A5067446953- Dementia and Cognitive Impairment Research
- Alzheimer's disease research and treatments
- Parkinson's Disease Mechanisms and Treatments
- Functional Brain Connectivity Studies
- Neurobiology of Language and Bilingualism
- Schizophrenia research and treatment
- Amyotrophic Lateral Sclerosis Research
- Structural Load-Bearing Analysis
- Railway Engineering and Dynamics
- Structural Behavior of Reinforced Concrete
- Neurological Disease Mechanisms and Treatments
- EEG and Brain-Computer Interfaces
- Health disparities and outcomes
- RNA Research and Splicing
- Geriatric Care and Nursing Homes
- Sleep and related disorders
- Structural Engineering and Vibration Analysis
- Neurogenetic and Muscular Disorders Research
- Memory and Neural Mechanisms
- Neurological disorders and treatments
- Cerebrospinal fluid and hydrocephalus
- Stroke Rehabilitation and Recovery
- T-cell and Retrovirus Studies
- Neurological Disorders and Treatments
- Traumatic Brain Injury and Neurovascular Disturbances
Osaka University
2016-2025
Nippon Medical School Hospital
2019-2024
San Francisco VA Medical Center
2024
University of California, San Francisco
2024
Kumamoto University Hospital
2011-2023
Kumamoto University
2011-2022
Osaka University Hospital
2021-2022
Shin Nippon Biomedical Laboratories (Japan)
2022
Mayo Clinic in Florida
2020
Mayo Clinic
2020
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Despite numerous reports of changes in satiety, food preference, and eating habits patients with frontotemporal dementia, there have been few systematic studies.To investigate the frequency behaviours sequence development dementia Alzheimer's disease, using a caregiver questionnaire.Three groups were studied: frontal variant (fv-FTD) (n = 23), semantic 25), disease 43). Level education severity was similar three groups. The questionnaire consisted 36 questions investigating five domains:...
Because cholinergic deficits are prominent in dementia with Lewy bodies (DLB), we investigated the effects of a cholinesterase inhibitor, donepezil, such patients randomized, double-blind, placebo-controlled exploratory phase 2 trial.One-hundred forty DLB, recruited from 48 specialty centers Japan, were randomly assigned to receive placebo or 3, 5, 10 mg donepezil hydrochloride daily for 12 weeks (n = 35, 33, and 37, respectively). Effects on cognitive function assessed using Mini-Mental...
Abstract Neurofilament light chain (NfL) is a novel biomarker of neurodegenerative diseases. It detectable in the peripheral blood, allowing low-invasive assessment early signs neurodegeneration. The level NfL gradually increases with age; however, what other factors affect it remains unclear. present study examined association between blood and renal function among healthy participants undergoing health check (n = 43, serum NfL) patients diabetes mellitus 188, plasma NfL). All were 60 years...
Despite many studies about the association between caregiver burden and behavioral psychological symptoms of dementia (BPSD), there have been no population-based to evaluate associated with each BPSD.To individual BPSD in elderly people living community.The subjects were 67 participants their caregivers (diagnosed third Nakayama study): 51 Alzheimer's disease, 5 vascular 11 other. The Neuropsychiatric Inventory (NPI) NPI Caregiver Distress Scale (NPI-D) used assess subjects' related...
Background Eating is one of the most important daily activities in managing patients with dementia. Although various eating disturbance occur as dementia progresses, to our knowledge, studies focused on a part such swallowing and appetite. There have been few comprehensive including habits food preference Alzheimer’s disease (AD). The aims this study were investigate almost all examine relationship stage AD. Methods A total 220 AD 30 normal elderly (NE) subjects recruited. was assessed by...
Behavioral and psychological symptoms of dementia (BPSDs) negatively impact the prognosis patients increase caregiver distress. The aims this study were to clarify differences trajectories 12 kinds BPSDs by disease severity in four major dementias develop charts showing frequency, severity, associated distress (ACD) using data a Japan multicenter (J-BIRD).We gathered Neuropsychiatric Inventory (NPI) with Alzheimer's (AD; n = 1091), Lewy bodies (DLB; 249), vascular (VaD; 156), frontotemporal...
This paper proposes a new approach to automatically detect dementia. Even though some works have detected dementia from speech and language attributes, most applied detection using picture descriptions, narratives, cognitive tasks. In this paper, we propose computer avatar with spoken dialog functionalities that produces queries based on the mini-mental state examination, Wechsler memory scale-revised, other related neuropsychological questions. We recorded interactive data of dialogues 29...
Abstract Background The burden of dementia is growing rapidly and has become a medical social problem in Japan. Prospective cohort studies have been considered an effective methodology to clarify the risk factors etiology dementia. We aimed perform large-scale study elucidate environmental genetic for dementia, as well their interaction. Methods Japan Studies Collaboration Aging Dementia (JPSC-AD) multisite, population-based prospective which was designed enroll approximately 10,000...
This study investigated the association between green tea or coffee consumption with cerebral white matter lesions and hippocampal total brain volumes among 8766 community-dwelling participants recruited from Japan Prospective Studies Collaboration for Aging Dementia 2016 2018. A Food Frequency Questionnaire was used to assess consumption, whereas magnetic resonance imaging performed lesions, volume, volume. Multivariable-adjusted analysis revealed significant correlations fewer higher no...
Aim Despite the clinical importance and significant social burden of neuropsychiatric symptoms (NPS) in dementia, underlying neurobiological mechanism remains poorly understood. Recently, neuroimaging‐derived brain‐age estimation by machine‐learning analysis has shown promise as an individual‐level biomarker. We investigated relationship between NPS amnestic mild cognitive impairment (MCI) early dementia. Methods In this cross‐sectional study, data, including inventory (NPI), structural...
It has been suggested that there is a major difference in the ratio of AD to vascular dementia (VaD) between Japan and Western countries. To determine type-specific prevalence community-dwelling elderly from Japanese community Nakayama, all patients with dementing illness underwent CT scan.A door-to-door three-phase population survey was carried out on persons aged 65 years older residing at home day (January 1, 1997). The ascertainment cases made January 1997 March 1998. study included...
<h3>OBJECTIVES</h3> Memory impairment is not only the earliest clinical symptom but a central and prominent feature throughout course of Alzheimer's disease. Alzheimer related pathological alterations in medial temporal structures may account for memory impairments patients with The aim this study was to elucidate role caused by <h3>METHODS</h3> Using high resolution MRI semiautomated image analysis technique, volumes (amygdaloid complex, hippocampal formation, subiculum, parahippocampal...
Abstract Objective To compare family caregiving situations for patients with early onset dementia (EOD) and late (LOD), to identify the specific problems experienced by relatives caring EOD patients. Methods The participants were chosen from 92 consecutive caregiver–patient dyads, comprising co‐residing caregivers outpatients who fulfilled diagnostic criteria dementia. assessed according cognitive function, neuropsychiatric disturbances severity of completed a self‐administered questionnaire...
Abstract Aim: This study aimed to investigate factors associated with depression in a sample of elderly Japanese individuals rural community and examine differences among living alone or others. Methods: Using population‐based from Japan, we assessed total 1552 participants aged 65 years older by mailing survey evaluating responses based on the Geriatric Depression Scale. Factors were also examined. Results: We received 964 valid responses. Depressed subjects comprised 20.5% sample. Living...
Abstract Introduction The efficacy of a cholinesterase inhibitor, donepezil, in patients with dementia Lewy bodies (DLB) was investigated to confirm the superiority over placebo 12-week, double-blind phase this III study. Methods Patients probable DLB ( n = 142) were randomly assigned or 5 mg 10 donepezil administered once daily for 12 weeks. co–primary endpoints changes cognitive function assessed using Mini-Mental State Examination (MMSE) and behavioral neuropsychiatric symptoms...
Background Visual hallucinations are a core clinical feature of dementia with Lewy bodies (DLB), and this symptom is important in the differential diagnosis prediction treatment response. The pareidolia test tool that evokes visual hallucination-like illusions, these illusions may be surrogate marker DLB. We created simplified version examined its validity reliability to establish utility test. Methods was administered 52 patients DLB, Alzheimer's disease (AD) 20 healthy controls (HCs)....
Abstract Background The features of behavioural and psychological symptoms dementia ( BPSD ) are influenced by stage. In early‐onset A lzheimer's disease EOAD ), the association between stage remains unclear because difficulty recruiting subjects with a wide range severity. We used combination community‐based hospital‐based approaches to investigate relationship severity in patients. Methods Sixty‐three consecutive outpatients 29 patients from survey were divided into three groups according...
Abstract Alzheimer’s disease (AD) is a progressive neuropsychiatric affecting many elderly people and characterized by cognitive impairment of memory, visuospatial, executive functions. As the population growing, number AD patients increasing considerably. There currently growing interest in determining AD’s dysfunction markers. We used exact low-resolution-brain-electromagnetic-tomography independent-component-analysis (eLORETA-ICA) to assess activities five electroencephalography...
Abstract In recent years, the association between neuroinflammatory markers and dementia, especially Alzheimer’s disease (AD), has attracted much attention. However, evidence for relationship serum-hs-CRP dementia including AD are inconsistent. Therefore, relationships of serum high-sensitivity CRP (hs-CRP) with regions interest brain MRI were investigated. A total 11,957 community residents aged 65 years or older recruited in eight sites Japan (JPSC-AD Study). After applying exclusion...