A5103211015- Nail Diseases and Treatments
- Plant Pathogens and Fungal Diseases
- Fungal Infections and Studies
- Acute Myeloid Leukemia Research
- Dermatology and Skin Diseases
- Hematopoietic Stem Cell Transplantation
- RNA Research and Splicing
- Peptidase Inhibition and Analysis
- Cell Adhesion Molecules Research
- RNA modifications and cancer
- T-cell and B-cell Immunology
- Fungal Biology and Applications
- Lung Cancer Treatments and Mutations
- Chronic Myeloid Leukemia Treatments
- Mesenchymal stem cell research
- Antimicrobial Peptides and Activities
- Cancer-related gene regulation
- Cancer, Hypoxia, and Metabolism
- Plant Disease Resistance and Genetics
- Monoclonal and Polyclonal Antibodies Research
- Mycobacterium research and diagnosis
- Cancer Cells and Metastasis
- Genomics and Phylogenetic Studies
- RNA and protein synthesis mechanisms
- Animal Behavior and Welfare Studies
Kanazawa Medical University
2016-2025
National Cancer Center Hospital East
2014-2025
Tokyo Metropolitan Institute of Gerontology
2025
Akita University
2016-2024
Kumamoto University
2018-2023
Dokkyo Medical University
2013-2023
Tokyo University of Science
2023
Chiba Cancer Center
2019-2022
Nara Women's University
2001-2022
Akita Industrial Technology Center
2022
Kidney fibrosis is the final common pathway of all progressive chronic kidney diseases, which diabetic nephropathy leading cause. Endothelial-to-mesenchymal transition (EndMT) has emerged as one most important origins matrix-producing fibroblasts. Dipeptidyl peptidase-4 (DPP-4) inhibitors have been introduced into market antidiabetes drugs. Here, we found that DPP-4 inhibitor linagliptin ameliorated in mice without altering blood glucose levels associated with inhibition EndMT and...
Two strains of obligately barophilic bacteria were isolated from a sample the world's deepest sediment, which was obtained by unmanned deep-sea submersible Kaiko in Mariana Trench, Challenger Deep, at depth 10,898 m. From results phylogenetic analysis based on 16S rRNA gene sequences, DNA-DNA relatedness study, and fatty acid composition, first strain (DB21MT-2) appears to be most highly similar Shewanella benthica close relatives, second (DB21MT-5) closely related genus Moritella. The...
Common molecular machineries between hematopoietic stem cell (HSC) maintenance and leukemia prevention have been highlighted. The tumor suppressor Fbxw7 (F-box WD-40 domain protein 7), a subunit of an SCF-type ubiquitin ligase complex, induces the degradation positive regulators cycle. We demonstrate that inactivation in cells causes premature depletion HSCs due to active cycling p53-dependent apoptosis. Interestingly, deletion also confers selective advantage with suppressed p53 function,...
IntroductionThe information regarding therapeutically relevant genomic alterations in small cell lung cancer (SCLC) is not well developed. We analyzed the SCLC genome using an integrative approach to stratify targetable alterations.MethodsWe performed whole exon sequencing (n = 51) and copy number analysis =47) on surgically resected tumors matched normal tissue samples from treatment-naive Japanese patients.ResultsThe demographics of 51 patients included this study were as follows: median...
Endothelial-to-mesenchymal transition (EndMT) emerges as an important source of fibroblasts. MicroRNA let-7 exhibits anti-EndMT effects and fibroblast growth factor (FGF) receptor has been shown to be in microRNA expression. The endogenous antifibrotic peptide N-acetyl-seryl-aspartyl-lysyl-proline (AcSDKP) is a substrate angiotensin-converting enzyme (ACE). Here, we found that AcSDKP inhibited the EndMT exhibited fibrotic were associated with FGF receptor-mediated anti-fibrotic program....
Abstract N-acetyl-seryl-aspartyl-lysyl-proline (AcSDKP) is an endogenous antifibrotic peptide. We found that suppression of AcSDKP and induction dipeptidyl peptidase-4 (DPP-4), which associated with insufficient levels microRNA (miR)s in kidneys, were imperative to understand the mechanisms fibrosis diabetic kidneys. Analyzing streptozotocin (STZ)-induced mouse strains, CD-1 mice fibrotic kidneys could be differentiated from less-fibrotic 129Sv by suppressing miRs (miR-29s miR-let-7s), as...
Forty-six strains of Malassezia spp. with atypical biochemical features were isolated from 366 fresh clinical isolates human subjects and dogs. Isolates obtained in this study included 2 (4.7%) lipid-dependent M. pachydermatis isolates; 1 (2.4%) precipitate-producing 6 (14.6%) non-polyethoxylated castor oil (Cremophor EL)-assimilating furfur 37 (34.3%) slooffiae that esculin hydrolyzing, 17 (15.7%) non-tolerant growth at 40 degrees C, (1.9%) assimilated polyethoxylated oil. Although their...
Abstract Ionic liquid is a kind of salt that stays in molten state even at room temperature. It does not vaporize all vacuum and facilitates electrical conductivity to the sample surfaces for observations with scanning electron microscope (SEM). In this study, we used an ionic SEM first time observe fixed human culture cells. The condition cell using wrapping sheets settings were varied elucidate optimized protocol. Compared samples prepared by conventional way, liquid‐treatment gave images...
Sorafenib is a multi-kinase inhibitor that has been proven effective for the treatment of unresectable hepatocellular carcinoma (HCC). However, its precise mechanisms action and resistance have not well established. We developed high-density fluorescence reverse-phase protein arrays used them to determine status 180 phosphorylation sites signaling molecules in 120 pathways registered NCI-Nature curated database 23 HCC cell lines. Among nodes, we found level ribosomal S6 phosphorylated at...
We launched the Wako Cohort Study in 2023 to identify individual and socio-environmental factors related extension of healthy life expectancy reduction health disparities among community-dwelling adults develop promotion care prevention strategies. This study profile aims describe design participants' at baseline. The is a prospective aged ≥ 40 years living City, Saitama Prefecture, Japan. consists two surveys: mail-in survey for persons face-to-face assessment (on-site survey) those 65...
Abstract Despite recent advances in gastric cancer therapy, chemotherapy resistance and lack of methods for selecting combination regimens remain major problems. Organoids, which provide a culture system that more closely resembles tumor cell organization than traditional lines, can be established from surgical specimens with high success rate are widely used drug sensitivity assays. In this study, we aimed to identify novel biomarker predicting multidrug using organoids (GCOs). We evaluated...
Objectives: Prostate cancer stem cells (CSCs) play an important role in cell survival, proliferation, metastasis, and recurrence; thus, removing CSCs is for complete removal. However, the mechanisms underlying CSC functions remain largely unknown, making it difficult to develop new anticancer drugs targeting CSCs. Herein, we aimed identify novel factors that regulate stemness predict prognosis. Methods: We reanalyzed 2 single-cell RNA sequencing data of prostate (PCa) tissues using Seurat....
Myelination in the visual pathway is critical for transmitting information from retina to brain. Reducing experience shortens myelin sheath length and slows conduction velocity of optic nerve. However, mechanism underlying such experience-dependent myelination unclear. Here, we found that closing both eyes, binocular deprivation (BD), during juvenile period less affects nerve than monocular (MD) via GABA signaling. RNA-seq analysis nerves MD BD mice revealed GABAergic signaling downregulated...
During postnatal life, the bone marrow (BM) supports both self-renewal and differentiation of hematopoietic stem cells (HSCs) in specialized niches. The interaction HSCs with their niches also regulates quiescence HSCs. HSC is critical to ensure lifelong hematopoiesis protect pool from myelotoxic insult premature exhaustion under conditions stress. Here we identified long-term (LT)-HSCs expressing thrombopoietin (THPO) receptor, Mpl, as a quiescent population adult BM. THPO was produced by...
Aim. To evaluate the capability of a computerized test battery for Alzheimer's disease screening which has been newly developed to provide standardized and efficient method widespread use in routine clinical community-based settings. Methods. Participants were 72 individuals diagnosed with 102 healthy elderly individuals. Both groups tested by battery. Receiver operating characteristic analysis was used examine ability differentiate between those cognitively Results. On group level,...