A5014743242- Nail Diseases and Treatments
- Chemical Synthesis and Reactions
- Oral and Maxillofacial Pathology
- Protein Kinase Regulation and GTPase Signaling
- Dermatology and Skin Diseases
- Melanoma and MAPK Pathways
- Synthesis and Biological Evaluation
- Synthesis of heterocyclic compounds
- Cellular Mechanics and Interactions
- Force Microscopy Techniques and Applications
- Sarcoma Diagnosis and Treatment
- Cytokine Signaling Pathways and Interactions
- Head and Neck Cancer Studies
- Microfluidic and Bio-sensing Technologies
- Chemical Synthesis and Analysis
- Bone Tumor Diagnosis and Treatments
- Head and Neck Surgical Oncology
- Cancer Diagnosis and Treatment
- Facial Trauma and Fracture Management
- Salivary Gland Tumors Diagnosis and Treatment
- Synthesis and Characterization of Heterocyclic Compounds
- Cancer Cells and Metastasis
- Wnt/β-catenin signaling in development and cancer
- RNA Interference and Gene Delivery
- Skin and Cellular Biology Research
Yao Tokushukai General Hospital
2022-2025
Nagoya City University
2025
Asahikawa Medical University
2025
Kyoto University
2001-2021
Hiroshima University
2020
The University of Texas MD Anderson Cancer Center
2011-2019
Asahi University
2014-2018
Mizuho (Japan)
2014-2017
Yokohama City University
2008-2015
Shizuoka University
2008-2015
In response to extracellular stimuli, mitogen-activated protein kinase (MAPK, also known as ERK), which localizes the cytoplasm in quiescent cells, translocates nucleus and then relocalizes again. The relocalization of nuclear MAPK was not inhibited by cycloheximide, confirming that is achieved export, but synthesis, MAPK. export leptomycin B (LMB), a specific inhibitor signal (NES)-dependent transport. We have shown MAP (MAPKK, MEK), mostly because its having NES, able shuttle between...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAminohaloborane in organic synthesis. 1. Specific ortho substitution reaction of anilinesTsutomu Sugasawa, Tatsuo Toyoda, Makoto Adachi, and Kazuyuki SasakuraCite this: J. Am. Chem. Soc. 1978, 100, 15, 4842–4852Publication Date (Print):July 1, 1978Publication History Published online1 May 2002Published inissue 1 July 1978https://pubs.acs.org/doi/10.1021/ja00483a034https://doi.org/10.1021/ja00483a034research-articleACS PublicationsRequest reuse...
While STAT3 has been validated as a target for treatment of many cancers, including head and neck squamous cell carcinoma (HNSCC), inhibitor is yet to enter the clinic. We used scaffold C188, small-molecule previously identified by us, in hit-to-lead program identify C188-9. C188-9 binds with high affinity represents substantial improvement over C188 its ability inhibit binding pY-peptide ligand, cytokine-stimulated pSTAT3, reduce constitutive pSTAT3 activity multiple HNSCC lines, anchorage...
Mitogen-activated protein kinase (MAPK) (MAPKK, also known as MEK), a direct activator for MAPK/extracellular signal-regulated kinase, localizes to the cytoplasm excluded from nucleus during signal transmission. This nuclear exclusion of MAPKK is directed by its export (NES), but physiological significance has been unknown. We have found that disruption NES dramatically potentiates ability constitutively active induce morphological changes and malignant transformation fibroblastic cells....
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAminohaloborane in organic synthesis. 2. Simple synthesis of indoles and 1-acyl-3-indolinones using specific ortho .alpha.-chloroacetylation anilinesTsutomu Sugasawa, Makoto Adachi, Kazuyuki Sasakura, Akiko KitagawaCite this: J. Org. Chem. 1979, 44, 4, 578–586Publication Date (Print):February 1, 1979Publication History Published online1 May 2002Published inissue 1 February...
The MAPK cascades regulate a wide variety of cellular functions, including cell proliferation, differentiation, and stress responses. Here we have identified novel MAP kinase (MAPKKK), termed MLTK (for MLK-like mitogen-activated protein triple kinase), whose expression is increased by activation the ERK/MAPK pathway. There are two alternatively spliced forms MLTK, MLTKα MLTKβ. When overexpressed in cells, both MLTKβ able to activate ERK, JNK/SAPK, p38, ERK5 pathways. Moreover, activated...
We have previously shown that MUPP1, which has an MRE domain and 13 PDZ domains, is expressed in epithelial cells localize at tight junctions (TJs) apical membranes. Using yeast two‐hybrid screening, we found here MUPP1 interacts with angiomotin (Amot), JEAP/Amot‐like 1 MASCOT/Amot‐like 2, refer to as Amot/JEAP family proteins. PDZ2 ‐3 were responsible for MUPP1's interaction Amot MASCOT, whereas only PDZ3 was its JEAP. All the proteins also interacted Patj, a close relative of MUPP1. The...
MUPP1 and Patj are both composed of an L27 domain multiple PDZ domains (13 10 domains, respectively) localized to tight junctions (TJs) in epithelial cells. Although is known be responsible for the organization TJs polarity, characterization lacking. In this study, we found that share several binding partners, including JAM1, ZO-3, Pals1, Par6, nectins (cell-cell adhesion molecules at adherens junctions). exhibited similar subcellular distributions, mechanisms with which they localize also...
ZO-1, ZO-2, and ZO-3 are closely related MAGUK family proteins that localize at the cytoplasmic surface of tight junctions (TJs). ZO-1 ZO-2 expressed in both epithelia endothelia, whereas is exclusively epithelia. In spite intensive studies these TJ MAGUKs, our knowledge their functions vivo, especially those ZO-3, still fragmentary. Here, we have generated mice, as well F9 teratocarcinoma cell lines, do not express by homologous recombination. Unexpectedly, ZO-3(-/-) mice were viable...
The spatiotemporal regulation of E-cadherin expression is important during body plan development and carcinogenesis. We found that Tara (Trio-associated repeat on actin) enriched in cadherin-based adherens junctions (AJs), its knockdown MDCK cells (Tara-KD cells) significantly decreases the E-cadherin. Tara-KD activates Rac1 through Trio RhoGEF, which binds to subsequently increases phosphorylation p38 Tbx3, a transcriptional repressor. Accordingly, decrease abrogated by ITX3 SB203580...
Tissue stem cells are central regulators of organ homoeostasis. We looked for a protein that is exclusively expressed and functionally involved in cell activity rapidly proliferating isthmus the stomach corpus.We uncovered specific expression Iqgap3 through immunofluorescence situ hybridisation. performed lineage tracing transcriptomic analysis +isthmus with Iqgap3-2A-tdTomato mouse model. Depletion revealed its functional importance maintenance proliferation cells. further studied...
// Xiaoli Wu 1,2,* , Mihir K. Bhayani 1,* Cristina T. Dodge 1 Milena S. Nicoloso 3 Yunyun Chen Xiaofeng Yan Makoto Adachi Ligy Thomas Chad E. Galer 4 Tilahun Jiffar Curtis R. Pickering Michael Kupferman Jeffrey N. Myers George A. Calin Stephen Y. Lai 1,5 Department of Head and Neck Surgery, University Texas M.D. Anderson Cancer Center, Houston, TX, USA 2 Division Gastroenterology, Tongji Hospital Medical College, Huazhong Science Technology, Wuhan, Hubei Province, China Experimental...
The Lucky Dragon No. 5 (Daigo Fukuryu Maru) was a Japanese tuna trawler exposed to radioactive fallout from the Castle Bravo hydrogen bomb test conducted by United States on March 1, 1954, at Bikini Atoll in Marshall Islands. All 23 crew members suffered acute radiation sickness as result of exposure. In this paper, we present case management one who underwent tooth extraction 70 years after nuclear test. Due patient's systemic exposure radiation, various complications were anticipated...