A5027815574- Hearing, Cochlea, Tinnitus, Genetics
- Asthma and respiratory diseases
- Vestibular and auditory disorders
- Allergic Rhinitis and Sensitization
- Biochemical Analysis and Sensing Techniques
- Ear Surgery and Otitis Media
- Neuroscience and Neuropharmacology Research
- Olfactory and Sensory Function Studies
- Tracheal and airway disorders
- Sinusitis and nasal conditions
- Respiratory and Cough-Related Research
- Advanced machining processes and optimization
- Head and Neck Cancer Studies
- Cerebral Venous Sinus Thrombosis
- Contact Dermatitis and Allergies
- Ion channel regulation and function
- Manufacturing Process and Optimization
- Ear and Head Tumors
- Horticultural and Viticultural Research
- Gut microbiota and health
- Salivary Gland Tumors Diagnosis and Treatment
- Vascular Anomalies and Treatments
- Dysphagia Assessment and Management
- Neuroendocrine Tumor Research Advances
- Voice and Speech Disorders
Hirosaki University
2016-2025
Kyoto University
2008-2025
Hirosaki University Hospital
2020
Tokushima University
2016
Institute of Biomedical Science
2016
Nagoya University
2010
University of Oslo
1996-1997
Sensitive and high-resolution immunocytochemical procedures were used to investigate the spatial organization of AMPA receptor subunits (GluR1–4) at synapse between inner hair cells afferent dendrites in rat organ Corti. This is a with special functional properties presynaptic dense body that defines center facilitates its morphometric analysis. A quantitative postembedding analysis was performed on specimens had been embedded metachrylate resin low temperature after freeze substitution....
Summary Background Cutaneous hyperpigmentation occurs in multiple conditions. In addition, many Asian women desire a lighter skin colour. Thus, there is need for the development of lightening agents. Niacinamide possible candidate. Objectives To investigate effects niacinamide on melanogenesis vitro and facial colour vivo Japanese women. Methods Melanin production was measured purified mushroom tyrosinase assay, cultured melanocytes, keratinocyte/melanocyte coculture model, pigmented...
The δ2 glutamate receptors are prominently expressed in Purkinje cells and thought to play a key role the induction of cerebellar long-term depression. synaptic subsynaptic localization δ rat cortex was investigated with sensitive high-resolution immunogold procedures. After postembedding incubation an antibody raised C-terminal peptide δ2, high gold particle densities occurred all parallel fiber synapses cell dendritic spines, whereas other were consistently devoid labeling. Among types...
Extracellular ATP has multimodal actions in the cochlea affecting hearing sensitivity. ATP-gated ion channels involved this process were characterized guinea pig cochlea. Voltage-clamped hair cells exhibited a P2 receptor pharmacology compatible with assembly of from P2X 2 subunits. Reverse transcription-PCR experiments confirmed expression 2–1 subunit mRNA isoform sensory epithelium (organ Corti); splice variant that confers desensitization, 2–2 , was predominant expressed by primary...
Using a large-scale nationwide survey database, we investigated the epidemiological characteristics for idiopathic SSNHL in Japan.The subjects this analysis were patients registered Japanese multicentre database between April 2014 and March 2016. A total of 3419 clinical obtained. Several factors associated with severity hearing impairment prognosis then investigated. Statistical was performed to clarify prognosis.There significant correlations loss diabetes mellitus, kidney disease, past...
ABSTRACT: Electron microscopic immunogold analyses have revealed a highly differentiated arrangement of glutamate receptors at excitatory synapses in the central nervous system. Studies focused on hippocampus and cerebellum shown that postsynaptic specialization is preferential site NMDA AMPA receptor expression, δ2 similarly concentrated this site. In cases colocalization (AMPA NMDA, or δ2) two types appear to be intermingled rather than segregated separate parts membrane. The different...
Abstract Aquaporins (AQPs) confer a high water permeability on cell membranes and play important parts in secretory absorptive epithelia kidney other organs. Here we investigate whether AQPs are expressed the sensory of inner ear, where precise volume regulation is crucial. By use specific antibodies it was found that ear contains AQP1 4 while being devoid detectable levels AQP2, 3 or 5. Immunofluorescence postembedding immunogold labelling revealed strictly non‐epithelial distribution AQP1,...
The development of machining and measurement systems is increasingly driven by the demands digital transformation (DX) green (GX). Addressing critical challenges across various fields, including design, manufacturing, inspection, maintenance, recycling, has become essential to meet requirements labor reduction, skill-free operation, efficiency improvement throughout entire production process. In addition, it crucial ensure social prosperity while managing resource consumption integrating...
Objectives: The aim of this study was to investigate the differences between idiopathic sudden sensorineural hearing loss (SSNHL), and acute low-tone (ALHL) using results a nationwide survey database in Japan analyze variables associated with their clinical features severity impairment, treatment, prognosis.Methods: Participants were patients registered April 2014 March 2016 multicenter epidemiological involving 30 university hospitals medical centers across Japan. Statistical analysis...
Objective . To study the clinical and pathological characteristics of patients with organized hematoma malignant features in maxillary sinuses. Subjects Methods This was a retrospective five who were treated surgically for hematoma. The preoperative CT MRI findings studied clinically. expressions CD31, CD34, periostin surgical samples investigated by immunohistochemistry. Results hematoma, such as mass expanding from sinus bone destruction, resembled those carcinoma. However, provided...
Conclusion: We investigated the localization of periostin in middle ear specimens from patients with eosinophilic otitis media (EOM) and a newly constructed animal model for EOM. Periostin-positive immunostaining was observed sections obtained EOM patients. Immunoreactivity also seen model. These results suggest that plays an important role subepithelial fibrosis Objective: The purpose present study to investigate Methods: Histological immunohistochemical analyses were carried out six...
The majority of hearing loss due to mumps presents as unilateral profound sensorineural loss, which is refractory treatment. In rare cases bilateral total deafness, cochlear implants were beneficial for speech perception. Vaccination against recommended prevent mumps-associated loss.The objective this study investigate the clinical characteristics and evaluate outcomes.The parameters analyzed under a retrospective multi-institutional design in patients diagnosed with at Otolaryngology...
Conclusion: As the periods of intratympanic injection ovalbumin (OVA) to middle ear became longer, marked eosinophil infiltration in perilymphatic space was observed. Moreover severe morphological damage organ Corti observed 28-day antigen-stimulation side. These results indicate that eosinophilic inflammation occurred inner and caused profound hearing loss. Objective: The purpose present study elucidate a new animal model otitis media (EOM) which we recently constructed. Methods: We...
Objective: To investigate the hearing prognosis of idiopathic sudden sensorineural loss (SSNHL) treated with different initial therapies.Methods: Subjects consisted patients diagnosed SSNHL within 7 days from onset and showing severe (≥60 dB), who were registered in a Japanese multicenter database between April 2014 March 2016. divided into four groups according to therapy: (1) steroids, (2) steroids + Prostaglandins (PGs), (3) intratympanic (ITS), (4) no steroids. Hearing outcomes compared...
Objectives: A nationwide epidemiological survey involving 23 hospitals in Japan was conducted and the predictive values of demographic data were examined statistically.Methods: total 642 patients from hospitals, including 20 university enrolled study. Age ranged 8 to 87 years, all diagnosed with acute low-tone sensorineural hearing loss (ALHL) between 1994 2016. Demographic for patients, such as symptoms, gender, mean age, distribution ALHL grading, collected analyzed relation prognosis...