A5083461231- Vibration and Dynamic Analysis
- Atrial Fibrillation Management and Outcomes
- Cardiac Arrhythmias and Treatments
- Magnetic Bearings and Levitation Dynamics
- Dynamics and Control of Mechanical Systems
- Cellular Automata and Applications
- Structural Health Monitoring Techniques
- Genomic variations and chromosomal abnormalities
- Esophageal Cancer Research and Treatment
- Vibration Control and Rheological Fluids
- Gastric Cancer Management and Outcomes
- Advanced Data Compression Techniques
- Video Coding and Compression Technologies
- Cerebrospinal fluid and hydrocephalus
- Sports Dynamics and Biomechanics
- Cardiac electrophysiology and arrhythmias
- Fetal and Pediatric Neurological Disorders
- Genomics and Phylogenetic Studies
- Engineering Applied Research
- Identification and Quantification in Food
- Sports Performance and Training
- Railway Engineering and Dynamics
- Advanced Adaptive Filtering Techniques
- Hydraulic and Pneumatic Systems
- Composite Structure Analysis and Optimization
Yamagata University
2015-2024
Jikei University School of Medicine
2015-2024
Fukushima Medical University
2022-2024
Nissan (Japan)
2009-2023
Katsushika Medical Center
2023
University of Hong Kong
2022
Institute of Microelectronics
2022
Chinese Academy of Sciences
2022
Toshiba (Japan)
2022
Hitachi (Japan)
2012-2022
Recent epidemiological studies reported a relationship between 24-hour ambulatory blood pressure (ABP) variability and cardiovascular events. However, the impact of ABP on small vessel disease (SVD) progression or cognitive decline in elderly has seldom been investigated community-based longitudinal studies.Subjects (n = 210) underwent monitoring, brain magnetic resonance imaging (MRI), testing at baseline 4 years later. was quantified by SD, weighted coefficient variation (CV), average real...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTComplex composition distribution of poly(3-hydroxybutyrate-co-3-hydroxyvalerate)Naoko Yoshie, Hiroyuki Menju, Hidenori Sato, and Yoshio InoueCite this: Macromolecules 1995, 28, 19, 6516–6521Publication Date (Print):September 1, 1995Publication History Published online1 May 2002Published inissue 1 September 1995https://pubs.acs.org/doi/10.1021/ma00123a018https://doi.org/10.1021/ma00123a018research-articleACS PublicationsRequest reuse...
Objective. Systemic-onset juvenile idiopathic arthritis (systemic JIA) and macrophage activation syndrome (MAS), the most devastating complication of systemic JIA, are characterized by abnormal levels proinflammatory cytokines. Interferon regulatory factor 5 (IRF5) is a member IRF family transcription factors, acts as master in genes encoding Polymorphisms IRF5 gene have been associated with susceptibility to autoimmune diseases such lupus erythematosus (SLE) rheumatoid arthritis. Our aim...
Objective Dementia is a major cause of disruption for healthy life expectancy in Japan. It has been suggested that the number teeth modifiable risk factor cognitive impairment and dementia. We therefore examined possible association between function natural artificial community-dwelling Japanese elderly individuals.
Abstract Background Hyperuricemia (HU) has been reported to be associated with a high incidence of atrial fibrillation (AF). However, the relationship between HUA and recurrent AF after catheter ablation (CA) is unclear. Methods Four hundred consecutive patients (paroxysmal/persistent [PAF/PsAF]: 200/200) who underwent initial CA were retrospectively enrolled. HU was defined as serum uric acid (SUA) level >7.0 mg/dL. We measured SUA levels 1 day before (pre‐CA) month (post‐CA). A...
Little is known about genetic risk factors for idiopathic normal pressure hydrocephalus (iNPH). We examined whether a copy number loss in intron 2 of the SFMBT1 gene could be shunt-responsive, definite iNPH. Quantitative and digital PCR analyses revealed that 26.0% shunt-responsive iNPH patients (n = 50) had such change, as compared with 4.2% healthy elderly 191) (OR 7.94, 95%CI: 2.82–23.79, p 1.8 x 10−5) 6.3% Parkinson's disease 32) 5.18, 1.1–50.8, 0.038). The present study demonstrates...
In recent years, the development of diagnostics using artificial intelligence (AI) has been remarkable. AI algorithms can go beyond human reasoning and build diagnostic models from a number complex combinations. Using next-generation sequencing technology, we identified hepatitis C virus (HCV) variants resistant to directing-acting antivirals (DAA) by whole genome full-length HCV genomes, applied these various machine-learning evaluate preliminary predictive model. genomic RNA was extracted...
Multiple system atrophy (MSA) is a sporadic disease. Its pathogenesis may involve multiple genetic and nongenetic factors, but its etiology remains largely unknown. We hypothesized that the genome of patient with MSA would demonstrate copy number variations (CNVs) in genes or genomic regions interest. To identify alterations increasing risk for MSA, we examined pair monozygotic (MZ) twins discordant phenotype 32 patients MSA.
ABSTRACT HIV-1 patients continue to remain at an abnormal immune status despite prolonged combination antiretroviral therapy (cART), which results in increased risk of non-AIDS-related diseases. Given the growing recognition importance understanding and controlling residual virus patients, additional virological markers monitor infected cells are required. However, viral replication circulating is much poorer than that lymph nodes, absence distinguish these from uninfected blood. In this...
In the purple membrane of Halobacterium salinarium , bacteriorhodopsin trimers are arranged in a hexagonal lattice. When sheets incubated at high temperature with neutral detergent, vesicularization takes place, yielding inside-out vesicles diameter 50 nm. The vesicular structure becomes unstable low temperature, where successive fusion yields crystal which is composed stacked planar membranes. X-ray crystallographic analysis reveals that honeycomb lattice each layer and neighbouring...
Idiopathic normal pressure hydrocephalus (iNPH) is clinically important as a treatable gait disturbance or preventable dementia by shunt operation. We have recently reported that approximately 1.5% of the elderly living in Japanese community showed ventriculomegaly with features iNPH on MRI (VIM), which may represent preclinical stage iNPH. The purpose present study was to identify possible genetic change VIM subjects.Eight subjects and 10 healthy individuals were examined for copy number...
We report the first known case of syphilis with simultaneous manifestations proctitis, gastritis, and hepatitis. The diagnosis syphilitic proctitis gastritis was established by demonstration spirochetes anti-Treponema pallidum antibody staining in biopsy specimens. Unusual secondary completely resolved after 4 weeks antibiotic therapy.
Midnolin (MIDN) was first discovered in embryonic stem cells, but its physiological and pathological roles are, to date, poorly understood. In the present study, we therefore examined role of MIDN detail. We found that PC12 a model neuronal localized primarily nucleus intracellular membranes. Nerve growth factor promoted gene expression, which attenuated by specific inhibitors extracellular signal-regulated kinases 1/2 5. MIDN-deficient cells created using CRISPR/Cas9 technology displayed...
Objectives One of the mechanisms early recurrence atrial fibrillation (ERAF) after AF ablation is considered to be inflammatory reaction tissue. The aim this study compare clinical significance ERAF at each stage for true between cryoballoon (CB) and radiofrequency (RF) ablation. Methods Among 798 paroxysmal patients who underwent an initial ablation, 460 (CB, n = 230; RF, 230) were selected by propensity score matching. Very (VERAF), ERAF-1M, ERAF-3M defined as 0–2, 3–30, 31–90 days more...
Pulmonary vein stenosis (PVS) after PV isolation (PVI) for atrial fibrillation (AF) is a severe complication that requires angioplasty. This study aimed to compare the reduction of cross-sectional area (PVA) and incidence PVS cryoballoon (CB)-PVI, hot balloon (HB)-PVI, or laser (LB)-PVI.