A5021128318- Advanced Neuroimaging Techniques and Applications
- Ion channel regulation and function
- Neuropeptides and Animal Physiology
- Advanced MRI Techniques and Applications
- Receptor Mechanisms and Signaling
- Neuroscience and Neuropharmacology Research
- MRI in cancer diagnosis
- Adipose Tissue and Metabolism
- Cerebrospinal fluid and hydrocephalus
- Nicotinic Acetylcholine Receptors Study
- Nitric Oxide and Endothelin Effects
- Eicosanoids and Hypertension Pharmacology
- Hormonal Regulation and Hypertension
- Ion Transport and Channel Regulation
- Radiomics and Machine Learning in Medical Imaging
- Marine Toxins and Detection Methods
- Pancreatic function and diabetes
- Neuroendocrine regulation and behavior
- Cancer, Stress, Anesthesia, and Immune Response
- Aldose Reductase and Taurine
- Spinal Dysraphism and Malformations
- Biochemical effects in animals
- Parkinson's Disease Mechanisms and Treatments
- Stress Responses and Cortisol
- Pain Mechanisms and Treatments
Juntendo University
2018-2025
Juntendo University Hospital
2019-2024
Juntendo University Urayasu Hospital
2024
Nagoya University
2022
Toho University
2022
Toho University Omori Medical Center
2022
Tokyo Metropolitan Tama Medical Center
2010-2021
Otsuka (Japan)
2021
Kyushu University
2021
Nihon University
2017-2018
The glymphatic system is a whole-brain perivascular network, which promotes CSF/interstitial fluid exchange. Alterations to this may play pivotal role in amyloid β (Aβ) accumulation. However, its involvement Alzheimer disease (AD) pathogenesis not fully understood. Here, we investigated the changes noninvasive MRI measurements related network patients with mild cognitive impairment (MCI) and AD. Additionally, explored associations of measures neuropsychological score, PET standardized uptake...
<h3>BACKGROUND AND PURPOSE:</h3> Synthetic FLAIR images are of lower quality than conventional images. Here, we aimed to improve the synthetic image using deep learning with pixel-by-pixel translation through conditional generative adversarial network training. <h3>MATERIALS METHODS:</h3> Forty patients MS were prospectively included and scanned (3T) acquire MR imaging created SyMRI software. Acquired data divided into 30 training 10 test datasets. A was trained generate improved from raw as...
Conventional T2-weighted (T2-WI) magnetic resonance imaging (MRI) has poor sensitivity for prostate transition-zone (TZ) cancer detection.To retrospectively evaluate the clinical value of diffusion-weighted MRI (DW-MRI) and dynamic contrast-enhanced (DCE-MRI) in combination with T2-WI diagnosis TZ cancer.Twenty-six cancers 23 patients at least one tumor (tumor size >10 mm) located predominantly were included study. Sixteen peripheral-zone (PZ) 12 PZ but without (control group) selected by...
Previous methods for the quantification of brain tissue properties by magnetic resonance imaging were mainly based on two-dimensional acquisitions and thus limited to a relatively low resolution in slice direction compared three-dimensional (3D) acquisitions. The 3D-quantification using an interleaved Look–Locker acquisition sequence with T2 preparation pulse (3D-QALAS) may allow simultaneous relaxometry parameters high spatial resolution. To evaluate bias, linearity, day-to-day...
This study aimed to discriminate between neuroinflammation and neuronal degeneration in the white matter (WM) gray (GM) of patients with Parkinson’s disease (PD) using free-water (FW) imaging. Analysis tract-based spatial statistics (TBSS) 20 PD healthy individuals revealed changes FW imaging indices (i.e., reduced FW-corrected fractional anisotropy (FAT), increased mean, axial, radial diffusivities (MDT, ADT, RDT, respectively) volume somewhat more specific WM areas compared DTI indices....
A number of MR-derived quantitative metrics have been suggested to assess the pathophysiology MS, but reports about combined analyses these are scarce. Our aim was spatial distribution parameters for white matter myelin and axon integrity in patients with relapsing-remitting MS by multiparametric MR imaging. Twenty-four 24 age- sex-matched controls were prospectively scanned synthetic 2-shell diffusion Synthetic imaging data used retrieve relaxometry (R1 R2 relaxation rates proton density)...
Quantitative synthetic magnetic resonance imaging (MRI) enables synthesis of various contrast-weighted images as well simultaneous quantification T1 and T2 relaxation times proton density. However, to date, it has been challenging generate angiography (MRA) with MRI. The purpose this study was develop a deep learning algorithm MRA based on 3D MRI raw data.Eleven healthy volunteers 4 patients intracranial aneurysms were included in study. All participants underwent time-of-flight (TOF)...
<h3>BACKGROUND AND PURPOSE:</h3> Hypertension may be related to alterations of the glymphatic system, a waste metabolite drainage system in brain. We aimed investigate analysis along perivascular space index changes elderly subjects with hypertension. <h3>MATERIALS METHODS:</h3> Diffusion-weighted images were acquired from 126 subjects, including 63 hypertension (25 men and 38 women; mean age, 72.45 years) age- sex-matched controls 72.16 years). calculated as ratio x-axis diffusivities...
Background and Objectives: Integrating large language models (LLMs) such as GPT-4 Turbo into diagnostic imaging faces a significant challenge, with current misdiagnosis rates ranging from 30–50%. This study evaluates how prompt engineering confidence thresholds can improve accuracy in neuroradiology. Methods: We analyze 751 neuroradiology cases the American Journal of Neuroradiology using customized prompts to precision. Results: Initially, achieved baseline 55.1%. By reformatting responses...
Abstract DNA polymerase θ (Pol θ) is a recently identified family A that contains an intrinsic helicase domain. Drosophila Pol mutants are hypersensitive to bifunctional crosslinking agents and exhibit elevated frequency of spontaneous chromosomal aberrations, suggesting role for in repair interstrand crosslinks the general maintenance genome stability. To investigate possible involvement tumorigenesis, we have examined its expression various normal malignant tissues. Paired tumor adjacent...
Quantitative synthetic magnetic resonance imaging (MRI) enables the determination of fundamental tissue properties, namely, T1 and T2 relaxation times proton density (PD), in a single scan. Myelin estimation brain segmentation based on these quantitative values can also be performed automatically. This study aimed to reveal changes characteristics volumes according age provide age-specific reference obtained by MRI.This was prospective healthy subjects with no history diseases scanned...