A5101413764- Bone health and osteoporosis research
- Cancer, Hypoxia, and Metabolism
- Spinal Fractures and Fixation Techniques
- Pelvic and Acetabular Injuries
- Cancer-related gene regulation
- Spine and Intervertebral Disc Pathology
- Gastric Cancer Management and Outcomes
- Epigenetics and DNA Methylation
- Metastasis and carcinoma case studies
- Galectins and Cancer Biology
- Hippo pathway signaling and YAP/TAZ
- Immune Response and Inflammation
- Radiomics and Machine Learning in Medical Imaging
- Kruppel-like factors research
- Inflammatory Biomarkers in Disease Prognosis
- Lymphatic System and Diseases
- Anorectal Disease Treatments and Outcomes
- Biomarkers in Disease Mechanisms
- Mechanisms of cancer metastasis
- Bone Metabolism and Diseases
- Genetic and phenotypic traits in livestock
- Bone health and treatments
- Cancer-related molecular mechanisms research
- Cancer Mechanisms and Therapy
- Cell Adhesion Molecules Research
Fujian Medical University
2016-2025
Affiliated Hospital of North Sichuan Medical College
2024
Chongqing Medical University
2024
North Sichuan Medical University
2024
First Affiliated Hospital of Fujian Medical University
2016-2021
Beijing Chao-Yang Hospital
2021
Beijing Chaoyang Emergency Medical Center
2021
Capital Medical University
2021
Sichuan University
2010
To compare the long-term outcomes of surgical resection and radiofrequency ablation for treatment small hepatocellular carcinoma (HCC).Radiofrequency (RFA) is a promising, emerging therapy HCC. Whether it as effective (RES) still indefinite.Two hundred thirty HCC patients who met Milan criteria were suitable to be treated by either RES or RFA entered into randomized controlled trial. The regularly followed up after 5 years (except those died). primary end point was overall survival;...
Abstract Background Osteoporosis and atherosclerosis frequently afflict older adults, recent insights suggest a deeper connection between these conditions that surpasses mere aging effects. The ratio of non-high-density to high-density lipoprotein cholesterol (NHHR) has emerged as novel lipid marker for evaluating the risk cardiovascular diseases. Nonetheless, investigations into correlation NHHR with developing osteoporosis remain unexplored. Methods We collected bone mineral density (BMD)...
Lipopolysaccharide (LPS) exists in the outer membrane of Gram-negative bacteria. Colorectal normal epithelium and colorectal cancer cells situ are continuously exposed to LPS from intestinal bacteria, while little is known about influence on progression metastasis. In this study, we investigated potential role metastasis as well underlying mechanisms. We measured higher concentration tissues even with lymph node significantly enhanced cell motility promoted human dermal lymphatic endothelial...
Glutamine (Gln) is essential for the proliferation of most cancer cells, making it an appealing target therapy. However, role Gln in gastric (GC) metabolism unknown and Gln-targeted therapy against GC remains scarce. The aim this study was to investigate relevance growth targeting.Expression transporter ASCT2 glutamine synthetase (GS) parental molecularly engineered cells or human specimens determined by RT-PCR western blot analysis immunohistochemistry. Cell survival assessed CCK-8 assay...
Gastric cancer (GC) is a very aggressive malignant tumor of the digestive system. Previous studies have shown that N-acetyltransferase 10 (NAT10) can regulate N4-acetylcytidine (ac4C) modification downstream mRNAs through certain pathways to promote progression various tumors. However, reports on regulatory effects NAT10 GC are rare. This study aimed explore potential mechanism by which regulated progression. Clinical samples were used correlation between expression and poor prognosis in...
Gastric cancer (GC) represents the fourth most common malignant neoplasm and second leading cause of death. Despite therapeutic advances in recent decades, clinical outcome remains dismal owing to fact that patients with GC show advanced disease at diagnosis current chemotherapy only confers a modest survival advantage. Identification key molecular signaling pathways involved gastric carcinogenesis progression would aid early provide rational design for targeted therapies selected GC,...
Lipopolysaccharide(LPS) could promote the progression of colorectal cancer, but specific regulatory mechanisms are largely unknown. So, this study aim to clarify that LPS upregulated VEGFR-3, which promotes cancer cells migration and invasion with a mechanism increased NF-κB bind promoter VEGFR-3.The present examined VEGFR-3 expression in tissues analyzed relationship between clinical parameters. PCR, Western blot, CCK-8, colone formation assay, Transwell assay detected promoted role process...
Ethylene oxide, a reactive epoxy compound, has been widely used in various industries for many years. However, evidence of the combined toxic effects ethylene oxide exposure on liver is still lacking.
Gastric cancer (GC) accounts for the fourth most occurring malignancy and third major cause of death. Identifying novel molecular signaling pathways participating in gastric tumorigenesis progression is pivotal rational design targeted therapies to improve advanced GC outcome. Recently, endoplasmic reticulum (ER) protein 29 (ERp29) has been shown inversely associate with primary tumor development function as a suppressor breast cancer. However, role ERp29 patients' prognosis its unknown....
The gene encoding transmembrane protein 100 (TMEM100) was first discovered to be transcribed by the murine genome. It has been recently proven that TMEM100 contributes hepatocellular carcinoma and non-small-cell lung (NSCLC). This study investigates impact of expression on gastric cancer (GC). remarkably downregulated in GC samples compared surrounding non-malignant tissues (p < 0.01). Excessive prohibited migration invasion cells without influencing their growth. However, knockdown restored...
The receptor-interacting protein-1 (RIP-1) is an important molecular in inflammation signaling pathways, but the role of RIP-1 gastric cancer largely unknown. In this study, we tested expression samples and analyzed effects on prognosis patients. We cells addressed functional using a xenograft mouse model. A lentivirus-based effective siRNA vector was infected into HGC AGS cells. effect were investigated by cell proliferation assay invasion assay. Furthermore, examined RIP-1-siRNA mice with...
Abstract Realtime trigger and localization of bursts are the key functions GECAM, an all-sky gamma-ray monitor launched on 2020 December 10. We developed a multifunctional software operating in CPU GECAM Electronic Box. This onboard has following features: high efficiency for real celestial with suppression false triggers caused by charged particle background fluctuation, dedicated algorithm optimized both short long bursts, low time latency information which is downlinked through Global...
<title>Abstract</title> Background Ethylene oxide is widely used in a number of specific industrial and medical applications due to its powerful sterilization disinfection capabilities as raw material for chemical products. However, ethylene toxic substance, prolonged exposure or at high concentrations may be hazardous human health. Animal studies have demonstrated an association between health hazards exposure. Currently, the relationship long-term osteoporosis unclear. Our aim was...
Imaging examination plays an important role in the early diagnosis of myeloma. The study focused on segmentation effects deep learning-based models CT images for myeloma, and influence different chemotherapy treatments prognosis patients. Specifically, 186 patients with suspected myeloma were research subjects. U-Net model was adjusted to segment images, then, Faster region convolutional neural network (RCNN) used label lesions. Patients divided into bortezomib group (group 1, n = 128)...
A discrepancy exists between the 7th edition guidelines of American Joint Committee on Cancer (AJCC) and 3rd Japanese treatment in terms classification No. 12a lymph nodes as regional or distant D2 lymphadenectomy for gastric cancer. The scope definition has yet to be fully elucidated. present study aimed assess appropriateness reclassifying node metastasis according survival rate outcome, provide a clear practical group retrospective analysis was performed patients with cancer who underwent...
<title>Abstract</title> Background Middle-aged and older persons are frequently afflicted with osteoporosis atherosclerosis; however, new evidence indicates a deeper relationship that goes beyond the normal aging process. One inflammatory measure has developed for evaluating risk of cardiovascular disease is uric acid to high density lipoprotein ratio (UHR).However, research on between UHR developing still awaiting. Methods Between 2011 2018, we gathered bone mineral (BMD) data from 10,983...
<title>Abstract</title> <bold>Background: </bold>The incidence of adjacent vertebral body re-fracture after percutaneous kyphoplasty (PKP) is associated with a number variables, which decreased bone mineral density one the major risk factors. Forearm (BMD) measurements are gaining attention because their convenience and validity, but there lack systematic research on specific relationship between forearm BMD PKP. <bold>Purpose: </bold>to investigate correlation PKP in osteoporotic...
Abstract Background: Although emerging cell- or animal-based evidence supports the correlation between AXIN1(Axis inhibition protein 1) and cancers，no pan-cancer analysis is accessible. Method: We thus investigate possible oncogenic characters of AXIN1 by 33 tumor types based on datasets TCGA (The cancer genome atlas) GEO (Gene expression omnibus). Result: has a high in lots tumors, obvious relevance prognosis patients, such as LICH (Liver hepatocellular carcinoma) breast cancer. observed an...
Abstract Background: The objective of this study was to assess the clinical efficacy radiotherapy combined with surgery for locally advanced gastric signet-ring-cell carcinoma (GSRCC). Methods: Clinical data patients GSRCC diagnosed by postoperative pathology from 2000-2016 were collected US Surveillance, Epidemiology and End Results (SEER) database. All enrolled divided into three groups according treatment type: alone (S; N =727), preoperative (RT+S; =138), (S+RT; =548). Results: median...