A5063921984- Neuroscience and Neuropharmacology Research
- Neurogenesis and neuroplasticity mechanisms
- Amino Acid Enzymes and Metabolism
- Pregnancy and preeclampsia studies
- Reproductive System and Pregnancy
- Anesthesia and Neurotoxicity Research
- Pharmaceutical Practices and Patient Outcomes
- Photoreceptor and optogenetics research
- Pharmacy and Medical Practices
- Toxoplasma gondii Research Studies
- Assisted Reproductive Technology and Twin Pregnancy
- Mitochondrial Function and Pathology
- Cardiac Ischemia and Reperfusion
- Anesthesia and Pain Management
- Caveolin-1 and cellular processes
- Cell Image Analysis Techniques
- Spinal Hematomas and Complications
- Prenatal Screening and Diagnostics
- Ion channel regulation and function
- Microtubule and mitosis dynamics
- Safe Handling of Antineoplastic Drugs
- Developmental Biology and Gene Regulation
- Glaucoma and retinal disorders
- Cardiac, Anesthesia and Surgical Outcomes
- Intraocular Surgery and Lenses
Tokyo Medical and Dental University
2015-2024
National Center For Child Health and Development
2014-2024
Institute of Science Tokyo
2024
Yamagata University
2017
Tokai University
1998-2015
Tokyo Medical and Dental University Hospital
2013
Tokyo Medical Center
2001
Johnson University
1990-1992
Keio University
1983-1985
Keio University Hospital
1980
To understand the possible functions and subcellular localizations of sulfonylurea receptors (SURs) in cardiac muscle, polyclonal anti-SUR2A anti-SUR2B antisera were raised. Immunoblots revealed both SUR2A SUR2B expression mitochondrial fractions rat heart other cellular such as microsomes cell membranes. Immunostaining detected ubiquitous atria, ventricles, interatrial interventricular septa, smooth muscles endothelia coronary arteries. Electron microscopy immunoreactivity membrane,...
Apotential complication of continuous epidural anesthesia is breakage and separation the catheter during its removal. We encountered a case an that occurred as it was extracted by using stainless steel hemostat, has been occasionally used to remove entrapped (1,2). This prompted us compare tensile strengths catheters different materials while they were being held with either hemostat or rubber sleeves. Case Report The patient 48-yr-old male without history back problems who underwent open...
The expression of human histocompatibility leukocyte antigen class II antigens on gastric epithelia and carcinoma (GaCa) was studied with the use murine monoclonal antibodies to DR, DQ, DP antigens. DR but not DQ were demonstrated in fundic glands normal epithelia, DP+ cells located part DR+ epithelia. Of 15 GaCas examined, 11 expressed antigen, degree varied considerably among specimens. found 3 carcinomas, one Thus appears be order DP, DQ. Studies GaCa cell lines (Kato III, MKN28, MKN45)...
We have introduced problem-based learning using small groups (five to 10 students per group) as a new teaching approach for pharmacy students. Our uses clinical cases and has four steps. First, the read problem identify any unfamiliar terminology. They then study these terms along with other issues requested by tutor. Second, in discussion period each student provides summary of his/her individual group an opportunity learn from members. The identifies what is understood works correct...
Abstract ATP sensitive K + (K ) channels are important linkage of cell membrane excitability to its cellular bioenergetic state. These composed pore‐forming subunits and regulatory subunits. The present study focused on the expressions localizations these in rat testis. RT‐PCR analysis showed that testis contained five channel subunits, Kir6.1, Kir6.2, SUR1, SUR2A SUR2B. Immunoblot assay proteins SUR2B were expressed Immunohistochemistry revealed positive different spermatogenic cells,...
Abstract HOX genes expressed in a specific spatial and temporal manner play crucial role determining the body plan during early development of vertebrates. In adult tissues, many participate normal hematopoiesis carcinogenesis. We previously found that overexpression homeobox gene HOXD3 alters expression levels cell adhesion molecules human cancer lines. Here, we have investigated whether is related to processes mouse focusing on dorsal midline cells or roof-plate neural tube crest cells....
mRNA vaccination is an effective, safe, and widespread strategy for protecting pregnant women against infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. However, information on factors such as perinatal outcomes, safety, coverage of vaccinations among limited in Japan. Therefore, this study aimed to investigate the coverage, adverse effects, short-term safety well vaccine hesitancy women.We conducted a multicenter online survey postpartum who delivered...
The aim of this study was to investigate the outcomes pregnancy in female childhood cancer survivors (CCS) Japan, encourage greater attention reproductive health CCS.This a retrospective nationwide questionnaire survey delivery at ≥22 weeks gestation CCS perinatal centers registered with Japanese Perinatologists Association between 2010 and 2014. We evaluated maternal characteristics, neonatal relationship treatment these outcomes.The total number 61, deliveries 71, corresponding 0.019%...
Abstract Aim This study examined the relationship between postpartum hair loss and psychological symptoms. Methods questionnaire‐based, cross‐sectional included women who had delivered at two facilities completed questionnaire 10–18 months after delivery. Study protocols were sent by mail in parts. Baseline characteristics information regarding pregnancy, delivery, childcare, obtained via a questionnaire. Psychological symptoms assessed Whooley Questions, Generalized Anxiety Disorder 2‐item,...
Limited data have been reported on the use of proprotein convertase subtilisin/kexin type 9 (PCSK 9) inhibitors during pregnancy in women with familial hypercholesterolemia (FH). Here, we present first case initiating evolocumab (PCSK9 inhibitor) a compound heterozygous FH mother. The patient was 34-year-old primipara severe dyslipidemia and history coronary artery bypass surgery. An elevated low-density lipoprotein cholesterol (LDL-C) level 420 mg/dL detected trimester persistently...
We have introduced improvements and new approaches into our teaching methods by exploiting 4 active learning for pharmacy students of first year. The each lesson or take home assignment are follows: 1) problem-based (clinical case) including a student presentation the clinical case, 2) schematic drawings human organs, one drawing done in 15—20 min during week following lecture second with reference to professional textbook, 3) themes assignments, 4) short test order confirm understanding...
The dreher mutation (gene symbol: dr) is an autosomal recessive located on chromosome 1 of the mouse. Homozygous mice (dr/dr) are ataxic, have a white belly spot, short-tail, inner ear and skeletal malformations, variety CNS abnormalities. Recently in our colony (the drsst-J allele B6C3Fe background), we noticed with one or more spots tyical /drsst-Jmice but which were non-ataxic had normal tail length; wild-type (+ / +) same genetic background do not simialr spots. Results three breeding...
Calyceal diverticula are congenital, nonsecretory abnormalities in which the transitional cell-lined cavity communicates with renal collecting system. Here we present case of a calyceal diverticular abscess during pregnancy. A 40-year-old primiparous woman developed at 23 weeks gestation, right flank pain and 37.8°C fever. transabdominal ultrasound revealed 12 × 10 cm cystic mass kidney. She was initially diagnosed simple cyst infection, intravenous antibiotics were initiated. Percutaneous...
A rare variation was found in one of the two left renal veins a 94-year-old male cadaver undergoing routine dissection. The characteristic findings included, addition to primary vein, presence posterior vein draining ascending lumbar without communicating with inferior vena cava and other veins. Variations number arrangement vessels terminating are common, but our knowledge, similar has not been previously reported. This may represent an immature form complicated development vessels.