Photodynamic therapy (PDT), using a combination of chemical photosensitizers (PS) and light, has been successfully applied as noninvasive therapeutic procedure to treat tumors by inducing apoptosis or necrosis cancer cells. However, most current clinically used PS have suffered from the instability in physiological conditions which lead low photodynamic efficacy. Herein, highly biocompatible poly(dopamine) (PDA) nanoparticle conjugated with Chlorin e6 (referenced PDA-Ce6 nanosphere) was...

Multifunctional theranostic nanoparticles represent an emerging agent with the potential to offer extremely sensitive diagnosis and targeted cancer therapy. Herein, we report synthesis characterization of a multifunctional (referred as LA-LAPNHs) for magnetic resonance imaging/computed X-ray tomography (MRI/CT) dual-mode imaging photothermal therapy hepatocellular carcinoma. The LA-LAPNHs were characterized having core–shell structure gold (AuNPs)@polydopamine (PDA) inner core, indocyanine...

In this paper, a core–shell nanocomposite of clusters superparamagnetic iron oxide nanoparticles coated with poly(dopamine) (SPION clusters@PDA) is fabricated as magnetic field-directed theranostic agent that combines the capabilities highly sensitive resonance imaging (MRI) and photothermal cancer therapy. The concentrated SPION cluster core suitable for MRI due to its properties, coating layer can induce cell death under near-infrared (NIR) laser irradiation because conversion ability PDA....

Abstract Photodynamic therapy (PDT) usually aggravates tumor hypoxia, which promotes the survival and metastasis of residue cancer cells; furthermore, although PDT‐induced immunogenic death cells can induce host antitumor responses, such responses are generally weak not enough to eliminate cells. Here, metal–organic framework (MOF)‐based nanoparticles combine PDT, antihypoxic signaling, CpG adjuvant as an in situ vaccine boost anticancer after PDT designed. The MOF‐based self‐assembled from...

A photosensitizer-loaded magnetic nanobead with surface coated a cancer cell membrane to enhance MR/NIR fluorescence imaging and PDT efficacy.

Efficient and cancer cell-targeted delivery of photosensitizer (PS) therapeutic protein has great potentiality for improving the anticancer effects. Herein, zeolitic imidazolate framework-8 (ZIF-8) nanoparticles, one most attractive metal–organic framework materials, were used coencapsulating chlorin e6 (Ce6, a potent PS) cytochrome c (Cyt c, apoptosis inducer); then nanoparticle was subsequently decorated with hyaluronic acid (HA) shell to form cell-active targeted nanoplatform (Ce6/Cyt...

Abstract Semiconducting conjugated polymer nanoparticles (SPNs) represent an emerging class of phototheranostic materials with great promise for cancer treatment. In this report, low-bandgap electron donor–acceptor (D–A)-conjugated SPNs surface cloaked by red blood cell membrane (RBCM) are developed highly effective photoacoustic imaging and photothermal therapy. The resulting RBCM-coated SPN (SPN@RBCM) displays remarkable near-infrared light absorption good photostability, as well high...

Abstract The therapeutic efficacy of natural killer (NK) cells‐based immunotherapy is greatly related with the survival transplanted NK cells. However, no effective strategy was reported to monitor cell viability in adoptive vivo. Herein, we develop a ratiometric NIR‐II fluorescence imaging quantitively track and visualize vivo real‐time. nanoprobe consists lanthanide‐based down‐conversion nanoparticles (DCNP) coated IR786s, reactive oxygen species (ROS) sensitive NIR dye, which directly...

Ion-interference therapy, which utilizes ions to disturb intracellular biological processes, provides inspiration for tumor therapy. Artificially reversing osmotic pressure by transporting large amounts of physiological cells is a straightforward yet low-toxic strategy ion-interference However, it hard achieve due the serious limitations single-ion delivery. Herein, we skillfully deliver NaCl nanocrystals sites and sequentially realize explosive release Na+/Cl– inside utilizing...

Abstract Red blood cells (RBCs) have recently emerged as promosing candidates for cancer treatment in terms of relieving tumor hypoxia and inducing oxidative damage against cells, but they are still far from satisfactory due to their limited oxygen transport reactive species generation rate tissue. Herein, artificial RBCs (designated FTP@RBCM) with radical storm production ability were developed oncotherapy through multidimensional reactivity pathways Fe-protoporphyrin-based hybrid...

Semiconducting polymer dot micelles for MRI/photoacoustic imaging and single-laser-induced PDT/PTT therapy.

This study describes smart Cu(II)-aptamer complexes based gold nanoplatform for tumor micro-environment triggered programmable prodrug release, in demand photodynamic therapy and aggregation induced photothermal ablation of hepatocellular carcinoma. The is consist monodispersed nanoparticle (GNP) that binding to HCC cell specific targeting aptamers (TLS11a) through Au-S bond; the aptamer labeled with Ce6 at 5'end coordinated Cu(II) (GA)10 repeating bases load AQ4N 3' end. In normal...

The tumor hypoxic environment as well photodynamic therapy (PDT)-induced hypoxia could severely limit the therapeutic efficacy of traditional PDT. Fortunately, smart integration hypoxia-responsive drug delivery system with PDT might be a promising strategy to enhance efficiency that is hindered by environment. Herein, novel azobenzene (AZO) containing conjugated polymers (CPs)-based nanocarriers (CPs-CPT-Ce6 NPs) was constructed for combination chemotherapy, release light. polymer chains,...

We prepared novel conjugated polymer based NIR-II nanoparticles, which display extremely high photothermal conversion efficiency (65%). Both in vitro and vivo investigations revealed that the as-prepared nanoparticles exhibit excellent theranostic properties including an cancer cell killing ability, admirable tumor elimination (100%) a remarkable photoacoustic imaging contrast enhancing ability.

Prerelease of RNA molecules than chemotherapeutic drugs with a sufficient interval is vital prerequisite for RNA/drug co-delivery strategy to overcome multidrug resistance (MDR) cancer cells, but how precisely control their release at different time points still grand challenge up now. This study aims on-demand remotely manipulate and drug in real through single delivery system sequentially play respective roles optimizing enhancing synergistic antitumor effects. To this end, photoresponsive...

MRI-guided photothermal therapy is becoming a more widely accepted minimally invasive technique.

The nanosized metal–organic particles (NMOPs) recently have attracted tremendous attentions in biomedical applications. However, few studies developed nanoparticles as near-infrared (NIR) II phototherapeutic agents and Fenton-like for cancer theranostics. Herein, directly using organic dye Cu(II)-ion complexes to construct NMOPs, dual-mode therapeutic agent PA imaging-guided photochemotherapy NIR window, is reported. NMOPs are simply an assembly of Cu(II) ion tetrahydroxyanthraquinone (THQ)...

We have integrated the pH/hypoxia-triggered Fe(<sc>iii</sc>)-banoxantrone (AQ4N) prodrug and semiconducting polymer dots (SPs) for programmable triggered cancer photothermal-chemotherapy.

A versatile nanotheranostic agent of PB@PDA@PEG-FA-DOX was fabricated for active-targeting and MRI-guided combinatorial chemo/photothermal therapy cancer.

Abstract A novel metal–organic particle (MOP) based nanodrug formed by mild self‐assembly of chemotherapeutic drugs, including banoxantrone and doxorubicin, through Cu(II)‐mediated coordination effects, is reported. In this nanodrug, Cu(II) acts as a bridge to join AQ4N DOX, then, [‐AQ4N‐Cu(II)‐(DOX) 2 ‐Cu(II)‐] n complexes forms nanosized MOPs (referred ADMOPs) multiple interactions host–metal–guest coordination, hydrophobic interactions, π‐stacking, van der Waals force. The ADMOPs reported...

The low tissue penetration depth of external excitation light severely hinders the sensitivity fluorescence imaging (FL) and efficacy photodynamic therapy (PDT) in vivo; thus, rational theranostic platforms that overcome limit are urgently needed. To this crucial problem, we designed a self-luminescing nanosystem (denoted POCL) with near-infrared (NIR) emission singlet oxygen (1O2) generation abilities utilizing an intraparticle relayed resonance energy transfer strategy. Methods:...

Abstract Although tumor‐specific neoantigen‐based cancer vaccines hold tremendous potential, it still faces low cross‐presentation associated with severe degradation via endocytosis pathway. Herein, a thiolated nano‐vaccine allowing direct cytosolic delivery of neoantigen and Toll like receptor 9 agonist CpG‐ODN is developed. This approach capable bypassing the endo‐/lysosome degradation, increasing uptake local concentration to activate antigen‐presenting cells, significantly strengthening...

The low bioavailability of photosensitizers (PSs) and the hypoxia nature tumors often limit efficacy current photodynamic therapy (PDT). Therefore, improving utilization three essential components (PS, light, O2) in will enhance PDT substantially. Herein, we have developed a red blood cell (RBC) biomimetic theranostic nanovesicle (named SPN-Hb@RBCM) with improved photostability, accumulation PSs, oxygen self-supply ability to upon near-infrared (NIR) laser irradiation. Such was prepared by...