A5101982694- Pregnancy and preeclampsia studies
- Reproductive System and Pregnancy
- 3D Printing in Biomedical Research
- Birth, Development, and Health
- Microfluidic and Bio-sensing Technologies
- Microbial Metabolic Engineering and Bioproduction
- Endometriosis Research and Treatment
- Reproductive Biology and Fertility
- Innovative Microfluidic and Catalytic Techniques Innovation
- Pregnancy and Medication Impact
- Microfluidic and Capillary Electrophoresis Applications
- Preterm Birth and Chorioamnionitis
- Ectopic Pregnancy Diagnosis and Management
- Pregnancy-related medical research
- Immunotoxicology and immune responses
- Porphyrin and Phthalocyanine Chemistry
- Video Coding and Compression Technologies
- Pancreatic function and diabetes
- Erythrocyte Function and Pathophysiology
- Cardiovascular Issues in Pregnancy
- Neonatal Respiratory Health Research
- Wastewater Treatment and Nitrogen Removal
- Congenital Heart Disease Studies
- Sphingolipid Metabolism and Signaling
- Image and Video Quality Assessment
The University of Tokyo
2014-2023
National Center For Child Health and Development
2023
University of Tokyo Hospital
2011-2021
Hiroshima University
2021
National Institute for Japanese Language and Linguistics
2021
NTT (Japan)
2002-2013
Self-Defense Forces Central Hospital
1996-2012
Niigata University
2010
Tohoku University
2010
Nippon Medical School
2007
The HLA-G primary transcript is alternatively spliced to yield mRNAs encoding three alternative membrane bound proteins. In addition these forms, a soluble protein has been described which not encoded directly by any of the mRNAs. To explain process might lead expression Ag, we investigated potential roles proteolytic processing and additional splicing RNA play. By generating transfected cells with cDNA driven retroviral promoter, it was possible rule out membrane-bound as mechanism HLA-G,...
We have developed a very controllable fabrication process of an extremely narrow (∼10 nm) quantum wire metal-oxide-semiconductor field-effect transistor (MOSFET) on separation-by-implanted-oxygen (SIMOX) substrate using anisotropic etching and selective oxidation technique. The drain current versus gate voltage characteristics show oscillations caused by Coulomb blockade even at room temperature. split into several sharp peaks when the temperature is decreased, indicating that channel...
A novel ethylene-forming enzyme that catalyses the formation of ethylene from 2-oxoglutarate was purified a cell-free extract Pseudomonas syringae pv. phaseolicola PK2. It about 2800-fold with an overall yield 53% to single band protein after SDS-PAGE. The had specific activity 660 nmol min–1 (mg protein)–1. molecular mass approximately 36 kDa by gel filtration and 42 isoelectric point optimum pH were 5·9 ca. 7·0–7·5 respectively. There no homology between N-terminal amino acid sequence Ps....
Endometriosis has been shown to be associated with second- third-trimester pregnancy complications such as preterm birth and placenta previa, but the evidence is inconsistent. We hypothesized that endometriosis severity might affect these inconsistent results. Therefore we aimed conduct a retrospective cohort study elucidate whether incidence rates of adverse outcomes. The patients who achieved singleton by assisted reproductive technology (ART) in our facility between March 2000 December...
Single-stage Nitrogen removal using Anammox and Partial nitritation (SNAP) process was newly developed as an economical nitrogen for ammonium rich wastewaters. The experimental studies the evaluation of SNAP were carried out a novel biofilm reactor, in which hydrophilic net-type acryl fiber biomass carrier applied. This reactor operated under operational conditions pH 7.5–7.7, 35 °C DO 2–3 mg/L, 60 to 80% influent NH4-N removed loading rate 0.48 kg-N/m3/d. Through DNA analysis attached...
Abstract Placental growth factor (PlGF), abundantly produced from trophoblasts is involved in placental angiogenesis. The regulatory mechanism of its expression poorly understood. Hypoxia inducible factors (HIFs) are centrally the modulation cellular function response to low oxygen conditions. This study aimed clarify HIF1α and HIF2α patterns during cytotrophoblast differentiation into syncytiotrophoblast impact any changes on PlGF expression. HIF proteins were induced remarkably under...
Cephalopagus twinning, an extremely rare type of conjoined twins, is characterized by the anterior union upper half body, with two faces each situated on opposite side a head. The prognosis for cephalopagus twins poor because surgical separation not option. Thus early prenatal diagnosis important to provide opportunity pregnancy termination if desired. However, in many instances, are misdiagnosed as singleton extreme degree fusion which makes accurate demonstration abnormalities very...
To investigate pregnancy outcomes, especially the risk of pregnancy-related aortic dissection (AD), in patients with Marfan syndrome (MFS) after prophylactic root replacement (ARR).Retrospective case series study.Tertiary perinatal care centre at a university hospital.Pregnant women fulfilling revised Ghent nosology (2010) criteria for MFS who were managed our institute.The outcomes all institute between 1982 and September 2016 reviewed retrospectively based on medical records.Obstetrical...
This study aimed to investigate the association of Th1/Th2 polarity induced by CD1d-restricted invariant natural killer T (iNKT) cells with pregnancy outcome.Two types iNKT cell stimulants different cytokine induction properties, alpha-galactosylceramide (AGC; Th1-biased inducer), and a sphingosine-truncated derivative AGC (OCH; Th2-biased inducer) were administered pregnant mice on day 9.5 post-coitus (pc), incidence loss was evaluated. Serum levels after stimulations assessed. Cytokine...
Although adenomyosis is reportedly associated with adverse pregnancy outcomes, clinical factors related to the high risk of obstetric complications are unclear. This study aimed elucidate characteristics lesions increased incidence based on imaging findings.This was a retrospective, observational cohort conducted in tertiary perinatal care center. Eighty-eight singleton pregnant women were included study. Based magnetic resonance or ultrasonography before and/or during pregnancy, patients...
A polymer (PDMS: poly(dimethylsiloxane)) microchip for capillary gel electrophoresis that can separate different sizes of DNA molecules in a small experimental scale is presented. This be easily produced by simple PDMS molding method against microfabricated master without the use elaborate bonding processes. could used as single device unlike conventional microchips made glass, quartz or silicon. The channel on chip was partially filled with agarose enhance separation resolution and shorten...
Several analytical methods have been developed to measure the lignin content corresponding different plant species and regions. The sulphuric acid method is commonly used for objective determinations of using near-infrared spectroscopy. Lignin a complex polymer units. types ratios units vary among taxonomic classes plants. To compare as determined by chemical analysis, fallen leaves were analysed both detergent acetyl bromide procedures. Near-infrared reflectance spectra obtained each sample...
High hydrostatic pressure (HP) with approximately below 400 MPa can induce a transformation of food materials to an alternative form, where membrane systems are damaged but certain enzymes still active. HP treatment water soaked brown rice grain could modify the mass transfer inside and apparent activities enzymes, resulting in HP-dependent change distribution free amino acids. Thus, acids during preservation after was analyzed. Just at 200 for 10 min, not apparently different from that...
Summary: A system was developed for the formation of ethylene in vitro by an extract Pseudomonas syringae pv. phaseolicola PK2. The ethylene-forming activity a cell-free this bacterium measured reported previously almost completely lost when dialysed against potassium phosphate buffer 24 h at 4 °C. When fraction with molecular mass < 10 kDa (SupI) added back to enzyme after gel filtration extract, enzymic increased about four times that gel-filtered crude enzyme. action SupI could be...
In multicellular organisms, precise control of cell cycle and the maintenance genomic stability are crucial to prevent chromosomal alterations. The accurate function DNA damage pathway is maintained by repair mechanisms including homologous recombination (HR). Herein, we show that both TFII-I DBC1 mediate cellular cell-cycle regulation double strand repair. Regulation was investigated using Trypan blue dye exclusion test, luciferase assay, flow cytometry analysis. We also analysed role in...
Objective Tokishakuyakusan ( TSS ) is a traditional herbal medicine that has been used empirically to prevent recurrent pregnancy loss. Its mode of action remains unclear. With their potent capacity produce cytokines, invariant natural killer iNKT cells are involved in the control fetomaternal immunity early gestation. This study aimed clarify effect on cell activities well‐studied murine miscarriage model. Methods Pregnant mice were fed 1% ‐containing or diet from day vaginal plug...
Journal Article Cytochrome P450rm from Rhodotorula minuta Catalyzes 4-Hydroxylation of Benzoate Get access Hideo Fukuda, Fukuda 1 Department Applied Microbial Technology, The Kumamoto Institute Technology4-22-1 Ikeda, 860 1To whom correspondence should be addressed. Search for other works by this author on: Oxford Academic PubMed Google Scholar Kiminori Nakamura, Nakamura Eiki Sukita, Sukita Takahira Ogawa, Ogawa Takao Fujii Biochemistry, Volume 119, Issue 2, February 1996, Pages 314–318,...
Abstract Problem Recent advances in lipid research have revealed that impairments mediator signaling can be involved the pathoetiology of a variety diseases. We previously reported aberrant expression autotaxin, key enzyme for lysophosphatidic acid (LPA) production, placentas from women with preeclampsia. The present study aimed to further explore involvement LPA Method Term were obtained deliveries after uncomplicated pregnancy (n = 18) and those complicated by preeclampsia 24)....