Seisuke Sayama

ORCID: 0000-0003-0244-6332
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About
Contact & Profiles
Research Areas
  • Pregnancy and preeclampsia studies
  • Endometriosis Research and Treatment
  • Reproductive System and Pregnancy
  • Pregnancy-related medical research
  • Maternal and fetal healthcare
  • Birth, Development, and Health
  • Uterine Myomas and Treatments
  • Cardiovascular Issues in Pregnancy
  • Preterm Birth and Chorioamnionitis
  • Epigenetics and DNA Methylation
  • Gestational Diabetes Research and Management
  • Ectopic Pregnancy Diagnosis and Management
  • Maternal and Perinatal Health Interventions
  • Connective tissue disorders research
  • Neonatal Respiratory Health Research
  • Aortic Disease and Treatment Approaches
  • Assisted Reproductive Technology and Twin Pregnancy
  • Congenital Heart Disease Studies
  • Crystallization and Solubility Studies
  • X-ray Diffraction in Crystallography
  • Pregnancy and Medication Impact
  • Congenital Diaphragmatic Hernia Studies
  • Prenatal Screening and Diagnostics
  • Blood Coagulation and Thrombosis Mechanisms
  • Adenosine and Purinergic Signaling

The University of Tokyo
2013-2025

Tokyo-Kita Medical Center
2024

University of Tokyo Hospital
2021-2023

The University of Texas Health Science Center at Houston
2020

Bunkyo University
2019

To evaluate the potential impact of adenomyosis on pregnancy outcomes by retrospectively investigating adenomyosis-complicated cases.We performed a retrospective case-control study. Forty-nine singleton cases complicated with were included in this The controls (n = 245) pregnant women without and frequency matched to age, parity, need for assisted reproductive technology conception. incidence obstetrical complications delivery neonatal examined.Patients group significantly more likely have...

10.1080/14767058.2017.1285895 article EN The Journal of Maternal-Fetal & Neonatal Medicine 2017-01-23

Adenomyomectomy, a therapeutic option for women with adenomyosis who wish to preserve their fertility, has been reported pose risk of developing placenta accreta spectrum (PAS) and uterine rupture in future pregnancies. However, the specific clinical factors contributing these occurrences remain elusive. This study aimed explore association between hysteroscopic findings after adenomyomectomy incidence PAS subsequent We conducted retrospective analysis 10 patients (11 pregnancies) had...

10.1007/s43032-024-01758-7 article EN cc-by Reproductive Sciences 2025-01-06

Recent evidence indicates that elevated placental adenosine signaling contributes to preeclampsia (PE). However, the molecular basis for chronically enhanced in PE remains unclear. Here, we report hypoxia-inducible factor-1α (HIF-1α) is crucial enhancement of signaling. Utilizing a pharmacologic approach reduce levels, found underlies increased HIF-1α an angiotensin receptor type 1 agonistic autoantibody (AT1 -AA)-induced mouse model PE. Knockdown vivo suppressed accumulation and...

10.1096/fj.201902583r article EN publisher-specific-oa The FASEB Journal 2020-01-12

To investigate pregnancy outcomes, especially the risk of pregnancy-related aortic dissection (AD), in patients with Marfan syndrome (MFS) after prophylactic root replacement (ARR).Retrospective case series study.Tertiary perinatal care centre at a university hospital.Pregnant women fulfilling revised Ghent nosology (2010) criteria for MFS who were managed our institute.The outcomes all institute between 1982 and September 2016 reviewed retrospectively based on medical records.Obstetrical...

10.1111/1471-0528.14635 article EN BJOG An International Journal of Obstetrics & Gynaecology 2017-03-11

Problem Elafin and secretory leukocyte peptidase inhibitor (SLPI) are unique among antimicrobial peptides (AMPs). This study aimed to determine the expression levels of these AMPs at cervix during pregnancy investigate their association with preterm labor. Method Cervical epithelial cells were swabbed from normal pregnant women evaluate physiological elafin SLPI. Cross-sectional analysis was conducted compare cervical for SLPI three women's groups, controls (n = 26), threatened labor who...

10.1111/aji.12354 article EN American Journal of Reproductive Immunology 2015-01-05

Insufficient O2 supply is frequently associated with fetal growth restriction (FGR), a leading cause of perinatal mortality and morbidity. Although the erythrocyte most abundant only cell type to deliver in our body, its function regulatory mechanism FGR remain unknown. Here, we report that genetic ablation mouse equilibrative nucleoside transporter 1 (eENT1) dams, but not placentas or fetuses, results FGR. Unbiased high-throughput metabolic profiling coupled vitro vivo flux analyses...

10.1172/jci.insight.130205 article EN cc-by JCI Insight 2020-05-20

Although adenomyosis is reportedly associated with adverse pregnancy outcomes, clinical factors related to the high risk of obstetric complications are unclear. This study aimed elucidate characteristics lesions increased incidence based on imaging findings.This was a retrospective, observational cohort conducted in tertiary perinatal care center. Eighty-eight singleton pregnant women were included study. Based magnetic resonance or ultrasonography before and/or during pregnancy, patients...

10.1080/14767058.2023.2226789 article EN cc-by The Journal of Maternal-Fetal & Neonatal Medicine 2023-06-25

Abstract Pravastatin is a promising medication to treat preeclampsia. However, the appropriate dose of pravastatin for managing preeclampsia has not been established. In this in vitro study, we examined effects low concentrations (0.01 10 µM) under hypoxic conditions on two types placental cells and found that decreased sFlt-1 levels up 34% cytotrophoblast isolated from human term placentas. Furthermore, showed HTR-8/SVneo cells, cell line derived first trimester trophoblast after exposure...

10.1007/s43032-024-01611-x article EN cc-by Reproductive Sciences 2024-06-05

Additional risk factors for preterm delivery in pregnant women with cervical shortening are not fully understood; however, mid-trimester is accepted as a factor delivery. This study aimed to identify associated subsequent among patients short cervix detected after late mid-trimester. was retrospective of medical data from single perinatal tertiary facility. We identified 134 asymptomatic singleton pregnancies where (≤25 mm) during routine universal screening at 22–33 weeks. Statistical...

10.1016/j.tjog.2020.01.005 article EN cc-by-nc-nd Taiwanese Journal of Obstetrics and Gynecology 2020-03-01

Objectives: To investigate the spontaneous outcomes of vascularized retained products conception (RPOC) detected by ultrasonography after second-trimester abortion, and to identify predictive factors for development severe postpartum hemorrhage (SPPH).Study design: This is a retrospective cohort study on all cases abortion managed at our institute between January 2014 December 2016. We assessed associations occurrence SPPH requiring invasive treatment clinical including ultrasonographic...

10.1080/14767058.2019.1610739 article EN The Journal of Maternal-Fetal & Neonatal Medicine 2019-04-22

Adenomyosis is associated with unfavorable perinatal outcomes; however, the effect of an adenomyomectomy on pregnancy outcomes remains unclear. Pregnancy following has been reported to be a high risk for uterine rupture; actual incidence unknown.

10.1016/j.xagr.2023.100265 article EN cc-by-nc-nd AJOG Global Reports 2023-09-01

mRNA vaccination is an effective, safe, and widespread strategy for protecting pregnant women against infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. However, information on factors such as perinatal outcomes, safety, coverage of vaccinations among limited in Japan. Therefore, this study aimed to investigate the coverage, adverse effects, short-term safety well vaccine hesitancy women.We conducted a multicenter online survey postpartum who delivered...

10.1186/s12884-023-05669-4 article EN cc-by BMC Pregnancy and Childbirth 2023-05-09

Abstract Hydatidiform moles are known to pose an extremely high risk of severe early-onset preeclampsia if left untreated. TNF superfamily cytokine, LIGHT has recently been reported contribute pathophysiology preeclampsia. The present study aimed investigate the involvement in hydatidiform moles. We measured serum levels and sFlt-1 by ELISA 17 women with complete mole (HM) 20 gestational-age-matched normal pregnant (control). As a result, were significantly higher HM as compared those...

10.1038/s41598-019-46660-4 article EN cc-by Scientific Reports 2019-07-12

Citation Iwasawa Y, Kawana K, Fujii T, Schust DJ, Nagamatsu Sayama S, Miura Matsumoto J, Adachi Hyodo H, Yamashita Kozuma Taketani Y. A possible coagulation‐independent mechanism for pregnancy loss involving β 2 glycoprotein 1‐dependent antiphospholipid antibodies and CD1d. Am J Reprod Immunol 2012; 67: 54–65 Problem glycoprotein1 (β GP1)‐dependent (aPL) increase the risk recurrent loss. We address whether anti‐β GP1 can interact with phosphatidylserine (PS)‐bearing CD1d on trophoblast cells...

10.1111/j.1600-0897.2011.01028.x article EN American Journal of Reproductive Immunology 2011-06-20

Endometriosis and adenomyosis not only cause symptoms such as dysmenorrhea, chronic pelvic pain, infertility, but have also recently been implicated in a range of obstetric complications. The association between endometriosis adverse pregnancy outcomes has developing new topic the field reproductive medicine over past few years. This review aims to summarize detail latest evidence on incidence complications associated with or discuss possible underlying pathophysiological mechanisms.

10.14390/jsshp.hrp2019-015 article EN Hypertension Research in Pregnancy 2019-11-07

Abstract It is widely accepted that enhanced uterine inflammation associated with microbial infection a main causative factor for preterm birth. However, little known about the molecular basis by which Here, we demonstrate apoptosis signal-regulating kinase 1 (ASK1), member of mitogen-activated protein 3-kinase family, facilitates inflammation-induced birth and inhibition ASK1 activity sufficient to suppress ASK1-deficient pregnant mice exhibited reduced incidence lipopolysaccharide...

10.1038/s41598-020-58653-9 article EN cc-by Scientific Reports 2020-02-05

Abstract Aim We aimed to investigate the associations of endometriosis and adenomyosis with pregnancy complications by using a large‐scale Japanese database. Methods retrospectively analyzed 145 590 singleton pregnancies from Japan Perinatal Registry Network Database. Pregnant women registered as having or were designated case group (EA), whereas control (non‐EA) was selected propensity‐score matching adjusted for variables such age, parity, BMI, smoking history, use assisted reproductive...

10.1111/jog.15849 article EN cc-by-nc-nd Journal of Obstetrics and Gynaecology Research 2023-12-10

Uterine fibroids are known to degenerate during pregnancy, but it is unknown if similar pathologic condition occurs in adenomyosis. A 38-year-old para 1 woman exhibited uterine tenderness and a markedly elevated inflammatory response at 22 weeks of gestation. Based on magnetic resonance imaging (MRI) findings indicative hemorrhagic components an adenomyosis lesion, we judged these features resulted from degeneration after excluding the possibility underlying infection by amniocentesis....

10.1111/jog.15195 article EN Journal of Obstetrics and Gynaecology Research 2022-02-16

We aimed to assess the impact of fetal growth restriction (FGR) as a diagnostic criterion for preeclampsia (PE) on severity maternal preeclamptic features by comparing it with other criteria PE, organ dysfunction.We performed retrospective cohort study singleton pregnancies. Based status at diagnosis, PE cases preceded FGR without dysfunction (Group F; n = 28) and those M; 87) were analyzed.Group F had an earlier diagnosis (32.5 ± 4.9 vs. 36.7 3.5 weeks, p < 0.01) delivery (33.7 4.5 37.5 3.1...

10.1111/jog.15152 article EN Journal of Obstetrics and Gynaecology Research 2022-03-03

Uterine necrosis is a rare complication in uterine artery embolization (UAE) for postpartum hemorrhage (PPH). Preeclampsia (PE) condition characterized with systemic endothelial damage and intravascular volume depletion. Whether patient PE at high risk after UAE PPH has been unknown. A 30-year-old primipara woman was diagnosed based on hypertension proteinuria during delivery. performed forceps After UAE, the presented pleural effusion massive ascites as well persistent fever unresponsive to...

10.1155/2022/2859766 article EN cc-by Case Reports in Obstetrics and Gynecology 2022-05-17

Cryoprecipitate (CRYO) is a concentrated preparation of coagulation factors formulated from fresh frozen plasma (FFP), which can replenish rapidly. Preeclampsia (PE) frequently associated with postpartum hemorrhage (PPH), and the rapid replenishment vital in management. We conducted retrospective cohort study to determine efficacy administering CRYO irrespective fibrinogen levels patients PE who experienced severe PPH.Patients PPH accompanied by those required red blood cell (RBC)...

10.1111/jog.15792 article EN Journal of Obstetrics and Gynaecology Research 2023-09-18
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