A5049258575- Glycosylation and Glycoproteins Research
- Crystallography and molecular interactions
- Organic and Molecular Conductors Research
- Analytical Chemistry and Chromatography
- Crystallization and Solubility Studies
- Molecular spectroscopy and chirality
- Electrochemical sensors and biosensors
- Cancer Treatment and Pharmacology
- Colorectal Cancer Treatments and Studies
- Carbohydrate Chemistry and Synthesis
- Molecular Junctions and Nanostructures
- Analytical Chemistry and Sensors
- Solid-state spectroscopy and crystallography
- X-ray Diffraction in Crystallography
- Organic Electronics and Photovoltaics
- Chemical Synthesis and Analysis
- Perovskite Materials and Applications
- Neuroendocrine Tumor Research Advances
- Conducting polymers and applications
- CAR-T cell therapy research
- Magnetism in coordination complexes
- Gastrointestinal motility and disorders
- Gastric Cancer Management and Outcomes
- Immunotherapy and Immune Responses
- Toxin Mechanisms and Immunotoxins
Yamagata Prefectural Shinjo Hospital
2025
Kindai University
2003-2024
Kyoto Katsura Hospital
2015-2024
Rikkyo University
1999-2024
Tokai University Hachioji Hospital
2024
Kyoto University
2011-2023
Chugoku Central Hospital
2023
The University of Tokyo
2000-2022
Tokyo University of Science
2021-2022
Osaka National Hospital
2017-2022
Perception of microbe-associated molecular patterns by host cell surface pattern recognition receptors (PRRs) triggers the intracellular activation mitogen-activated protein kinase (MAPK) cascades. However, it is not known how PRRs transmit immune signals to MAPK cascades in plants. Here, we identify a complete phospho-signaling transduction pathway from PRR-mediated pathogen We found that receptor-like cytoplasmic PBL27 connects chitin receptor complex CERK1-LYK5 and cascade. interacts with...
The first example of "light-driven chiral molecular scissors" (1), which consists 1,1',3,3'-tetraarylferrocene as a pivot part and azobenzene driving part, was synthesized. Absorption, circular dichroism (CD), 1H NMR spectral studies on the photoinduced isomerization process an enantiomer 1 agreed well with prediction by DFT calculation, where motion handles via light-driven contraction/expansion connecting strap transformed, through pivotal ferrocene unit, into open-close blade parts.
Multilayer thin films composed of a positively charged protein and cationic polymer layers can be prepared on solid surface against their electrostatic force repulsion, by depositing avidin biotin-labeled polymers [poly(ethyleneimine) (PEI), poly(allylamine) (PAA), or poly(amidoamine) (PAMAM) dendrimer] alternately repeatedly. In contrast, the film does not form when unmodified are used, confirming that strong binding between biotin is responsible for formation multilayer films. The loading...
A fluorene derivative having both bromo and formyl groups exhibited bright phosphorescence emission in common organic solvents at room temperature. The absolute quantum yield reached 5.9% chloroform 298 K. When the was incorporated into a poly(methyl methacrylate) film, similarly observed even under air temperature for over five days.
A layer-by-layer structure of enzyme multilayers composed glucose oxidase (GOx) or lactate (LOx) and ascorbate (AOx) was prepared on the surface a platinum electrode. The amperometric response to studied in presence ascorbic acid as possible interference. An alternating repeated deposition avidin biotin-labeled enzymes resulted GOx/AOx LOx/AOx multilayers. Optical gravimetric measurements based an ultraviolet−visible absorption spectroscopy quartz crystal microbalance revealed that thus...
Dietary consumption has recently been identified as a major environmental source of pro-inflammatory advanced glycation end-products (AGEs) in humans. It is disputed whether dietary AGEs represent risk to human health. Nε-(carboxymethyl)lysine (CML), representative AGE compound found food, suggested make significant contribution circulating CML levels. However, recent studies have that the intake not associated with plasma concentrations. We shown serum levels glyceraldehyde-derived...
Abstract The amplification of molecular motions so that they can be detected by the naked eye (10 7 ‐fold from ångström to millimeter scale) is a challenging issue in development mechanical devices. In this context, perfectly ordered alignment crystalline phase has advantages, as demonstrated macroscale single crystals upon photochemical transformation molecules. course our studies on thermoresponsive amphiphiles containing tetra(ethylene glycol) (TEG) moieties, we serendipitously found...
A layer-by-layer deposition of concanavalin (Con A) and glycoproteins such as glucose oxidase (GOx) horseradish peroxidase (HRP) afforded multilayer thin films on the surfaces a quartz slide platinum electrode, through biospecific complexation Con sugar residues in glycoenzymes. Lactate (LOx), which contains intrinsically no chain, was also built into assembly by being modified extrinsically with mannose residues. The enzymes formed monomolecular or sub-monomolecular layers each layer films....
We have previously shown that MUPP1, which has an MRE domain and 13 PDZ domains, is expressed in epithelial cells localize at tight junctions (TJs) apical membranes. Using yeast two‐hybrid screening, we found here MUPP1 interacts with angiomotin (Amot), JEAP/Amot‐like 1 MASCOT/Amot‐like 2, refer to as Amot/JEAP family proteins. PDZ2 ‐3 were responsible for MUPP1's interaction Amot MASCOT, whereas only PDZ3 was its JEAP. All the proteins also interacted Patj, a close relative of MUPP1. The...
MUPP1 and Patj are both composed of an L27 domain multiple PDZ domains (13 10 domains, respectively) localized to tight junctions (TJs) in epithelial cells. Although is known be responsible for the organization TJs polarity, characterization lacking. In this study, we found that share several binding partners, including JAM1, ZO-3, Pals1, Par6, nectins (cell-cell adhesion molecules at adherens junctions). exhibited similar subcellular distributions, mechanisms with which they localize also...
The synthesis, characterization, and carrier generation mechanism of self-doping in a tetrathiafulvalene (TTF) conductor, ammonium tetrathiafulvalene-2-carboxylate (TTFCOO(-)NH(4)(+)), are described together with molecular orbital characteristics. Insulating TTFCOOH changes into hole-doped conductor TTFCOO(-)NH(4)(+) conductivity sigma = 2.0 x 10(-4) S/cm (300 K), upon salt formation NH(3). A radical species, TTF(*+)COO(-)NH(4)(+), is generated via protonation the TTF moiety as demonstrated...
Voriconazole concentrations display a large variability, which cannot completely be explained by known factors. We investigated the relationships of voriconazole concentration with patient-specific variables and concomitant medication to identify clinical factors affecting clearance.A retrospective chart review trough concentration, laboratory data, in patients was performed. The concentration/dose ratio (C/D-ratio) assessed as surrogate marker total clearance dividing daily dose per kg body...
<b><i>Objecitive:</i></b> Fucosyltransferase 8 (FUT8), the only enzyme responsible for core α1,6-fucosylation of asparagine-linked oligosaccharides glycoproteins, is a vital in cancer development and progression. We examined FUT8 expression non-small cell lung cancers (NSCLCs) to analyze its clinical significance. also guanosine diphosphate-mannose-4,6-dehydratase (GMD), which imperative synthesis fucosylated oligosaccharides....
We previously generated artificial lymph node-like tertiary lymphoid organs (artTLOs) in mice using lymphotoxin α-expressing stromal cells. Here, we show the construction of transplantable and functional artTLOs by applying soluble factors trapped slow-releasing gels absence tissue organizer- (LTo) The resultant were easily removable, transplantable, capable attracting memory B T Importantly, induced a powerful antigen-specific secondary immune response, which was particularly pronounced...
The tumor suppressor p53 functions by inducing the transcription of a collection target genes. We previously attempted to identify genes microarray expression and Ch IP ‐sequencing analyses. In this study, we describe novel gene, FUCA 1 , which encodes fucosidase. Although fucosidase, α‐ l ‐1 ( 1) has been reported be lysosomal protein, detected it outside lysosomes observed that its activity is highest at physiological pH . As there association between fucosylation tumorigenesis,...
Abstract Luminescent materials responding to mechanical stimulation can visualize the strain and damage applied objects. Mechanofluorochromism is a well‐known phenomenon induced by force on fluorescent crystalline materials. However, simple application of mechanofluorochromism unsuitable for temporally spatially detecting stress in detail because state kept rather long period. Here, dynamic stress‐sensing luminescent solid material photochromic diarylethene with moiety reported. Under state,...
Background/Aim: Zolbetuximab, a CLAUDIN18.2-targeted antibody, traditionally requires inpatient administration due to potential adverse events. This study evaluated the safety and feasibility of outpatient in community cancer center setting. Patients Methods: Five patients with CLAUDIN18.2-positive advanced gastric received zolbetuximab between July November 2024. We implemented structured protocol incorporating standardized premedication, hospital-pharmacy collaboration, comprehensive...
The systematic investigation of supramolecular host systems consisting a primary amine/carboxylic acids has been performed upon changing the molecular length component. combinations enantiopure erythro-2-amino-1,2-diphenylethanol (1) and achiral benzoic acid derivatives (2a−e) were found to be effective for inclusion 1-phenylethanol (3a−d) with chiral recognition. X-ray crystallographic analyses revealed that one-dimensional (1D) helical columnar architecture was commonly constructed in...
A feeding trial was conducted in a closed system with Nile tilapia, Oreochromis niloticus, juveniles (mean initial weight, 2.66 g) to examine total replacement of menhaden fish meal (FM) distiller's dried grains solubles (DDGS), which had been used as substrate for the production black soldier fly larvae, Hermetia illucens, combination soybean (SBM) and poultry by-product (PBM), or without supplementation amino acids (AA) DL-methionine (Met), L-lysine (Lys) commercial non-amylaceous...