A5106034637- Cerebrospinal fluid and hydrocephalus
- Intracerebral and Subarachnoid Hemorrhage Research
- Fetal and Pediatric Neurological Disorders
- Neurosurgical Procedures and Complications
- Traumatic Brain Injury and Neurovascular Disturbances
- Spinal Dysraphism and Malformations
- Genetic and Kidney Cyst Diseases
- Intracranial Aneurysms: Treatment and Complications
- Glioma Diagnosis and Treatment
- Vascular Malformations Diagnosis and Treatment
- Alzheimer's disease research and treatments
- Neuroscience of respiration and sleep
- S100 Proteins and Annexins
- Cerebral Venous Sinus Thrombosis
- Chromatin Remodeling and Cancer
- Neurogenesis and neuroplasticity mechanisms
- Clusterin in disease pathology
- MicroRNA in disease regulation
- Cancer Mechanisms and Therapy
- Ion Transport and Channel Regulation
- Advanced Electron Microscopy Techniques and Applications
- Neurofibromatosis and Schwannoma Cases
- Nuclear Physics and Applications
- ATP Synthase and ATPases Research
- Advanced Neuroimaging Techniques and Applications
Juntendo University
2015-2024
Eisai (Japan)
2021
Center for Global Health
2021
National Center for Global Health and Medicine
2021
Shinshu University
2021
Juntendo University Hospital
2020
Neurological Surgery
2013
Leucine-rich α2-glycoprotein (LRG) is a protein induced by inflammation. It contains leucine-rich repeat (LRR) structure and easily binds with other molecules. However, the function of LRG in brain during aging neurodegenerative diseases has not been investigated. Here, we measured human (hLRG) concentration cerebrospinal fluid (CSF) observed hLRG expression post-mortem cerebral cortex. We then generated transgenic (Tg) mice that over-expressed mouse (mLRG) to examine effects mLRG...
Cerebrospinal fluid (CSF) shunting can improve symptoms of elderly patients' idiopathic normal pressure hydrocephalus (iNPH). However, adjunctive means for confirming the diagnosis remain unavailable. We have previously reported specific increase leucine-rich alpha-2-glycoprotein (LRG) in iNPH CSF, and present study investigates its potential clinical applications.We performed CSF tap test (TT) on 90 patients (mean age 73.4 years) 52 73.5 years), evaluating symptom improvement higher...
In Japan, idiopathic normal pressure hydrocephalus (iNPH) currently is treated mainly with lumboperitoneal (LP) shunts. Our aim was to evaluate whether LP shunting via the use of Medtronic Strata NSC programmable valves as effective ventriculoperitoneal in treatment patients iNPH from perspectives safety and symptomatic improvement rate.The clinical records 51 (mean age, 75 years; males, 29), who underwent placement shunt systems were reviewed retrospectively a cohort. evaluated modified...
The aim of this study was to determine whether the improvement cerebrospinal fluid (CSF) flow dynamics by CSF shunting, can suppress oligomerization amyloid β-peptide (Aβ), measuring levels Alzheimer's disease (AD)-related proteins in before and after lumboperitoneal shunting. Lumbar from 32 patients with idiopathic normal pressure hydrocephalus (iNPH) (samples were obtained 1 year shunting), 15 AD, 12 controls analyzed for AD-related APLP1-derived Aβ-like peptides (APL1β) (a surrogate...
The prognosis of cognitive improvement after cerebrospinal fluid (CSF) shunting in idiopathic normal pressure hydrocephalus (iNPH) remains uncertain, with no reports on CSF biomarkers related to long-term prognosis. We performed a preliminary study biomarker protein levels for outcome prognostication two-year outcomes shunt treated iNPH 36 patients (13 women) median age 75years (IQR 69-78). included soluble amyloid precursor proteins (sAPP, sAPPα, sAPPβ), β (Aβ)1-38, Aβ1-42 and...
Object Aquaporin (AQP) water channels play an important role in movement the central nervous system. The authors used animal model to examine relationship between AQP4 expression and spontaneously arrested hydrocephalus. Methods Congenitally hydrocephalic H-Tx (hH-Tx) rats nonhydrocephalic (nH-Tx) were study. Brain tissue sections obtained from animals both groups at 1 day, week, 4 weeks, 8 weeks of age. Sections immunostained using antibodies, was assessed. In nH-Tx group, no seen 1-day-old...
OBJECT The authors' goal in this paper is to provide the first clinical, radiological, and genetic studies of panventriculomegaly (PaVM) defined by a wide foramen Magendie large cisterna magna. METHODS Clinical brain imaging data from 28 PaVM patients (including 10 5 families) were retrospectively studied. Five children included. In adult patients, age at onset was 56.0 ± 16.7 years. Tetraventricular dilation, aqueductal opening with flow void on T2-weighted images, magna (wide cerebrospinal...
Background: Idiopathic normal pressure hydrocephalus (iNPH) is commonly treated by cerebrospinal fluid (CSF) shunting. However, the long-term efficacy of shunt intervention in presence comorbid Alzheimer’s disease (AD) pathology debated. Objective: To identify AD-associated CSF biomarkers predictive shunting surgery outcomes patients with iNPH. Methods: Preoperative levels total and phosphorylated Tau (p-Tau) were measured 40 iNPH divided into low (<30 pg/mL) high (≥30 p-Tau groups...
Background and purpose: This study aimed to investigate the efficacy of cerebrospinal fluid shunt intervention for idiopathic normal pressure hydrocephalus (iNPH) using data from a nationwide epidemiological survey in Japan. Methods: We conducted cross-sectional performed Propensity score matching was used select 874 patients 1,423 aged 60 years, who were diagnosed with iNPH based on clinical guidelines following hospital visit 2012. Patients experienced an improvement at least 1 modified...
Cell-mediated gene therapy for visceral lesions of lysosomal storage diseases is promising; however, the treatment central nervous system (CNS) remains a challenge. In this study, we generated rat amniotic epithelial cells (AEC) that overexpress and secrete human β-glucuronidase (GUSB) following transduction with an adenoviral vector encoding GUSB. The AEC were used as donor cell-mediated CNS in mice mucopolysaccharidosis type VII (MPSVII), disorder caused by inherited deficiency GUSB...
Background: Patients presenting with the classical idiopathic normal pressure hydrocephalus (iNPH) triad often show additional parkinsonian spectrum signs. Accurate differential diagnosis strongly influences long-term outcome of cerebrospinal fluid (CSF) shunting. Objective: The aim this study was to find potential CSF microRNA (miRNA) biomarkers for NPH mimics syndromes that can reliably distinguish them from iNPH patients. Methods: Two cohorts 81 patients (cohort 1, n = 55; cohort 2, 26)...
Alzheimer's disease (AD) pathology in idiopathic normal pressure hydrocephalus (iNPH) contributes to poor shunt responses. Amyloid-β 1- 42 (Aβ42) toxic conformer was recently identified with features of rapid oligomerization, strong neurotoxicity and synaptotoxicity.
Abstract BACKGROUND Treating idiopathic normal pressure hydrocephalus (iNPH) with lumboperitoneal shunts (LPSs) may cause cerebrospinal fluid (CSF) overdrainage. OBJECTIVE To investigate whether LPSs, including gravitational “add-on” and programmable valves (PPVs/+GVs), reduce complications improve outcomes. METHODS We compared PPVs/+small lumen abdominal catheters (SLs) to PPVs/+GVs using different opening pressures for supine standing positions. analyzed 115 patients iNPH in 2 consequent...
Object Some cases of compensatory hydrocephalus have been reported in which cognitive deficiency progresses despite the absence progressive ventricular dilation. In this study, differentially expressed genes compensated hydrocephalic H-Tx rat cortices were determined. A molecular mechanism that induces neuronal death cerebral cortex is proposed. Methods The 8-week-old rats with spontaneously arrested (hH-Tx) and nonhydrocephalic (nH-Tx) control subjected to cDNA microarray analysis followed...
The aim of this study was to quantitatively evaluate the function cranial diploic and spinal epidural veins as cerebrospinal fluid (CSF) drainage pathways by measuring lipocalin-type prostaglandin D synthase (PGDS) cystatin C (CysC) dissolved in blood these veins. This a prospective involving 51 consecutive patients, 31 males 20 females, who underwent 41 10 surgeries. Intraoperatively, peripheral venous blood, or samples were simultaneously collected immediately centrifuged. For all samples,...
Congenital hydrocephalus occurs with some inheritable characteristics, but the mechanisms of its development remain poorly understood. Animal models provide opportunity to identify potential genetic causes in this condition. The Hydrocephalus-Texas (H-Tx) rat strain is one most studied animal for investigating causative alterations and analyzing downstream pathogenetic congenital hydrocephalus.Comparative genomic hybridization (CGH) array on non-hydrocephalic hydrocephalic H-Tx rats was used...
We previously reported increase in leucine-rich α2-glycoprotein (LRG) concentration cerebrospinal fluid is associated with cognitive decline humans. To investigate relationship between LRG expression the brain and memory impairment, we analyzed transgenic mice overexpressing (LRG-Tg) focusing on hippocampus. Immunostaining Western blotting revealed age-related hippocampal neurons 8-, 24-, 48-week-old controls LRG-Tg. Y-maze Morris water maze tests indicated retained spatial 8- 24-week-old...
Summary A 67-year-old woman with a past history of type 2 diabetes mellitus presented worsening glycemic control. She had some acromegaly symptoms and magnetic resonance imaging demonstrated pituitary tumor. Endocrinological examination found the resting growth hormone (GH) level within normal range, but elevated insulin-like factor 1 level. 75 g oral glucose tolerance test showed inadequate suppression nadir GH levels. Acromegaly due to GH-secreting tumor was diagnosed. The patient...
Objectives Comorbidities of idiopathic normal pressure hydrocephalus (iNPH), such as Alzheimer's disease (AD) and Parkinson's spectrum (PS) disorder, can affect the long-term prognosis cerebrospinal fluid (CSF) shunting. Therefore, it is important to be able predict comorbidities in early stage disease. This study aimed iNPH using neuropsychological tests cognitive performance evaluation. Materials & Methods Forty-nine patients with possible were divided into three groups: without AD or PS...
Background Atypical teratoid/rhabdoid tumor (AT/RT) is a highly malignant embryonal brain that occurs mainly in early childhood. Although most of the tumors are characterized by inactivating mutations suppressor gene, SMARCB1, biological basis its tumorigenesis and aggressiveness still unknown. Procedure We performed high-throughput copy number variation analysis primary cell lines generated from relapsed one our patients to identify new genes involved AT/RT biology. The expression...