A5069348590- Hepatocellular Carcinoma Treatment and Prognosis
- Cancer, Lipids, and Metabolism
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Ferroptosis and cancer prognosis
- Immunotherapy and Immune Responses
- Immune Cell Function and Interaction
- Virus-based gene therapy research
- Plasma Applications and Diagnostics
- Cancer Immunotherapy and Biomarkers
- CAR-T cell therapy research
- Pulsed Power Technology Applications
- Immune cells in cancer
- Microbial Inactivation Methods
- Colorectal Cancer Treatments and Studies
- Nanoplatforms for cancer theranostics
- CRISPR and Genetic Engineering
Mengchao Hepatobiliary Hospital
2023-2024
Fujian Medical University
2023-2024
Fuzhou University
2022-2024
Immune checkpoint blockade based on antibodies has shown great clinical success in patients, but the transitory working manner leads to restricted therapeutic benefits. Herein, a genetically engineered adenovirus is developed as vector deliver CRISPR/Cas9 (sgCas9-AdV) achieve permanent PD-L1 gene editing with efficiency up 78.7% exemplified Hepa 1-6 liver cancer cells. Furthermore, sgCas9-AdV loaded into hydrogel made by silk fiber (SgCas9-AdV/Gel) for vivo application. The silk-gel not only...
The first-line treatment for advanced hepatocellular carcinoma (HCC) combines immune checkpoint inhibitors and antiangiogenesis agents to prolong patient survival. Nonetheless, this approach has several limitations, including stringent inclusion criteria suboptimal response rates that stem from the severe off-tumor side effects unfavorable pharmacodynamics pharmacokinetics of different drugs delivered systemically. Herein, we propose a single-agent smart nanomedicine-based mimics therapeutic...
Abstract Microvascular invasion (MVI) is a critical risk factor for postoperative recurrence of hepatocellular carcinoma (HCC). This study aimed to firstly develop and validate nomograms based on MVI grade predicting recurrence, especially early overall survival in patients with early-stage HCC after curative resection. We retrospectively reviewed the data who underwent hepatectomy First Affiliated Hospital Fujian Medical University (FHFU) Mengchao Hepatobiliary (MHH). Kaplan–Meier curves...
Abstract In this work, we proposed nµPEF, a novel pulse configuration combining nanosecond and microsecond pulses (nµPEF), to enhance tumor ablation in irreversible electroporation (IRE) for oncological therapy. nµPEF demonstrated improved efficacy inducing immunogenic cell death, positioning it as potential candidate next‐generation ablative However, the immune response elicited by alone was insufficient effectively suppress distant tumors. To address limitation, developed PPR@CM‐PD1,...
Abstract Background: This is the first study to develop and evaluate a predictive model based on microvascular invasion (MVI) classification for early recurrence survival after curative hepatectomy in patients with early-stage hepatocellular carcinoma (HCC). Methods: The database of HCC who underwent First Affiliated Hospital Fujian Medical University Xiamen were retrospectively reviewed. Kaplan-Meier curves Cox proportional hazards regression models used analyze disease-free (DFS) overall...
Abstract Background: Hepatocellular carcinoma (HCC) is among the most frequent causes of cancer-related deaths worldwide. Although predictive models for postoperative early recurrence in patients with HCC have been established, this first study to develop and evaluate a model based on microvascular invasion classification survival after curative hepatectomy early-stage HCC. Methods: The database who underwent First Affiliated Hospital Fujian Medical University Xiamen was retrospectively...