A5102924980- Heart Failure Treatment and Management
- Cardiovascular Function and Risk Factors
- Cardiac Imaging and Diagnostics
- Acute Myocardial Infarction Research
- Nutrition and Health in Aging
- Cardiac Arrest and Resuscitation
- Pulmonary Hypertension Research and Treatments
- Cardiac Fibrosis and Remodeling
- Renal function and acid-base balance
- Cardiac electrophysiology and arrhythmias
- Cardiomyopathy and Myosin Studies
- Acute Kidney Injury Research
- Viral Infections and Immunology Research
- Potassium and Related Disorders
- Cardiovascular Disease and Adiposity
- Cardiac pacing and defibrillation studies
- Cardiac Ischemia and Reperfusion
- Venous Thromboembolism Diagnosis and Management
- Intensive Care Unit Cognitive Disorders
- Cardiac, Anesthesia and Surgical Outcomes
- Aortic Disease and Treatment Approaches
- Aortic aneurysm repair treatments
- Cardiovascular and exercise physiology
- Liver Disease and Transplantation
- Infectious Aortic and Vascular Conditions
Hokkaido University
2017-2024
National Cerebral and Cardiovascular Center
1995-2021
Imperial College London
2017-2021
Nippon Medical School
2021
Lung Institute
2018-2019
Kitasato University
2001-2018
Keio University
2010-2012
National Hospital Organization Saitama Hospital
2012
National Hospital Organization
2012
Despite the specific characteristics of heart failure with preserved ejection fraction (HFpEF) having been demonstrated predominantly from registries in Western countries, important international differences exist terms patient characteristics, management and medical infrastructure between Asian countries.
Abstract Aims Predictive models for heart failure patients are widely used in the clinical practice to stratify patients' mortality and enable clinicians tailor intensify their approach. However, such have not been validated internationally. In addition, biomarkers now frequently measured obtain prognostic information, implications of this known. study, we aimed validate model performance Meta‐analysis Global Group Chronic Heart Failure (MAGGIC) score a Japanese acute registry further...
Increased angiogenesis, chronic inflammation, and extracellular matrix degradation are the major pathological features of abdominal aortic aneurysm (AAA). We sought to elucidate role vascular endothelial growth factor (VEGF)-A, a potent angiogenic proinflammatory factor, in development AAA. Human AAA samples showed increased VEGF-A expression, neovascularization, macrophage infiltration compared with normal walls. was induced mice by periaortic application CaCl2. were treated soluble...
C-reactive protein (CRP) is known to be a pathogenic agent in the cardiovascular system. However, effect of CRP on heart failure has not been elucidated. The human cardiac dysfunction induced by diabetes mellitus (DM) using CRP-overexpressing transgenic mice (CRP-Tg) was examined.DM male wild-type (Wt/DM) and CRP-Tg (CRP/DM) an injection streptozotocin. Non-diabetic (Wt/Con) (CRP/Con) served as controls. Echocardiography hemodynamic measurements 6 weeks after showed lower fractional...
There are limited studies regarding the prognostic value of coagulation abnormalities in heart failure patients. The clinical significance prothrombin time international normalized ratio (INR), a widely accepted marker assessing abnormalities, acute decompensated (ADHF) remains unclear.Among 561 consecutive patients admitted for ADHF, INR was assessed 294 without prior anticoagulation therapy, coronary syndrome, liver disease, or overt disseminated intravascular coagulation. Increased on...
We hypothesized that exhaled acetone concentration (EAC), reflecting altered blood ketone body metabolism and increased exhaust because of pulmonary congestion in heart failure (HF), would correlate with hemodynamic parameters patients non-ischemic chronic HF.We prospectively enrolled 102 HF New York Heart Association (NYHA) class I-III. Exhaled breath was collected after an overnight fast. Echocardiography cardiac catheterization were performed all patients. also 17 control without HF. EAC...
▋ 3.3.1 Acute HF a. Organized Program to Initiate Lifesaving Treatment in Hospitalized Patients With Heart Failure (OPTIMIZE-HF) Risk Score OPTIMIZE-HF 56 is a model derived from large real-world registry that enrolled approximately 50,000 patients with acute the USA.Risk scores are calculated using 7 factors: age, systolic blood pressure, heart rate, serum creatinine, sodium, cause of hospitalization, and left ventricular ejection fraction (LVEF). b. Get The Guidelines-HF (GWTG-HF)...
We previously reported serum C-reactive protein (CRP) elevation after acute myocardial infarction (MI) to be associated with adverse outcomes including cardiac rupture, left ventricular (LV) remodeling, and death. Experimental studies have indicated that CRP per se has various biological actions proinflammatory proapoptotic effects, suggesting a pathogenic role of in the post-MI remodeling process. tested hypothesis increased expression would exacerbate LV MI via deleterious effects CRP....
Abstract Aims The prognostic implication of left ventricular outflow tract velocity time integral (LVOT‐VTI) on admission in hospitalized heart failure with preserved ejection fraction (HFpEF) patients has not been determined. We sought to investigate whether LVOT‐VTI is associated worse clinical outcomes HFpEF. Methods and results studied consecutive 214 HFpEF who had accessible data admission, from a prospective HFpEF‐specific multicentre registry. primary outcome interest was the...
The association between prolonged delirium during hospitalization and long-term prognosis in patients with acute heart failure (AHF) admitted to the cardiac intensive care unit (CICU) has not been fully elucidated.
Myocarditis is a heterogeneous disease with diverse etiologies and clinical trajectories. Traditionally, its diagnosis has been guided by the Dallas criteria, which focus on histopathological features. Clinically, myocarditis categorized as acute or chronic based duration since symptom onset. However, recent expert consensus, particularly in Western countries, redefined either inflammatory cardiomyopathy, including dilated reflecting advancements viral genome analysis histopathology. In...