A5024861785- Dementia and Cognitive Impairment Research
- Functional Brain Connectivity Studies
- Cerebrospinal fluid and hydrocephalus
- EEG and Brain-Computer Interfaces
- Traumatic Brain Injury and Neurovascular Disturbances
- Wireless Communication Networks Research
- Neurosurgical Procedures and Complications
- Power Line Communications and Noise
- Schizophrenia research and treatment
- Geriatric Care and Nursing Homes
- Neural dynamics and brain function
- Alzheimer's disease research and treatments
- Mental Health and Psychiatry
- Fetal and Pediatric Neurological Disorders
- Neurological Disease Mechanisms and Treatments
- Sleep and related disorders
- Scoliosis diagnosis and treatment
- Telecommunications and Broadcasting Technologies
- COVID-19 and Mental Health
- Memory and Neural Mechanisms
- Parkinson's Disease Mechanisms and Treatments
- Brain Tumor Detection and Classification
- Advanced Adaptive Filtering Techniques
- Advanced MIMO Systems Optimization
- Health and Wellbeing Research
Osaka University
2016-2025
Osaka Health Science University
2024-2025
Counseling Center
2024
Osaka Kawasaki Rehabilitation University
2018-2021
Panasonic (Japan)
2017-2021
Wakayama Medical University
2020
Kansai University of Welfare Sciences
2020
Takeda (Japan)
2020
Among the various disorders that manifest with gait disturbance, cognitive impairment, and urinary incontinence in elderly population, idiopathic normal pressure hydrocephalus (iNPH) is becoming of great importance. The first edition these guidelines for management iNPH was published 2004, second 2012, to provide a series timely, evidence-based recommendations related iNPH. Since last edition, clinical awareness has risen dramatically, basic research efforts on have increased significantly....
To explore neurophysiological biomarkers of Alzheimer's disease (AD), we investigated electroencephalography (EEG) AD patients, and assessed lagged phase synchronization, a measure brain functional connectivity. Twenty-eight probable patients 30 healthy controls (HC) were enrolled. Forty seconds artifact-free EEG data selected compared between with HC. Current source density (CSD) synchronization analyzed by using eLORETA. Patients showed significantly decreased most cortical regions in...
Behavioral and psychological symptoms of dementia (BPSDs) negatively impact the prognosis patients increase caregiver distress. The aims this study were to clarify differences trajectories 12 kinds BPSDs by disease severity in four major dementias develop charts showing frequency, severity, associated distress (ACD) using data a Japan multicenter (J-BIRD).We gathered Neuropsychiatric Inventory (NPI) with Alzheimer's (AD; n = 1091), Lewy bodies (DLB; 249), vascular (VaD; 156), frontotemporal...
Abstract Background This study aimed to identify cases of potential prodromal DLB in very late-onset schizophrenia-like psychosis (VLOSLP), using indicative biomarkers dementia with Lewy bodies (DLB), and evaluate the characteristics as DLB. Methods Data patients VLOSLP without Parkinsonism, who underwent testing for at least one biomarker DLB, were retrospectively collected from database psychiatry clinic Osaka University Hospital. Patients divided into two groups based on positive...
Background The current biomarker-supported diagnosis of Alzheimer’s disease (AD) is hindered by invasiveness and cost issues. This study aimed to address these challenges utilizing portable electroencephalography (EEG). We propose a novel, non-invasive, cost-effective method for identifying AD, using sample patients with biomarker-verified facilitate early accessible screening. Methods included 35 confirmed via cerebrospinal fluid sampling, age- sex-balanced healthy volunteers (HVs). All...
Mild cognitive impairment (MCI) is a transitional state between normal ageing and dementia in cognition daily function. Patients with MCI initially exhibit subtle decline efficiency and/or accuracy performing activities of living (ADL), particularly those requiring complex functions, such as financial management food preparation.1, 2 These activities, referred to instrumental ADL (IADL), are affected prior basic (BADL) dressing bathing. Alzheimer's disease (AD) (ADD) demonstrate both BADL...
Diagnosing Alzheimer's disease (AD) through pathological markers is typically costly and invasive. This study aims to find a noninvasive, cost-effective method using portable electroencephalography (EEG) detect changes in AD-related biomarkers cerebrospinal fluid (CSF). A total of 102 patients, both with without biomarker (amyloid beta phosphorylated tau), were recorded 2-minute resting-state EEG. machine-learning algorithm then analyzed the EEG data identify these changes. The results...
Aim Despite the clinical importance and significant social burden of neuropsychiatric symptoms (NPS) in dementia, underlying neurobiological mechanism remains poorly understood. Recently, neuroimaging‐derived brain‐age estimation by machine‐learning analysis has shown promise as an individual‐level biomarker. We investigated relationship between NPS amnestic mild cognitive impairment (MCI) early dementia. Methods In this cross‐sectional study, data, including inventory (NPI), structural...
There has been no systematic analysis of coping strategies for behavioral and psychological symptoms dementia (BPSD) using large-scale cumulative data. We preliminarily examined the characteristics successful unsuccessful BPSD. employed a deductive inductive (hybrid approach) data derived from "Ninchisho Chienowa-net," web-based system that collects caregivers' Antecedent control procedure consequence manipulation in applied behavior (ABA) were used as theory-driven codes classification....
This study identifies neuropsychiatric syndromes and investigates their relationship with neuroimaging in Alzheimer's disease dementia (AD), Lewy bodies (DLB), mild cognitive impairment (MCI). Magnetic resonance imaging perfusion single-photon emission computed tomography data were collected for 281, 68, 180 patients AD, DLB, MCI, respectively, from three Japanese institutions. Neuropsychiatric Inventory was used exploratory factor analysis each group. Statistical Parametric Mapping...
<title>Abstract</title> <bold>Background:</bold> Hypersensitivity to antipsychotic drugs is one of the supportive features dementia with Lewy bodies, and side effects other than antipsychotics are also known occur frequently. We experienced a case bodies in which hallucinations delusions repeatedly appeared disappeared after administration discontinuation mirogabalin pregabalin. <bold>Case presentation: </bold>The patient, woman her late 70s, developed delusional misidentification places...
Background and Objective: Dementia with Lewy bodies (DLB) is frequently misdiagnosed as Alzheimer's disease (AD) due to overlapping clinical presentations. In this study, we evaluated a smartphone-based digital platform that leverages behavioral markers accurately differentiate between DLB AD. Methods: We conducted cross-sectional study on 81 participants (Healthy controls = 40, AD 21, 20), administering MMSE, noise pareidolia test (NPT) integrated eye-tracking speech inputs. Ground truth...
Background Sleep disturbances in Alzheimer disease (AD) may affect behavioral and psychological symptoms of dementia (BPSD). Our aim was to elucidate the associations between sleep other BPSD at different stages AD. Methods This investigation part a multicenter‐retrospective study Japan (J‐BIRD). Eligible for final analyses were 684 AD patients. Global severity estimated using Clinical Dementia Rating (CDR) scale. assessed Neuropsychiatric Inventory (NPI). We analyzed relationships according...
An abstract is not available for this content. As you have access to content, full HTML content provided on page. A PDF of also in through the 'Save PDF' action button.
Robotic assistive technology for frail older adults has drawn attention, along with raising ethical concerns. The implications of a robot's usage have been characterized in the literature as detrimental, such emotional deception, unhealthy attachment, and reduced human contact from deontological perspective. These concerns require practical investigations, although long-term effect robot on remains uncertain. Our longitudinal study aimed to investigate how cognitive decline could be affected...
ABSTRACT Objectives: We aimed to investigate the association between very late-onset schizophrenia-like psychosis (VLOSLP), a schizophrenia spectrum disorder with an onset of ≥60 years, and Alzheimer’s disease (AD) using biomarkers. Design: Retrospective cross-sectional study. Setting: Neuropsychology clinic Osaka University Hospital in Japan. Participants: Thirty-three participants were classified into three groups: eight AD biomarker-negative VLOSLP (VLOSLP−AD), nine biomarker-positive...
Objectives:We aimed to psychometrically evaluate and validate a Japanese version of the Social Functioning in Dementia scale (SF-DEM-J) investigate changes social function people with dementia during coronavirus disease-19 (COVID-19) pandemic.Design:We interviewed mild cognitive impairment (MCI) their caregivers June 2020–March 2021 patient- caregiver-rated SF-DEM-J compared scores at baseline (April 2020 May 2020) 6–8 months (January March 2021) time tighter COVID-19...
Dementia with Lewy bodies (DLB) is characterized by progressive cognitive decline, fluctuating cognition, visual hallucinations, rapid eye movement sleep behavior disorder, and parkinsonism. DLB the second most common type of degenerative dementia all cases. However, DLB, particularly in early stage, underdiagnosed sometimes misdiagnosed other types dementia. Thus, it great interest investigating neurophysiological markers DLB.We introduced exact low-resolution brain electromagnetic...
It is critical to develop accurate and universally available biomarkers for dementia diseases appropriately deal with the problems under world-wide rapid increasing of patients dementia. In this sense, electroencephalography (EEG) has been utilized as a promising examination screen assist in diagnosing dementia, advantages sensitiveness neural functions, inexpensiveness, high availability. Moreover, algorithm-based deep learning can expand EEG applicability, yielding automatic classification...
Background: Although apathy is associated with damage to the frontal and temporal lobes in Alzheimer's disease (AD), crucial regions for patients amnestic mild cognitive impairment (aMCI) are unknown. Objective: To identify brain aMCI patients. M ethods: The subjects of this study were 98 who entered our dementia registry between March 1, 2009 April 30, 2015 satisfied criteria aMCI. association score Neuropsychiatric Inventory regional gray matter volume was analyzed using voxel-based...
Visual hallucinations (VH) are associated with visual prediction error in patients dementia Lewy bodies (DLB). Given this relationship, environmental adjustments have been suggested, but detailed contents for implementing such and assessments poorly documented. This case report preliminarily demonstrates methods improving VH through our experience two DLB. We conducted familial interviews to assess the phenomenological features of reviewed photographs patients' homes identify triggers VH,...
Late-onset psychosis refers to the development of psychotic symptoms after age 40 and can encompass various conditions like schizophrenia, mood disorders with features, delusional disorder. Non-pharmacological interventions are critically important in older adults psychosis, especially considering lack evidence for efficacy antipsychotics high risk side effects. Social isolation is recognized as one risks late-onset eliminate this becoming increasingly Japan, where social among people...