A5066458898- Cerebrospinal fluid and hydrocephalus
- Fetal and Pediatric Neurological Disorders
- Traumatic Brain Injury and Neurovascular Disturbances
- Neurosurgical Procedures and Complications
- Autoimmune Neurological Disorders and Treatments
- Genetic and Kidney Cyst Diseases
- Balance, Gait, and Falls Prevention
- Spinal Dysraphism and Malformations
- Genetic Neurodegenerative Diseases
- Advanced Neuroimaging Techniques and Applications
- Cerebrovascular and Carotid Artery Diseases
- Intracerebral and Subarachnoid Hemorrhage Research
- Dementia and Cognitive Impairment Research
- Parkinson's Disease Mechanisms and Treatments
- Neurological disorders and treatments
- Cerebral Palsy and Movement Disorders
- Cytomegalovirus and herpesvirus research
- Ion channel regulation and function
- Dysphagia Assessment and Management
- Cardiovascular Health and Disease Prevention
- Child Abuse and Related Trauma
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Amyotrophic Lateral Sclerosis Research
- RNA regulation and disease
- Viral Infections and Immunology Research
Yamagata University
2016-2025
Tohoku University
2023-2025
Yamagata University Hospital
2022
Fukushima Medical University
2014-2016
Objective Dementia is a major cause of disruption for healthy life expectancy in Japan. It has been suggested that the number teeth modifiable risk factor cognitive impairment and dementia. We therefore examined possible association between function natural artificial community-dwelling Japanese elderly individuals.
Disproportionately enlarged subarachnoid-space hydrocephalus (DESH) is a key feature for Hakim disease (idiopathic normal pressure hydrocephalus: iNPH), but subjectively evaluated. To develop automatic quantitative assessment of DESH with segmentation using combined deep learning models. This study included 180 participants (42 patients, 138 healthy volunteers; 78 males, 102 females). Overall, 159 three-dimensional (3D) T1-weighted and T2-weighted MRIs were included. As semantic...
We previously investigated the preclinical state of idiopathic normal pressure hydrocephalus (iNPH): asymptomatic ventriculomegaly with features iNPH on magnetic resonance imaging (AVIM) found in community inhabitants. The aim study was to determine how develops longitudinally.A previous longitudinal prospective community-based cohort initiated 2000. 271 70 year-old participants were followed up 2016 at age 86 years. At this time, 104 could be reached for clinical examinations and brain...
Anti-IgLON5 disease shows various neurological manifestations, of which dysautonomia is one the major symptoms and rarely improved by immunotherapy. We herein report a patient with anti-IgLON5 who showed several autonomic failures, including vocal cord palsy for four months. The presented cognitive impairments, bulbar accompanied myorhythmia in pharynx tongue, cerebellar ataxia tremor, motor neuron limbs, gastrointestinal dysfunction, orthostatic hypotension, non-rapid eye movement sleep...
Abstract Alzheimer’s disease (AD)-related primary progressive aphasia (PPA) exhibits considerable heterogeneity in clinical presentation and neuroimaging patterns. No studies have quantitatively assessed cerebral perfusion patterns or systematically evaluated the internal of linguistic features this population. This study aimed to investigate hypoperfusion elucidate their correlation with diverse patients AD-related PPA using a data-driven approach. Eleven 34 non-AD-related were categorized...
Idiopathic normal-pressure hydrocephalus (Hakim's disease) is characterized by ventricular enlargement and disproportionately enlarged subarachnoid space hydrocephalus, leading to localized brain deformation. Differentiating regional volume changes in Hakim's disease from those Alzheimer's disease, with mild cognitive impairment provides insights into disease-specific mechanisms. This study aimed identify patterns of compare them cognitively healthy individuals using an advanced artificial...
Little is known about genetic risk factors for idiopathic normal pressure hydrocephalus (iNPH). We examined whether a copy number loss in intron 2 of the SFMBT1 gene could be shunt-responsive, definite iNPH. Quantitative and digital PCR analyses revealed that 26.0% shunt-responsive iNPH patients (n = 50) had such change, as compared with 4.2% healthy elderly 191) (OR 7.94, 95%CI: 2.82–23.79, p 1.8 x 10−5) 6.3% Parkinson's disease 32) 5.18, 1.1–50.8, 0.038). The present study demonstrates...
Bidirectional reciprocal motion of cerebrospinal fluid (CSF) was quantified using four-dimensional (4D) flow magnetic resonance imaging (MRI) and intravoxel incoherent (IVIM) MRI. To estimate various CSF motions in the entire intracranial region, we attempted to integrate parameters calculated two MRI sequences. elucidate how dynamics deteriorate Hakim's disease, an age-dependent chronic hydrocephalus, were estimated from sequences assess region.
Idiopathic normal pressure hydrocephalus (iNPH) is clinically important as a treatable gait disturbance or preventable dementia by shunt operation. We have recently reported that approximately 1.5% of the elderly living in Japanese community showed ventriculomegaly with features iNPH on MRI (VIM), which may represent preclinical stage iNPH. The purpose present study was to identify possible genetic change VIM subjects.Eight subjects and 10 healthy individuals were examined for copy number...
Recent studies suggest that hemostatic and endothelial factors play a pivotal role in the development of cerebral small vessel disease (SVD). Although plasma fibrinogen is an essential factor coagulation cascade, relationship among fibrinogen, cognitive function, SVD has not been clarified community-based Asian populations. Because levels Asians have reported to be lower than these Caucasians, impact on or dementia may different from Caucasians.We performed cross-sectional study using MRI...
To quantitatively assess pathological gait, we developed a novel smartphone application for full-body human motion tracking in real time from markerless video-based images using monocular camera and deep learning. As training data learning, the original three-dimensional (3D) dataset comprising more than 1 million captured 3D of 90 humanoid characters two-dimensional COCO 2017 were prepared. The heatmap offset consisting 28 × blocks with three red-green-blue colors at 24 key points entire...
A woman started to feel intractable pain on her lower legs when she was 76. At the age of 78, diagnosed as having Parkinson’s disease (PD). The leg suspected be a symptom PD after eliminating other causes. patient also suffered from nonmotor symptoms, depression, anxiety, hot flashes, and paroxysmal sweating. Though had received pharmacotherapy including levodopa for 5 years, still symptoms referred our department. We treated with acupuncture based Chinese traditional medicine...
Distinguishing pathological gait is challenging in neurology because of the difficulty capturing total body movement and its analysis. We aimed to obtain a convenient recording with an iPhone establish algorithm based on deep learning. From May 2021 November 2022 at Yamagata University Hospital, Shiga University, Takahata Town, patients idiopathic normal pressure hydrocephalus (n = 48), Parkinson’s disease 21), other neuromuscular diseases 45) comprised group 114), control consisted 160...
To assess pathological gaits quantitatively, three-dimensional coordinates estimated with a deep learning model were converted into body axis plane projections. First, 15 healthy volunteers performed four gait patterns; that is, normal, shuffling, short-stepped, and wide-based gaits, the Three-Dimensional Pose Tracker for Gait Test (TDPT-GT) application. Second, of 47 patients idiopathic normal pressure hydrocephalus (iNPH) 92 elderly individuals in Takahata cohort assessed TDPT-GT....
How do regional brain volume ratios and cerebral blood flow (CBF, mL/min) change with aging, are there sex differences? This study aimed to comprehensively evaluate the relationships between CBF in healthy brains. The participants were volunteers who underwent three-dimensional T1-weighted MRI, time-of-flight MR angiography, four-dimensional (4D) MRI 2020 2022. was automatically segmented into 21 subregions from 3D 16 major intracranial arteries measured by 4D MRI. CBFs around circle of...
Abstract Purpose We examined whether time-course augmentation of perivascular space enlargement in the basal ganglia (BG-PVS) reflected cerebral small vessel disease (CSVD) severity by considering white matter hyperintensity lesion (WMHL) as an indicator for CSVD. Materials and methods This study population included 416 older participants from a community-based cohort. They participated magnetic resonance imaging (MRI) studies more than once during period. The grades BG-PVS WMHL were...