A5040570107- Cerebrospinal fluid and hydrocephalus
- Fetal and Pediatric Neurological Disorders
- Spinal Dysraphism and Malformations
- Traumatic Brain Injury and Neurovascular Disturbances
- Neurosurgical Procedures and Complications
- Intracerebral and Subarachnoid Hemorrhage Research
- EEG and Brain-Computer Interfaces
- Advanced Neuroimaging Techniques and Applications
- Neurological disorders and treatments
- Indoor and Outdoor Localization Technologies
- Epilepsy research and treatment
- Vascular Malformations and Hemangiomas
- Genetic and Kidney Cyst Diseases
- Parkinson's Disease Mechanisms and Treatments
- Vascular Malformations Diagnosis and Treatment
- Evacuation and Crowd Dynamics
- Blind Source Separation Techniques
- Neural dynamics and brain function
- Alzheimer's disease research and treatments
- Clusterin in disease pathology
- Tumors and Oncological Cases
- Genetic Neurodegenerative Diseases
- Animal testing and alternatives
- Underwater Vehicles and Communication Systems
- Functional Brain Connectivity Studies
Juntendo University
2016-2025
Juntendo University Hospital
2020-2024
Keio University
2010-2022
Eisai (Japan)
2021
Center for Global Health
2021
National Center for Global Health and Medicine
2021
Shinshu University
2021
Koto Hospital
2020
University of Idaho
2019
Kokusai Junior College
2016-2019
Among the various disorders manifesting dementia, gait disturbance, and urinary incontinence in elderly population, idiopathic normal pressure hydrocephalus (iNPH) is becoming of great importance. After publication first edition Guidelines for Management Idiopathic Normal Pressure Hydrocephalus 2004 (the English version was published 2008), clinical awareness iNPH has risen dramatically, number shunt surgeries increased rapidly across Japan. Clinical basic research on significantly, more...
Among the various disorders that manifest with gait disturbance, cognitive impairment, and urinary incontinence in elderly population, idiopathic normal pressure hydrocephalus (iNPH) is becoming of great importance. The first edition these guidelines for management iNPH was published 2004, second 2012, to provide a series timely, evidence-based recommendations related iNPH. Since last edition, clinical awareness has risen dramatically, basic research efforts on have increased significantly....
In this study, we propose an indoor navigation system that utilizes visible light communication technology, which employs LED lights and a geomagnetic correction method, aimed at supporting visually impaired people who travel indoors. To verify the effectiveness of system, conducted experiment targeting people. Although acquiring accurate positional information detecting directions indoors is difficult, confirmed using direction can be obtained utilizing lights, correcting values sensor...
Abstract Objectives There have been no nationwide epidemiological studies of idiopathic normal pressure hydrocephalus ( iNPH ) in Japan. Therefore, a epidemiologic survey was performed to determine the number cases and clinical characteristics by sex diagnostic level. Methods The first examined numbers that met criteria those who underwent shunt operations 2012. second gathered patients' details clarify their background characteristics. Results estimated meeting 2012 12,900, with 6,700...
Background Cognitive impairment is difficult to improve after shunt operation in patients with idiopathic normal pressure hydrocephalus (i NPH ). This study aims identify cerebrospinal fluid ( CSF ) biomarkers predictive of improvement cognitive function. Methods was conducted between J anuary 2008 and D ecember 2010 on consecutive, unselected admissions our program for the treatment clinically suspected i . Lumbar concentrations total tau (Tau), phosphorylated at threonine 181 (p‐tau),...
The aim of this study was to evaluate the water diffusivity changes along perivascular space after lumboperitoneal shunt (LPS) surgery in idiopathic normal pressure hydrocephalus.Nine patients diagnosed with hydrocephalus (iNPH; three men and six women, mean age ± SD = 75.22 5.12 years) according guidelines for iNPH Japan were included study. Post-LPS surgery, who exhibited improvement symptoms defined as responder subjects, while did not non-responder subjects. We calculated analysis (ALPS)...
In this study, we propose an indoor navigation system that utilizes visible light communication technology, which employs LED lights and a geomagnetic correction method, aimed at supporting visually impaired people who travel indoors. To verify the effectiveness of system, conducted experiment targeting people. Although acquiring accurate positional information detecting directions indoors is difficult, confirmed using direction can be obtained utilizing lights, correcting values sensor...
Leucine-rich α2-glycoprotein (LRG) is a protein induced by inflammation. It contains leucine-rich repeat (LRR) structure and easily binds with other molecules. However, the function of LRG in brain during aging neurodegenerative diseases has not been investigated. Here, we measured human (hLRG) concentration cerebrospinal fluid (CSF) observed hLRG expression post-mortem cerebral cortex. We then generated transgenic (Tg) mice that over-expressed mouse (mLRG) to examine effects mLRG...
The symptoms of idiopathic normal pressure hydrocephalus (iNPH) can be improved by shunt surgery, but prediction treatment outcome is not established. We investigated changes the corticospinal tract (CST) in iNPH before and after surgery using diffusion microstructural imaging, which infers more specific tissue properties than conventional tensor imaging. Two biophysical models were used: neurite orientation dispersion density imaging (NODDI) white matter integrity (WMTI). In both methods,...
Summary Objective Some patients with S turge‐ W eber syndrome ( SWS ) need epilepsy surgery for adequate seizure control and prevention of psychomotor deterioration. The majority have leptomeningeal angioma located over the temporal, parietal, occipital lobes. We applied posterior quadrant disconnection this type intractable seizure. evaluated efficacy procedure in development. Methods Ten who were surgically treated using quadrantectomy PQT enrolled study. Surgical outcome was analyzed as...
Cerebrospinal fluid (CSF) shunting can improve symptoms of elderly patients' idiopathic normal pressure hydrocephalus (iNPH). However, adjunctive means for confirming the diagnosis remain unavailable. We have previously reported specific increase leucine-rich alpha-2-glycoprotein (LRG) in iNPH CSF, and present study investigates its potential clinical applications.We performed CSF tap test (TT) on 90 patients (mean age 73.4 years) 52 73.5 years), evaluating symptom improvement higher...
The mechanisms of cancer cell growth and metastasis are still not entirely understood, especially from the viewpoint chemical reactions in tumours. Glycolytic metabolism is markedly accelerated cells, causing accumulation glucose (a reducing sugar) methionine (an amino acid), which can non-enzymatically react form carcinogenic substances. There speculation that this reaction produces gaseous sulfur-containing compounds tumour tissue. aims study were to clarify products investigate their...
In Japan, idiopathic normal pressure hydrocephalus (iNPH) currently is treated mainly with lumboperitoneal (LP) shunts. Our aim was to evaluate whether LP shunting via the use of Medtronic Strata NSC programmable valves as effective ventriculoperitoneal in treatment patients iNPH from perspectives safety and symptomatic improvement rate.The clinical records 51 (mean age, 75 years; males, 29), who underwent placement shunt systems were reviewed retrospectively a cohort. evaluated modified...
The aim of this study was to determine whether the improvement cerebrospinal fluid (CSF) flow dynamics by CSF shunting, can suppress oligomerization amyloid β-peptide (Aβ), measuring levels Alzheimer's disease (AD)-related proteins in before and after lumboperitoneal shunting. Lumbar from 32 patients with idiopathic normal pressure hydrocephalus (iNPH) (samples were obtained 1 year shunting), 15 AD, 12 controls analyzed for AD-related APLP1-derived Aβ-like peptides (APL1β) (a surrogate...
The 3-meter Timed Up and Go test (TUG) is a reliable quantitative for assessment of gait balance. We aimed to establish an optimal threshold TUG at the tap predicting outcomes 12 months after shunt surgery in patients with idiopathic normal pressure hydrocephalus (iNPH).The was measured total 151 possible iNPH before surgery. Among them, 81 underwent ventriculoperitoneal implantation (SINPHONI) 70 lumboperitoneal (SINPHONI-2). areas under curve (AUCs), sensitivities, specificities...
The prognosis of cognitive improvement after cerebrospinal fluid (CSF) shunting in idiopathic normal pressure hydrocephalus (iNPH) remains uncertain, with no reports on CSF biomarkers related to long-term prognosis. We performed a preliminary study biomarker protein levels for outcome prognostication two-year outcomes shunt treated iNPH 36 patients (13 women) median age 75years (IQR 69-78). included soluble amyloid precursor proteins (sAPP, sAPPα, sAPPβ), β (Aβ)1-38, Aβ1-42 and...
Purpose: Idiopathic normal pressure hydrocephalus (iNPH) and Alzheimer's disease (AD) are geriatric diseases common causes of dementia. Recently, many studies on the segmentation, detection, or classification MRI using deep learning have been conducted. The aim this study was to differentiate iNPH AD a residual extraction approach in method.
Abstract Purpose Since a case of hydrocephalus in humans considered to be caused by ciliary dysfunction was first reported Greenstone et al. 1984, numerous papers on the correlation between function and have been published. Methods We reviewed published literature primary dyskinesia causing hydrocephalus, focusing articles specifically examining relation its treatment. In addition, authors’ experience is briefly discussed. Results Full texts 16 reporting cases human (including...
OBJECT The authors' goal in this paper is to provide the first clinical, radiological, and genetic studies of panventriculomegaly (PaVM) defined by a wide foramen Magendie large cisterna magna. METHODS Clinical brain imaging data from 28 PaVM patients (including 10 5 families) were retrospectively studied. Five children included. In adult patients, age at onset was 56.0 ± 16.7 years. Tetraventricular dilation, aqueductal opening with flow void on T2-weighted images, magna (wide cerebrospinal...
Background: Idiopathic normal pressure hydrocephalus (iNPH) is commonly treated by cerebrospinal fluid (CSF) shunting. However, the long-term efficacy of shunt intervention in presence comorbid Alzheimer’s disease (AD) pathology debated. Objective: To identify AD-associated CSF biomarkers predictive shunting surgery outcomes patients with iNPH. Methods: Preoperative levels total and phosphorylated Tau (p-Tau) were measured 40 iNPH divided into low (<30 pg/mL) high (≥30 p-Tau groups...
Background and purpose: This study aimed to investigate the efficacy of cerebrospinal fluid shunt intervention for idiopathic normal pressure hydrocephalus (iNPH) using data from a nationwide epidemiological survey in Japan. Methods: We conducted cross-sectional performed Propensity score matching was used select 874 patients 1,423 aged 60 years, who were diagnosed with iNPH based on clinical guidelines following hospital visit 2012. Patients experienced an improvement at least 1 modified...