A5041498215- Nanoplatforms for cancer theranostics
- Immunotherapy and Immune Responses
- CAR-T cell therapy research
- Immune Cell Function and Interaction
- Cancer Immunotherapy and Biomarkers
- Liver physiology and pathology
- RNA Interference and Gene Delivery
- Mesenchymal stem cell research
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Immune cells in cancer
- Liver Disease Diagnosis and Treatment
- Organ Transplantation Techniques and Outcomes
- Nanoparticle-Based Drug Delivery
- Tissue Engineering and Regenerative Medicine
- Advanced Nanomaterials in Catalysis
- Advanced biosensing and bioanalysis techniques
- Cancer Research and Treatments
- Cancer, Hypoxia, and Metabolism
- Extracellular vesicles in disease
- Adipose Tissue and Metabolism
- Nanowire Synthesis and Applications
- 3D Printing in Biomedical Research
- Supramolecular Self-Assembly in Materials
- Quinazolinone synthesis and applications
Mengchao Hepatobiliary Hospital
2016-2025
Fujian Medical University
2016-2025
Fuzhou University
2017-2025
Fujian Agriculture and Forestry University
2025
State Council of the People's Republic of China
2021
First Affiliated Hospital of Fujian Medical University
2020
Abstract Herein, we propose an aptamer‐equipping strategy to generate specific, universal and permeable (SUPER) NK cells for enhanced immunotherapy in solid tumors. were chemically equipped with TLS11a aptamer targeting HepG2 PDL1‐specific without genetic alteration. The dual aptamer‐equipped exhibited high specificity tumor cells, resulting higher cytokine secretion apoptosis/necrosis compared parental or single cells. Interestingly, induced remarkable upregulation of PDL1 expression...
Abstract Hepatocellular carcinoma (HCC) commonly emerges in an immunologically “cold” state, thereafter protects it away from cytolytic attack by tumor‐infiltrating lymphocytes, resulting poor response to immunotherapy. Herein, acidic/photo‐sensitive dendritic cell (DCs)‐based neoantigen nano‐vaccine has been explored convert tumor immune state into “hot”, and remodel tumor‐associated neutrophils potentiate anticancer for enhancing immunotherapy efficiency. The is constructed SiPCCl 2...
The rational design of nanoplatforms to bypass reticuloendothelial system (RES) clearance, enhance spatiotemporal controllability, and boost host immune responses achieve synergized tumor-targeted therapeutic purpose is highly desired. Herein, a biomimetic nanosystem developed for in situ delivery singlet oxygen (1O2) carbon monoxide (CO) response exogenous stimulus ultrasound (US) endogenous hydrogen peroxide (H2O2) tumor microenvironment, respectively. Taking advantages homing RES evasion...
Abstract Background Adipose tissue-derived mesenchymal stem cells (ADSCs) are promising candidates for regenerative medicine. However, long-term in vitro passaging leads to stemness loss and cell senescence of ADSCs, resulting failure ADSC-based therapy. Methods In this study, ADSCs were treated with low dose antioxidants (reduced glutathione melatonin) anti-aging protection properties the passaging, functions including senescence, migration, multidirectional differentiation potential, ROS...
Abstract The therapeutic efficacy of natural killer (NK) cells‐based immunotherapy is greatly related with the survival transplanted NK cells. However, no effective strategy was reported to monitor cell viability in adoptive vivo. Herein, we develop a ratiometric NIR‐II fluorescence imaging quantitively track and visualize vivo real‐time. nanoprobe consists lanthanide‐based down‐conversion nanoparticles (DCNP) coated IR786s, reactive oxygen species (ROS) sensitive NIR dye, which directly...
Prerelease of RNA molecules than chemotherapeutic drugs with a sufficient interval is vital prerequisite for RNA/drug co-delivery strategy to overcome multidrug resistance (MDR) cancer cells, but how precisely control their release at different time points still grand challenge up now. This study aims on-demand remotely manipulate and drug in real through single delivery system sequentially play respective roles optimizing enhancing synergistic antitumor effects. To this end, photoresponsive...
Although photothermal therapy (PTT) is preclinically applied in solid tumor treatment, incomplete removal of PTT and heat endurance cells induces significant relapse after therefore lowering the therapeutic efficiency PTT. Herein, a programmable strategy that integrates agents (PTAs), DNAzymes, artificial engineered natural killer (A-NK) for immunotherapy hepatocellular carcinoma (HCC) designed. The novel PTAs, termed as Mn-CONASHs, with 2D structure are synthesized by coordination...
Abstract As a stimulator of interferon gene (STING), cyclic dinucleotide activates broad cellular immune response for anti‐cancer immunotherapy (CIT). However, the inherent instability 2′ 3′‐cyclic‐GMP‐AMP (cGAMP) with poor targeting, rapid clearance, and inefficient transport to cytoplasm seriously hinders cGAMP potency. Here, thiolated Mn 2+ coordinated nanovaccine (termed as Mn‐cGAMP NVs) enable direct cytosolic co‐delivery potentiate antitumor is presented. In NVs, fixation ions not only...
Abstract Although tumor‐specific neoantigen‐based cancer vaccines hold tremendous potential, it still faces low cross‐presentation associated with severe degradation via endocytosis pathway. Herein, a thiolated nano‐vaccine allowing direct cytosolic delivery of neoantigen and Toll like receptor 9 agonist CpG‐ODN is developed. This approach capable bypassing the endo‐/lysosome degradation, increasing uptake local concentration to activate antigen‐presenting cells, significantly strengthening...
Herein, we integrate the Hepa1–6 liver cancer-specific neoantigen, toll-like receptor 9 agonist and stimulator of interferon genes by silk-hydrogel package, combine with TIM-3 blockade to elicit robust antitumor immunity for effectively suppressing orthotopic hepatocellular carcinoma (HCC) progression. Unlike intradermal injection simple mixed components short-term immune protection, neoantigen immunotherapeutic-gels evoke long-term protection achieve significant prophylactic therapeutic...
Abstract Tracking and monitoring of cells in vivo after transplantation can provide crucial information for stem cell therapy. Magnetic resonance imaging (MRI) combined with contrast agents is believed to be an effective non-invasive technique tracking living bodies. However, commercial superparamagnetic iron oxide nanoparticles (SPIONs) applied label suffer from shortages such as potential toxicity, low labeling efficiency enhancing. Herein, the adipose tissue-derived (ADSCs) were...
Rationale: T-cell based immunotherapy increasingly shows broad application prospects in cancer treatment, but its performance solid tumors is far from our expectation, partly due to the re-inhibition of infiltrated T cells by immunosuppressive tumor microenvironment. Here we presented an artificial synthetic optogenetic circuit control immune responses engineered on demand for promoting and enhancing therapeutic efficiency immunotherapy. Methods: We designed synthesized blue-light inducible...
Although it has been preclinically suggested that adipose tissue-derived mesenchymal stem cell (ADSC)-based therapy could effectively treat chronic liver diseases, the hepatic engraftment of ADSCs is still extremely low, which severely limits their long-term efficacy for diseases. This study was designed to investigate impact antioxidant preconditioning on efficiency and therapeutic outcomes ADSC transplantation in fibrotic mice.Liver fibrosis model established by using intraperitoneal...
Increasing evidence has demonstrated the essential role of inflammatory micro-environment in tumorigenesis and tumor progression. Some cancer cells maintain typical stemness properties and, with capacity self-renewal, are thought to be crucial for initiation maintenance tumors as well their metastasis. Although both played roles development, currently it is still unclear whether how promotes properties. Here, we show first that metastatic potential hepatocellular carcinoma (HCC) via...
Background Collecting duct carcinoma (CDC) of the kidney is a rare and highly aggressive malignant tumor with worst prognosis among all renal cancers. Nevertheless, first-line treatments, including chemotherapy target therapy, usually show poor response to CDC. Recent studies have suggested that immunotherapy targeting personal tumor-specific neoantigens could be promising strategy for several solid However, whether it has therapeutic potential in CDC remains unclear. Case presentation Here,...
A highly stable multifunctional aptamer was prepared for strengthening antitumor immunity through a dual immune checkpoint blockade of CTLA-4 and PD-L1.
It is well established that natural killer (NK) cells can be used as an alternative candidate of T for adoptive cell therapy (ACT) due to its high killing capacity, off-the-shelf utility, and low toxicity. Though NK provide rapid potent immune effects, they still suffer from insufficient infiltration tumor immunosuppression environment, which result in unsatisfactory therapeutic efficiency. Herein, a highly stable CD16/PD-L1 bi-specific aptamer (defined CP-bi-apt) with affinity selectivity...
Abstract Growing evidences have proved that tumors evade recognition and attack by the immune system through escape mechanisms, PDL1/Pbrm1 genes a strong correlation with poor response or resistance to checkpoint blockade (ICB) therapy. Herein, multifunctional biomimetic nanocarrier (siRNA‐CaP@PD1‐NVs) is developed, which can not only enhance cytotoxic activity of cells blocking PD1/PDL1 axis, but also reduce tumor via Pbrm1/PDL1 gene silencing, leading significant improvement in...
The type VI secretion system (T6SS) has recently been demonstrated to mediate interbacterial competition and discriminate between self nonself. T6SS(+) bacteria employ toxic effectors inhibit rival cells concurrently use effector cognate immunity proteins protect their sibling cells. pairs (E-I pairs) endow the with a great advantage in niche competition. Tle4-Tli4 (PA1510-PA1509) is newly identified E-I pair that controlled by H2-T6SS Pseudomonas aeruginosa. Tle4 exhibits phospholipase...
Type 2 diabetes (T2D) is closely associated with liver fibrosis, but no effective treatments are currently available. This study was designed to investigate the therapeutic effects of ADSCs on insulin resistance, hyperglycemia, and fibrosis T2D rats.We first established a rat model by using combination high-fat diet (HFD), low-dose streptozotocin (STZ), carbon tetrachloride (CCl4). Subsequently, rats were administrated tail vein injection PBS or ADSCs, respectively. Thereafter, resistance...
Non‑alcoholic fatty liver disease (NAFLD) is one of the major causes chronic injury affecting general health various populations. In present study, adipose tissue‑derived stem cells (ADSCs), which were isolated from tissues Sprague‑Dawley rats, transplanted into high‑fat‑diet‑induced NAFLD rats via portal vein to attenuate progression NAFLD. The results demonstrated that ADSC transplantation reduced serum levels alanine aminotransferase, total bilirubin, cholesterol, triglycerides and acids,...
Currently, photoresponsive nanomaterials are particularly attractive due to their spatial and temporal controlled drug release abilities. In this work, we report a lipid-polymer hybrid nanoparticle for remote delivery of anticancer drugs. This comprises three distinct functional components: (i) poly(D,L-lactide-co-glycolide) (PLGA) core encapsulate doxorubicin; (ii) soybean lecithin monolayer at the interface shell act as molecular fence prevent leakage; (iii) polymeric with anti-biofouling...
Non-alcoholic fatty liver disease (NAFLD) is the most common cause of injury and seriously affects human health. In present study, we aimed to investigate whether adipose tissue-derived stem cell (ADSC) transplantation in combination with dietary modification was capable reversing progression NAFLD. After establishing a rat model NAFLD by feeding them high-fat diet (HFD), ADSCs were transplanted via portal vein into rats HFD-induced NAFLD, simultaneously fed modified diet. Thereafter, gross...