A5017537924- Advanced biosensing and bioanalysis techniques
- Nanoplatforms for cancer theranostics
- Advanced Nanomaterials in Catalysis
- CRISPR and Genetic Engineering
- Ubiquitin and proteasome pathways
- Electrochemical sensors and biosensors
- Endoplasmic Reticulum Stress and Disease
- Sulfur Compounds in Biology
- Epigenetics and DNA Methylation
- Luminescence and Fluorescent Materials
- Carbon and Quantum Dots Applications
- Enzyme function and inhibition
- Peptidase Inhibition and Analysis
- Nanoparticle-Based Drug Delivery
- Quinazolinone synthesis and applications
- Cancer-related Molecular Pathways
- Glycosylation and Glycoproteins Research
- Histone Deacetylase Inhibitors Research
- Polyamine Metabolism and Applications
- RNA Interference and Gene Delivery
- Retinoids in leukemia and cellular processes
- Molecular Sensors and Ion Detection
- Photodynamic Therapy Research Studies
- Pluripotent Stem Cells Research
- Cancer Mechanisms and Therapy
Mengchao Hepatobiliary Hospital
2018-2021
Fujian Medical University
2018-2021
Fujian Agriculture and Forestry University
2018-2019
Fujian Institute of Research on the Structure of Matter
2017-2019
Chinese Academy of Sciences
2017-2019
Sun Yat-sen University
2019
Fuzhou University
2017
Prerelease of RNA molecules than chemotherapeutic drugs with a sufficient interval is vital prerequisite for RNA/drug co-delivery strategy to overcome multidrug resistance (MDR) cancer cells, but how precisely control their release at different time points still grand challenge up now. This study aims on-demand remotely manipulate and drug in real through single delivery system sequentially play respective roles optimizing enhancing synergistic antitumor effects. To this end, photoresponsive...
Rationale: T-cell based immunotherapy increasingly shows broad application prospects in cancer treatment, but its performance solid tumors is far from our expectation, partly due to the re-inhibition of infiltrated T cells by immunosuppressive tumor microenvironment. Here we presented an artificial synthetic optogenetic circuit control immune responses engineered on demand for promoting and enhancing therapeutic efficiency immunotherapy. Methods: We designed synthesized blue-light inducible...
Abstract Poor prognosis of hepatocellular carcinoma (HCC) patients is frequently associated with rapid tumor growth, recurrence and drug resistance. MT1G a low-molecular weight protein high affinity for zinc ions. In the present study, we investigated expression MT1G, analyzed clinical significance observed effects overexpression on proliferation apoptosis HCC cell lines in vitro vivo. Our results revealed that was significantly downregulated tissues, could inhibit as well enhance cells. The...
Increasing evidence has demonstrated the essential role of inflammatory micro-environment in tumorigenesis and tumor progression. Some cancer cells maintain typical stemness properties and, with capacity self-renewal, are thought to be crucial for initiation maintenance tumors as well their metastasis. Although both played roles development, currently it is still unclear whether how promotes properties. Here, we show first that metastatic potential hepatocellular carcinoma (HCC) via...
Identification of new genetic pathways or molecular targets that sensitize cancer cells to chemotherapeutic drugs may improve the efficacy current chemotherapy. Here, we report downmodulation UHRF1 (ubiquitin‐like with PHD and RING finger domains 1) in retinoblastoma (RB) increases sensitivity histone deacetylase (HDAC) inhibitors, augmenting apoptotic cell death. We found depletion downregulates two redox‐responsive genes GSTA4 (glutathione S ‐transferase α4) TXN2 (thioredoxin‐2) RB cells,...
Herein, a cancer cell specific targeting nanocomplex which combines photodynamic therapy with chemotherapy through precisely responding to the intracellular tumor-related mRNA is presented.
Potassium permanganate (KMnO4) is one of the most important oxidants, which plays roles in many fields. Here, we found that KMnO4 could directly induce oxidation 3,3',5,5'-tetramethylbenzidine (TMB) to generate an oxidized product with a color change. This redox reaction highly efficient, and 1 μM enough cause detectable changes absorbance signal. Meanwhile, this very fast generated blue can stabilize for relatively long period, has great advantages practical applications. Since hydrogen...
A MnO<sub>2</sub>nanosheets–<italic>o</italic>-phenylenediamine (OPDA) oxidative system was developed for detecting ALP activity selectively, sensitively and conveniently.
Abstract Early detection and intervention are key strategies to reduce mortality, increase long-term survival, improve the therapeutic effects of hepatocellular carcinoma (HCC) patients. Herein, isobaric tag for relative absolute quantitation (iTRAQ)-based quantitative proteomic strategy was used study secretomes in conditioned media from HCC cancerous tissues, surrounding noncancerous distal tissues identify diagnostic prognostic biomarkers HCC. In total, 22 49 dysregulated secretory...
Early formation of portal vein tumor thrombosis (PVTT) is a key characteristic hepatocellular carcinoma (HCC) metastasis, but to date, the aetiology PVTT in HCC metastasis largely unknown. We aim find highly sensitive and specific biomarkers for prediction prognosis.We used isobaric tags relative absolute quantitation (iTRAQ) based quantitative phosphoproteomics approach investigate molecular signatures with primary tissues, surrounding non-cancerous tissues tissues. The different proteome...
Objective 293T cells with Ku80 knockout were constructed using clustered regularly interspaced short palindromic repeats/clustered repeats-associated protein9 (CRISPR/Cas9) technique, and the effect of deletion on DNA damage repair doxorubicin resistance 293T was investigated. Methods Firstly, a pair Oligos targeted designed single guide RNA (sgRNA) expression vectors pSpCas9 (BB)-2A-Puro (PX459) vector. This vector transfected into cells. The effectiveness sgRNA verified by...
Abstract Early detection and intervention are key strategies to reduce mortality, increase long-term survival improve the therapeutic effects of hepatocellular carcinoma (HCC) patients. Herein, isobaric tag for relative absolute quantitation (iTRAQ) quantitative proteomic strategy was used study secretome in conditioned media from HCC cancerous tissues, surrounding noncancerous distal tissues identify diagnostic prognostic biomarkers HCC. In total, 22 49 secretory proteins were identified be...