A5002290354- Prenatal Screening and Diagnostics
- Ectopic Pregnancy Diagnosis and Management
- Alkaline Phosphatase Research Studies
- Neurogenetic and Muscular Disorders Research
- Pregnancy and preeclampsia studies
- Selenium in Biological Systems
- Maternal and fetal healthcare
- COVID-19 and healthcare impacts
- Biochemical and Molecular Research
- Genomic variations and chromosomal abnormalities
- Chromosomal and Genetic Variations
- Heterotopic Ossification and Related Conditions
- Gestational Trophoblastic Disease Studies
- Assisted Reproductive Technology and Twin Pregnancy
- Fetal and Pediatric Neurological Disorders
- Telemedicine and Telehealth Implementation
- Vascular Malformations and Hemangiomas
- Hospital Admissions and Outcomes
- Lung Cancer Research Studies
- Cerebrospinal fluid and hydrocephalus
- Congenital Anomalies and Fetal Surgery
- Congenital heart defects research
- Transcranial Magnetic Stimulation Studies
- Vagus Nerve Stimulation Research
- Dermatologic Treatments and Research
Jikei University School of Medicine
2018-2025
The Jikei University Hospital
2023
National Center For Child Health and Development
2019-2023
Seirei Hamamatsu General Hospital
2016-2018
Shimane Prefectural Central Hospital
1997-2006
The University of Tokyo
1997
Determining the differential diagnosis of small scalp cysts identified on a fetus is difficult. In particular, many physicians have difficulty differentiating meningoceles from during prenatal period. Volume contrast imaging increases between tissues, thereby allowing an enhanced view target structures. A 15 × 5 mm cyst was ultrasonography examination performed at 20 weeks gestation. The not connected to blood flow, and did include tissue brain parenchyma. Ventriculomegaly other structural...
High-resolution G- and Q-band patterns of cat (<i>Felis catus</i>) prometaphase chromosomes with more than 450 numbered bands are presented. This number represents approximately twice the per haploid set exhibited by feline at mid-metaphase. A diagrammatic representation G-banded has already been described (O’Brien Nash, 1982); however, precise numbering landmarks, as in human karyotype karyotypes other domestic laboratory animals, not yet available for karyotype, except...
Herein, we present a case of mosaic trisomy 6 detected by amniocentesis. Amniocentesis (G-banding) was performed at 17 weeks gestation; the results were 47,XY,+6[3]/46,XY[12]. Fetal screening ultrasonography showed no morphological abnormalities, and parents desired to continue pregnancy. The infant delivered vaginally 39 weeks' gestation. male weighed 3002 g birth with abnormalities. G-banding karyotype analysis on infant's peripheral blood revealed 46,XY[20]. FISH signals chromosome in 1–4...
In some previous studies, transcutaneous electrical nerve stimulation (TENS) to the back was shown improve non-verbal short-term and long-term memory as well verbal fluency in patients early stage of Alzheimer's disease (AD). Moreover, patients' physical, social affective functions were also improved. this study, effects TENS applied face studied with mild severe AD. Fourteen probable AD used subjects. To evaluate treatment, subjects underwent two kinds neuropsychological tests a pupillary...
mRNA vaccination is an effective, safe, and widespread strategy for protecting pregnant women against infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. However, information on factors such as perinatal outcomes, safety, coverage of vaccinations among limited in Japan. Therefore, this study aimed to investigate the coverage, adverse effects, short-term safety well vaccine hesitancy women.We conducted a multicenter online survey postpartum who delivered...
Hypophosphatasia (HPP) is a congenital disorder caused by mutations in the tissue-nonspecific alkaline phosphatase (TNALP) gene. The pathogenesis of HPP varies, ranging from severe cases which there total absence fetal bone calcification, leads to stillbirth, relatively mild effects are confined teeth, such as early loss primary teeth. In recent years, establishment enzyme supplementation treatment method has prolonged survival patients; however, this approach does not provide sufficient...
Amniotic fluid embolism (AFE) is a rare complication of pregnancy and its mortality rate high. There have been few reports AFE with presence severe coagulopathy incoagulable bleeding, absence cardiopulmonary symptoms or limited symptoms, followed by massive blood loss during delivery. Such cases referred to as disseminated intravascular coagulopathy-type AFE, the characteristics this condition presented previously. Here we report three that fulfilled diagnostic AFE.
Small cell ovarian carcinoma of the pulmonary type is a rare and highly aggressive tumor for which suitable treatment strategy has not been established. A 45-year-old woman presented with abdominal swelling, primary was suspected. The postoperative pathological diagnosis small type. She also had complicated grade 1 endometrioid uterine corpus. Three courses cisplatin etoposide therapy were administered as adjuvant chemotherapy. Because chemotherapy resistant, she underwent palliative...
Hypophosphatasia (HPP) is a congenital skeletal disease. Impairment of bone mineralization and seizures are due to deficiency tissue-nonspecific alkaline phosphatase (TNAP). Enzyme replacement therapy (ERT) available as highly successful treatment for pediatric-onset HPP. However, the potential prenatal ERT has not been fully investigated date. In this study, we assessed outcomes maternal safety using combinational approach with postnatal administration recombinant TNAP in Akp2 -/- mice...
A Breus' mole is a massive subchorionic thrombohematoma that arises below the chorionic plate on fetal side of placenta. It requires careful perinatal management because associated high incidence severe growth restriction and intrauterine demise. However, mechanism its development remains unclear, there are no reports examining continuous changes in hematomas. Herein, we report case which ultrasonographic were observed during pregnancy. 40-year-old pregnant patient presented with...
The patient, a 34-year-old primigravida with no prior medical history, presented at 23 + 0 weeks gestational hypertension and fetal growth restriction (FGR). Ultrasound examination showed placental mass, subsequent repeated ultrasound scans revealed changes in the mass' echogenicity, raising suspicion of massive subchorionic thrombohematoma (MST). While blood pressure was mildly elevated without proteinuria organ dysfunctions, serum soluble fms-like tyrosine kinase-1/placental factor...
Abstract Type 2 spinal muscular atrophy with lower extremity dominance (SMALED2) is caused by bicaudal D cargo adaptor ( BICD2 ) variants. However, the SMALED2 genotype and phenotype correlation have not been thoroughly characterized. We identified de novo heterozygous missense variants in two fetuses severe, prenatally diagnosed multiple arthrogryposis congenita. This report provides further insights into genetics of this rare disease.
Objectives: To investigate the association between online activities and number of new obstetrics gynecology senior residents.Methods: A nationwide web-based, self-administered anonymous survey was conducted to recruitment clerkship during coronavirus disease 2019 pandemic.An questionnaire sent 576 training institutions in Japan December 21, 2020, January 31, 2021.Overall, 334 that gave valid responses were included (response rate: 58.0%).Multivariate logistic regression analysis examined...
The clinical courses including thyroid conditions of three infants born to a mother with primary hypothyroidism due Hashimoto's thyroiditis were studied. was positive for both TSH-binding inhibitor immunoglobulins (TBII) and stimulating-blocking antibodies (TSBAb) in her serum. first infant died because septic shock fistula formation between the large intestine bladder. Serum hormone levels during pregnancy extremely low incomplete replacement therapy levothyroxine. second had almost normal...
We present the characterization of a case with small supernumerary marker chromosome (sSMC) detected prenatally derived from Xq28 and 14q11.2 maternal translocation. A 33-year-old Japanese woman, primigravida, underwent amniocentesis because fetal growth restriction structural abnormality at 30 weeks gestation. The karyotype was identified as 47,XY,+mar. Additionally, single nucleotide polymorphism array analysis revealed copy number gains 14q11.2. male infant, weighing 1,391 g, delivered...
"Welcome to OBGYN World!" A novel recruitment event for medical students organized by the Japan Society of Obstetrics and Gynecology. Since 2012, number doctors in who specialize obstetrics gynecology has shown a decreasing trend. To increase majoring gynecology, Japanese Trainees Gynecology subcommittee developed new called Welcome World! (WOW!); aim this was focus on lower grades students. The present report describes content WOW! results post-event questionnaire administered participating...
This study aimed to investigate the side effects of silicone gel sheet (Lady Care®) and evaluate its prophylactic efficacy in preventing abnormal scarring. Sixty women who underwent caesarean section were recruited from September 2016 2017 this prospective study. Lady Care® was applied 2nd 6th postoperative months. Side evaluated through medical examinations questionnaires. A plastic surgeon diagnosed Pruritus 25 (47.2%) patients; folliculitis, four (7.5%); dry skin, contact dermatitis,...
Small intestinal arteriovenous (AV) malformations may cause gastrointestinal hemorrhage, occasionally leading to anemia; however, they are rarely seen in pregnancy. This report presents a case of pregnant woman who had recurrent severe anemia that was attributed small hemorrhagic malformation.A 24-year-old (gravida 2, para 1) presented with low hemoglobin concentration (3.6 g/dL) her first pregnancy and underwent an emergency cesarean section at 36 weeks due non-reassuring fetal status. In...
Hypophosphatasia (HPP) is a congenital disease caused by deficiency of tissue-nonspecific alkaline phosphatase (TNALP) gene. The pathogenesis HPP varies, ranging from severe cases resulting in no fetal bone calcification to relatively mild cases. In recent years, the establishment enzyme supplementation as treatment method has prolonged survival patients. However, effects therapy on jawbone and periodontal tissues have not yet been studied detail. Therefore, this study, we investigated...
Abstract Aim To confirm that variations in cell‐free fetal DNA (cffDNA) are indicators of external placental damage, we quantitatively investigated cffDNA alterations maternal peripheral blood during cephalic version (ECV). Methods We recruited 48 singleton pregnant women who underwent ECV our hospital. Before and immediately after ECV, harvested 10 ml samples for analysis. were assessed based on the fraction (FF) rate. performed without epidural anesthesia but administered if was disrupted...