A5102727382- Cerebrospinal fluid and hydrocephalus
- Spinal Dysraphism and Malformations
- Fetal and Pediatric Neurological Disorders
- Neurosurgical Procedures and Complications
- Traumatic Brain Injury and Neurovascular Disturbances
- Pituitary Gland Disorders and Treatments
- Acute Ischemic Stroke Management
- Glioma Diagnosis and Treatment
- Spinal Fractures and Fixation Techniques
- Head and Neck Surgical Oncology
- Meningioma and schwannoma management
- Genetic and Kidney Cyst Diseases
- Venous Thromboembolism Diagnosis and Management
- Neonatal Respiratory Health Research
- Cardiac Imaging and Diagnostics
- Pediatric Urology and Nephrology Studies
- Brain Metastases and Treatment
- Asthma and respiratory diseases
- Testicular diseases and treatments
- Vascular Malformations Diagnosis and Treatment
- Protease and Inhibitor Mechanisms
- Cerebrovascular and Carotid Artery Diseases
- Nitric Oxide and Endothelin Effects
- Electrolyte and hormonal disorders
- Cardiovascular Syncope and Autonomic Disorders
Noto General Hospital
2015-2024
Japanese Red Cross Kochi Hospital
2024
Yokohama Sakae Kyosai Hospital
2017-2019
Kanazawa University Hospital
2009-2016
Kanazawa University
2008-2015
Centre International de Recherche sur le Cancer
2009
Harvard University Press
1995
Among the various disorders that manifest with gait disturbance, cognitive impairment, and urinary incontinence in elderly population, idiopathic normal pressure hydrocephalus (iNPH) is becoming of great importance. The first edition these guidelines for management iNPH was published 2004, second 2012, to provide a series timely, evidence-based recommendations related iNPH. Since last edition, clinical awareness has risen dramatically, basic research efforts on have increased significantly....
Nitric oxide (NO) is known to be present in measurable quantities the exhaled air of normal subjects and at higher concentrations asthmatic not treated with glucocorticoids. We confirmed these findings by analyzing mean mixed expired NO 43 stable asthmatics 90 subjects; levels were population (13.9 parts per billion [ppb] versus 6.2 ppb, p < 0.001). Although effects glucocorticoids on content are known, it if beginning systemic glucocorticoid therapy reduces a given individual. To examine...
We evaluated 715 glioblastoma patients diagnosed during 1980-1994 in the Canton of Zurich, Switzerland, to provide information on how were treated at population level. Despite a general policy study period treatment by surgical intervention aimed maximum tumor removal followed radiotherapy, there was marked tendency toward limited with advancing patient age. Of those younger than 65 years, 82% either surgery alone or radiotherapy alone, versus 47% years older. Only 25% older 75 underwent...
Object. Acquisition of invasive and metastatic potentials through proteinase expression is an essential event in tumor progression. Among proteinases, matrix metalloproteinases (MMPs) are thought to play a key role progression the degradation extracellular matrix. In present study, authors examined MMP-2 (gelatinase A) membrane type 1 MMP (MT1-MMP), activator zymogen MMP-2, proMMP-2, together with tissue inhibitors (TIMP-1 TIMP-2) invasion astrocytic tumors humans. Methods. Analyses...
Little is known about genetic risk factors for idiopathic normal pressure hydrocephalus (iNPH). We examined whether a copy number loss in intron 2 of the SFMBT1 gene could be shunt-responsive, definite iNPH. Quantitative and digital PCR analyses revealed that 26.0% shunt-responsive iNPH patients (n = 50) had such change, as compared with 4.2% healthy elderly 191) (OR 7.94, 95%CI: 2.82–23.79, p 1.8 x 10−5) 6.3% Parkinson's disease 32) 5.18, 1.1–50.8, 0.038). The present study demonstrates...
Sphingosine-1-phosphate (S1P) is a bioactive lipid that signals through family of G protein-coupled receptors consisting 5 members termed S1P(1-5), and it regulates cellular proliferation, migration survival. We investigated the expression role S1P in glioma. Human glioma expressed S1P(1), S1P(2), S1P(3), S1P(5) by quantitative real-time PCR analysis. Expression S1P(1) was significantly lower glioblastoma than normal brain (p < 0.01) diffuse astrocytoma 0.05). Immunoblotting showed more...
The 3-meter Timed Up and Go test (TUG) is a reliable quantitative for assessment of gait balance. We aimed to establish an optimal threshold TUG at the tap predicting outcomes 12 months after shunt surgery in patients with idiopathic normal pressure hydrocephalus (iNPH).The was measured total 151 possible iNPH before surgery. Among them, 81 underwent ventriculoperitoneal implantation (SINPHONI) 70 lumboperitoneal (SINPHONI-2). areas under curve (AUCs), sensitivities, specificities...
A 5-year-old male presented with scrotal migration of the catheter from a ventriculoperitoneal shunt manifesting as left swelling 4 months after implantation. Surgical obliteration patent peritoneal processus vaginalis that forms corridor peritoneum to scrotum was performed avoid malfunction. Review 26 reported cases including present case revealed most patients were up 18 old. Our patient oldest. Migration tended occur within 6 implantation (mean 3.8 months, median 1.0 month). Involvement...
Five recent multicenter randomized controlled trials (RCTs) have clearly shown the superiority of mechanical thrombectomy in large vessel occlusion acute ischemic stroke compared to systemic thrombolysis. Although 14 hospitals Ishikawa prefecture uninterrupted availability thrombolysis, is not available at all these hospitals. Therefore, we established a Kanazawa mobile embolectomy team (KMET), which could travel and perform reperfusion therapy. In this article, report early treatment...
Developmental venous anomalies (DVAs) are generally asymptomatic; however, they can sometimes cause central nervous disorders. Aqueductal stenosis caused by DVAs is so rare that only 14 cases have been reported to date. Moreover, most patients children or young adults, presenting with headaches consciousness disturbances, associated raised intracranial pressure. Here, we report on an 83-year-old man mimic symptoms of idiopathic normal pressure hydrocephalus (cognitive disorder, gait...
Objective: A condition that presents with recurrent embolism due to "hidden bow hunter's syndrome," a subtype of syndrome different pathogenic mechanism, is reported.
Cerebrospinal fluid shunting, including ventriculo-abdominal/atrial and lumbar-abdominal shunts, is the only treatment available for idiopathic normal pressure hydrocephalus (iNPH). Hybrid valves that combine a programmable valve an antisiphon device are being widely used of iNPH, which has significantly minimized surgical complications, such as shunt revision subdural hematomas associated with overdrainage. Development novel technologies can maintain more physiological intracranial...
<i>Background:</i> Intracranial germ cell tumors (GCTs) are rare neoplasms. Little is known about the pathogenesis of these tumors. The BCL10 gene, a proapoptotic signaling molecule involved in Apaf-1/caspase-9 death pathway, may act as tumor suppressor gene multiple types including testicular GCTs. <i>Methods:</i> To evaluate whether alterations play role genesis intracranial GCTs, we analyzed 10 pure germinomas (PGs) and nongerminomatous <i>Results:</i>...
Pseudomonas aeruginosa (P. aeruginosa) frequently causes various infections, some of which are serious and require prompt medical detection appropriate antibiotic selection. Although P. commonly exists within the nasal cavity, meningitis or ventriculitis following transsphenoidal surgery to relieve has been reported only occasionally. However, as endoscopic transnasal approach is more widely utilized for suprasellar lesions, nosocomical infection associated with cerebrospinal fluid (CSF)...
Endoscopic examination of the intra-ventricular walls is rarely performed for cases idiopathic normal pressure hydrocephalus (iNPH) since shunting first treatment option iNPH. We conducted intra-operative endoscopy during shunt surgery in patients with iNPH and compared findings their pre-operative MRI data.
A 78-year-old man, who had undergone lumboperitoneal shunt (LPS) placement for idiopathic normal-pressure hydrocephalus eight years prior, presented with intermittent claudication, lower back pain, and radicular pain on the inside of right thigh. Magnetic resonance imaging (MRI) revealed an extradural arachnoid cyst (EDAC) above lumbar catheter LPS. The EDAC compressed spinal dural sac cauda equina toward anterior side at level L3/4, triggering his clinical manifestations. LPS was removed...
Subgaleal hematomas frequently occur in children after head trauma and extend over the cranial sutures. Although conservative treatment suffices most cases, surgical removal of a subgaleal hematoma is indicated when patient presents with anemia headache associated its progressive enlargement.We present case 7-year-old boy who was medicated warfarin aspirin due to hypoplastic left ventricle fell from rock wherein he hit his frontal region. computed tomography scan revealed no intracranial...
Introduction: Vertebral Artery Stump Syndrome (VASS) has previously been reported as a mechanism of embolism to posterior circulation (PC) that is due flow stagnation caused by VA origin occlusion. We report the efficacy endovascular treatment (EVT) for VASS including novel method approach. Methods: retrospectively investigated 1381 consecutive cases ischemic stroke treated in our institution. Diagnosis was performed on PC area alone with proximal occlusion accompanied distal and without...
Revision surgeries after cerebrospinal shunt placement are sometimes unavoidable mainly because of the mechanical limitations current devices despite their technological improvements. This article discusses evidence on existing devices, basic knowledge structure and function, possible future issues.