A5083356005- Pancreatic function and diabetes
- Diabetes and associated disorders
- Diabetes Management and Research
- Diabetes Treatment and Management
- Metabolism, Diabetes, and Cancer
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Adipokines, Inflammation, and Metabolic Diseases
- COVID-19 Clinical Research Studies
- Pancreatic and Hepatic Oncology Research
- Neuroendocrine Tumor Research Advances
- Pancreatitis Pathology and Treatment
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Diet and metabolism studies
- Long-Term Effects of COVID-19
- SARS-CoV-2 and COVID-19 Research
- Diabetes Management and Education
- Adipose Tissue and Metabolism
- Parkinson's Disease Mechanisms and Treatments
- Dermatological and COVID-19 studies
- Liver Disease Diagnosis and Treatment
- Genetic Syndromes and Imprinting
- Regulation of Appetite and Obesity
- Sepsis Diagnosis and Treatment
- Apelin-related biomedical research
- Genetic Neurodegenerative Diseases
Toyonaka Municipal Hospital
2000-2024
Osaka University
2013-2022
Weatherford College
2021
Diabetes Australia
2021
Suzuki (Japan)
2021
Suita Municipal Hospital
2012
Yamamoto Hospital
2003
Itochu (Japan)
2000
Otsuka (Japan)
2000
Shizuoka Red Cross Hospital
1997-1998
Abstract —Adiponectin is a novel, adipose-specific protein abundantly present in the circulation, and it has antiatherogenic properties. We analyzed plasma adiponectin concentrations age- body mass index (BMI)–matched nondiabetic type 2 diabetic subjects with without coronary artery disease (CAD). Plasma levels of CAD were lower than those (6.6±0.4 versus 7.9±0.5 μg/mL men, 7.6±0.7 11.7±1.0 women; P <0.001). The patients (4.0±0.4 6.6±0.4 μg/mL, <0.001 men; 6.3±0.8 women). In contrast,...
Abstract Neurofilament light chain (NfL) is a novel biomarker of neurodegenerative diseases. It detectable in the peripheral blood, allowing low-invasive assessment early signs neurodegeneration. The level NfL gradually increases with age; however, what other factors affect it remains unclear. present study examined association between blood and renal function among healthy participants undergoing health check (n = 43, serum NfL) patients diabetes mellitus 188, plasma NfL). All were 60 years...
Insulin-dependent diabetes mellitus (IDDM) is assumed to be a T cell–mediated autoimmune disease. To investigate the role of Fas-mediated cytotoxicity in pancreatic β cell destruction, we established nonobese diabetic (NOD)-lymphoproliferation (lpr)/lpr mice lacking Fas. Out three genotypes, female NOD-+/+ and NOD-+/lpr developed spontaneous by age 10 mo with incidence 68 62%, respectively. In contrast, NOD-lpr/lpr did not develop or insulitis. further explore Fas, adoptive transfer...
Cellular oxygen consumption is a determinant of intracellular levels. Because the high demand mitochondrial respiration during insulin secretion, pancreatic β-cells consume large amounts in short time period. We examined effect secretion on cellular tension vitro. confirmed that Western blotting pimonidazole adduct was more sensitive than immunostaining for detection hypoxia vitro and vivo. The islets diabetic mice but not those normal were hypoxic, especially when dose glucose loaded. In...
A decrease in pancreatic β-cell mass is involved the development of type 2 diabetes.The purpose this study was to evaluate and incidence neogenesis, replication, apoptosis at both prediabetic diabetic stages.We conducted a cross-sectional tissues obtained from 42 patients undergoing pancreatectomy who were classified into 4 groups: normal glucose tolerance (n = 11), impaired newly diagnosed diabetes 10), long-standing 10).The relative area decreased increased during diabetes. The number...
One subtype of maturity-onset diabetes the young (MODY)-3 results from mutations in gene encoding hepatocyte nuclear factor (HNF)-1α. We generated transgenic mice expressing a naturally occurring dominant-negative form human HNF-1α (P291fsinsC) pancreatic β-cells. A progressive hyperglycemia with age was seen these mice, and developed impaired glucose-stimulated insulin secretion. The islets exhibited abnormal architecture reduced expression glucose transporter (GLUT2) E-cadherin. Blockade...
To better understand the pathogenesis of type 1 diabetes, we have developed pancreatic biopsy under laparoscope for recent-onset diabetic patients. The patients included 29 acute-onset patients, 5 latent-onset and 2 patient. Their median age was 28 years, duration diabetes at time ∼3 months. In 31 35 could obtain pancreas tissue by punching. No serious complications, such as heavy bleeding, peritonitis, or pancreatitis, been experienced. Pneumoderma observed in two abdominal dull pain had...
Visceral fat accumulation is associated with the development of metabolic disorders such as glucose intolerance, dyslipidemia, hypertension, and atherosclerotic cardiovascular diseases (1–8). However, relationship between reduction visceral decrease in number risk factors has not been defined general population. Recently, we developed a new technique, abdominal bioelectrical impedance analysis (BIA), to evaluate area (VFA) (9). The aim this study was investigate whether fat, estimated by...
Objective Visceral fat accumulation is an underlying component of the metabolic syndrome (MetS). Hypoadiponectinemia one key molecules MetS. In present study, we investigated relationship between serum uric acid level, visceral and adiponectin concentration in Japanese men. Patients Methods The study group comprised 1,520 employed men (mean age: 45.6±10.4 years, ± SD), who had undergone annual health check-up both 2004 2005. addition to parameters measured check-up, area (VFA) were by...
Homeostasis model assessment of insulin resistance (HOMA-IR) is a simple and useful method for evaluating sensitivity. But it difficult to apply type2 diabetes patients treated with insulin. We have devised measuring HOMA-IR investigated the validity sensitivity in type 2 on therapy. In first arm study, 19 poorly controlled diabetic subjects were underwent euglycemic clamp study. Then relationship between index assessed by test (clamp-IR) was these subjects. Log transformed correlated log...
The type 3 form of maturity-onset diabetes the young (M0DY3) results from mutations in gene encoding transcription factor, hepatocyte nuclear factor-1α (HNF-1α). mechanism by which only one allele HNF-1α impair pancreatic β-cell function is unclear. functional a dimer—either homodimer or heterodimer with structurally related protein HNF-1β—that binds to and activates genes whose expression it regulates. composed three domains: an amino-terminal dimerization domain (amino acids 1–32),...
The objective of this study was to characterize the clinical and immunogenetic features Japanese pregnancy-associated fulminant type 1 diabetes (PF). A group patients with PF compared a child-bearing age that not associated pregnancy (NPF) in nationwide survey conducted from 2000-2004.The characteristics 22 were those 48 NPF group. Human leukocyte antigen (HLA) class II DR DQ genotyping 17 20 performed.Arterial pH significantly lower (P = 0.0366), amylase values tended increase 0.0515). In...
The aim of this study is to present direct evidence for the involvement CXC chemokine ligand 10 (CXCL10) and CXCR3 in human autoimmune type 1 diabetes. We examined five patients with recent-onset diabetes control subjects without Islet cell antibodies or GAD both were detected all patients. used double-immunofluorescence detect expression CXCL10 (the receptor CXCL10). was islets Almost (84.2 ± 10.3 %, mean SD) CXCL10-positive cells insulin-positive islet area. glucagons, somatostatins...
Abstract Context: Fulminant type 1 diabetes mellitus (T1DM) is thought to be partly caused by virus infection. Objective: This study investigated the mechanism of β cell destruction in fulminant T1DM after drug-induced hypersensitivity syndrome (DIHS). Methods: We determined localization human cytomegalovirus (HCMV), herpesvirus 6 (HHV-6), and Epstein-Barr (EBV) expression interferon regulatory factor 3 (IRF3) viral receptors Z-DNA binding protein (ZBP1) retinoic acid-inducible gene I...
Aims/Introduction: Recently, glucagon-like peptide-1 (GLP-1) receptor agonists of liraglutide have become available in Japan. It has not yet been clarified what clinical parameters could discriminate liraglutide-effective patients from liraglutide-ineffective patients. We reviewed 23 consecutive with type 2 diabetes admitted to Osaka University Hospital for glycemic control. All the were treated diet plus insulin (or oral antidiabetic drugs) improve fasting plasma glucose (FPG) and...