Summary Background Cutaneous hyperpigmentation occurs in multiple conditions. In addition, many Asian women desire a lighter skin colour. Thus, there is need for the development of lightening agents. Niacinamide possible candidate. Objectives To investigate effects niacinamide on melanogenesis vitro and facial colour vivo Japanese women. Methods Melanin production was measured purified mushroom tyrosinase assay, cultured melanocytes, keratinocyte/melanocyte coculture model, pigmented...

Abstract Background Extracellular vesicles (EVs) derived from specific bacteria exert therapeutic potential on inflammatory diseases. Previous reports suggest the protective role of Odoribacter splanchnicus ( O.splanchnicus ) in bowel disease (IBD). The effect EVs (Os-EVs) and underlying mechanism IBD were surveyed here. Methods Os-EVs with ultracentrifugation before characterization by transmission electron microscopy nanoparticle tracking analysis. Based model mice induced dextran sulfate...

Lipopolysaccharide (LPS) exists in the outer membrane of Gram-negative bacteria. Colorectal normal epithelium and colorectal cancer cells situ are continuously exposed to LPS from intestinal bacteria, while little is known about influence on progression metastasis. In this study, we investigated potential role metastasis as well underlying mechanisms. We measured higher concentration tissues even with lymph node significantly enhanced cell motility promoted human dermal lymphatic endothelial...

Pyroptosis has been confirmed as a type of inflammatory programmed cell death in recent years. However, the prognostic role pyroptosis colon cancer (CC) remains unclear. Dataset TCGA-COAD which came from TCGA portal was taken training cohort. GSE17538 GEO database treated validation cohorts. Differential expression genes (DEGs) between normal and tumor tissues were confirmed. Patients classified into two subgroups according to characteristics pyroptosis-related DEGs. The LASSO regression...

The data that support the findings of this study are available on request from corresponding author. not publicly due to privacy or ethical restrictions.

Urinary bladder cancer (UBC) is one of the most common urogenital malignancies.Cancer stem-like cells (CSCs) play a vital role in tumor development and recurrence.Long noncoding RNAs (lncRNAs) are reported to influence progression via transcriptional, posttranscriptional or epigenetic regulation.Dysregulation several lncRNAs has been implicated UBC.In our study, we found that an uncharacterized lncRNA, ASAP1-IT1, was overexpressed UBC tissues compared with adjacent non-malignant tissues.High...

Background Anastomotic leakage (AL) is a major cause of postoperative morbidity and mortality in the treatment colorectal cancer. The aim this study was to investigate whether resection “dog-ears” laparoscopic anterior rectal cancer (called modified double-stapling technique, MDST) could reduce rate AL patients with middle high cancer, as compared conventional technique (DST). Methods clinical data 232 were prospectively collected from September 2015 October 2018. They randomly divided into...

The aim of this study was to explore the role sulfasalazine on proliferation and metastasis in gastric cancer by inhibition xCT. relationships between clinical characteristics xCT expression were analysed. An immunohistochemical staining assay Western blot performed among cancers normal tissues. qPCR also used evaluate mRNA protein cell eight cells, respectively. CCK-8 colony formation assays effect ability three cancers. migration invasion abilities cells assessed Transwell assay. is...

Abstract Microvascular invasion (MVI) is a critical risk factor for postoperative recurrence of hepatocellular carcinoma (HCC). This study aimed to firstly develop and validate nomograms based on MVI grade predicting recurrence, especially early overall survival in patients with early-stage HCC after curative resection. We retrospectively reviewed the data who underwent hepatectomy First Affiliated Hospital Fujian Medical University (FHFU) Mengchao Hepatobiliary (MHH). Kaplan–Meier curves...

BackgroundThis study aimed to construct a nomogram based on CAF features predict the cancer-specific survival (CSS) rates of locally advanced rectal cancer (LARC) patients.MethodsThe EPIC algorithm was employed calculate proportion CAFs. differentially expressed genes between high and low subgroups, prognostic were identified via LASSO Cox regression analyses. They then used risk signature. Moreover, GSE39582 GGSE38832 datasets for external validation. Lastly, level immune infiltration...

Abstract Purpose To evaluate the impact of log odds positive lymph nodes (LODDS) on cancer‐specific survival (CSS) in colon mucinous adenocarcinoma (MAC) patients, compared with pN stage and ratio (LNR). Methods A total 10,182 MAC patients from Surveillance, Epidemiology, End Results database were divided into training group. The external validation group included 153 Fujian Medical University Union Hospital. Cox regression method was used to identify prognostic risk factors. Nomograms...

Background: There are only limited studies on the long non-coding RNAs (lncRNAs) associated with neoadjuvant chemoradiotherapy (NCRT) response and prognosis of locally advanced rectal cancer (LARC) patients. This study identified lncRNAs NCRT in CRC patients explored their potential predictive mechanisms. Methods: The subjected LncRNA expression profiles from our previous gene chip data to LASSO a four-lncRNA signature that predicted prognosis. A Cox regression model was subsequently...

The receptor-interacting protein-1 (RIP-1) is an important molecular in inflammation signaling pathways, but the role of RIP-1 gastric cancer largely unknown. In this study, we tested expression samples and analyzed effects on prognosis patients. We cells addressed functional using a xenograft mouse model. A lentivirus-based effective siRNA vector was infected into HGC AGS cells. effect were investigated by cell proliferation assay invasion assay. Furthermore, examined RIP-1-siRNA mice with...

Abstract Background The well‐differentiated rectal neuroendocrine tumors (RNETs) can also have lymph node metastasis (LNM). Large multicenter data were reviewed to explore the risk factors for LNM in RNETs. Further, we developed a model predict of Methods In total, 223 patients with RNETs from Fujian Medical University Union Hospital, First Affiliated Hospital University, and Xiamen retrospectively enrolled. Logistic regression analysis was performed study affecting LNM, recursive...

In this work, we use nonlinear spectral imaging based on two-photon excited fluorescence (TPEF) and second harmonic generation (SHG) for analyzing the morphology of collagen elastin their biochemical variations in basal cell carcinoma (BCC), squamous (SCC) normal skin tissue. It was found work that there existed apparent differences among BCC, SCC terms thickness keratin epithelial layers, size elastic fibers, as well distribution characteristics collagen. These can potentially be used to...

Global metabolomics analysis can provide substantial information on energy metabolism, physiology, possible diagnostic biomarkers and intervention strategies for pathogens.To gain a better understanding of the mechanisms syphilis serum metabolite profiles in patients.We conducted an untargeted from 20 patients healthy controls.A total 2890 molecular features were extracted each sample, peak intensity feature was obtained. Distinct differential metabolites identified by principal component...

Purpose: To assess the value of macrophage-related biomarkers (CD163, CD68, MCSF, and CCL2) for predicting response to neo-chemoradiotherapy (NCRT) prognosis locally advanced rectal cancer (LARC). Methods: We enrolled 191 patients who underwent neoadjuvant chemoradiotherapy radical resection between 2011 2015. Tumor tissues were collected before NCRT with a colonoscope post-surgery subjected immunohistochemical analysis. Results: The expression levels lower in pathological complete (pCR)...

GRWD1 (glutamate-rich WD40 repeat containing 1) is a multifunctional protein involved in multiple cellular regulatory pathways, particularly those associated with cell growth control. represented as potential oncogene several cancers, however, the function and mechanism of development colon cancer are still unknown.IHC was used to detect expression carcinoma tissues. CCK-8, colony formation, EdU were measure proliferation after knockdown overexpression. The distribution cycle analyzed by...

The operative results of different approaches for the laparoscopic intersphincteric resection (LAISR) low rectal cancer vary, and patient characteristics associated with best outcomes each procedure have not been reported. We compared efficacy LAISR discussed surgical indications approach.We retrospectively reviewed data from 235 patients treated via October 2010 to September 2016. Patients underwent either transabdominal approach ISR (TAISR, n = 142), perineal (TPAISR, 57), or transanal...

To determine the efficacy of neoadjuvant chemoradiotherapy (NCRT) between young and old patients with locally advanced rectal cancer (LARC) in terms tumor response survival outcome.LARC undergoing NCRT radical surgery from 2011 to 2015 were included divided into: (aged ≤50 years) group >50 years). Multivariate analyses performed identify risk factors for local recurrence. Least absolute shrinkage selection operator analysis was overall survival. Predicting nomograms time-indepent receiver...