 cm(2)) after 16 were made along posterior annulus pressurized left ventricle. In an (n=7; 46.4 ± 2.2 kg), was created fourteen to twenty-six...