A5012902167- Nanoplatforms for cancer theranostics
- Photoacoustic and Ultrasonic Imaging
- Gold and Silver Nanoparticles Synthesis and Applications
- Nanoparticle-Based Drug Delivery
- Advanced Nanomaterials in Catalysis
- Advanced biosensing and bioanalysis techniques
- Nanocluster Synthesis and Applications
- Extracellular vesicles in disease
- Luminescence and Fluorescent Materials
- Photodynamic Therapy Research Studies
- Advanced Photocatalysis Techniques
- Sulfur Compounds in Biology
- Molecular Sensors and Ion Detection
- Advancements in Battery Materials
- Quantum Dots Synthesis And Properties
- Metal-Organic Frameworks: Synthesis and Applications
- Lanthanide and Transition Metal Complexes
- Ultrasound and Hyperthermia Applications
- Advanced battery technologies research
- Advanced Battery Materials and Technologies
- Micro and Nano Robotics
- Luminescence Properties of Advanced Materials
- Characterization and Applications of Magnetic Nanoparticles
- 2D Materials and Applications
- Biosensors and Analytical Detection
Beijing University of Chemical Technology
2022-2025
State Key Laboratory of Chemical Engineering
2025
Fuzhou University
2017-2024
Chongqing University
2024
Lanzhou University
2024
Tan Kah Kee Innovation Laboratory
2021-2023
National Institutes of Health
2015-2019
National Institute of Biomedical Imaging and Bioengineering
2015-2019
Dalian University
2018
Dalian University of Technology
2018
Abstract Chemodynamic therapy (CDT) utilizes iron‐initiated Fenton chemistry to destroy tumor cells by converting endogenous H 2 O into the highly toxic hydroxyl radical ( . OH). There is a paucity of Fenton‐like metal‐based CDT agents. Intracellular glutathione (GSH) with OH scavenging ability greatly reduces efficacy. A self‐reinforcing nanoagent based on MnO reported that has both Mn 2+ delivery and GSH depletion properties. In presence HCO 3 − , which abundant in physiological medium,...
Chemodynamic therapy (CDT) employs Fenton catalysts to kill cancer cells by converting intracellular H2O2 into hydroxyl radical (•OH), but endogenous is insufficient achieve satisfactory anticancer efficacy. Despite tremendous efforts, engineering CDT agents with specific and efficient self-supplying ability remains a great challenge. Here, we report the fabrication of copper peroxide (CP) nanodot, which first example Fenton-type metal nanomaterial, its use as an activatable agent for...
We report the development of bioconjugated plasmonic vesicles assembled from SERS-encoded amphiphilic gold nanoparticles for cancer-targeted drug delivery. This new type assemblies with a hollow cavity can play multifunctional roles as delivery carriers anticancer drugs and SERS-active imaging probes to specifically label targeted cancer cells monitor intracellular have shown that pH-responsive disassembly vesicle, stimulated by hydrophobic-to-hydrophilic transition hydrophobic brushes in...
Engineering functional nanomaterials with high therapeutic efficacy and minimum side effects has increasingly become a promising strategy for cancer treatment. Herein, reactive oxygen species (ROS) enhanced combination chemotherapy platform is designed via biocompatible metal-polyphenol networks self-assembly process by encapsulating doxorubicin (DOX) platinum prodrugs in nanoparticles. Both DOX drugs can activate nicotinamide adenine dinucleotide phosphate oxidases, generating superoxide...
Abstract Reactive oxygen species (ROS)‐induced apoptosis is a widely practiced strategy for cancer therapy. Although photodynamic therapy (PDT) takes advantage of the spatial–temporal control ROS generation, meticulous participation light, photosensitizer, and greatly hinders broad application PDT as first‐line treatment option. An activatable system has been developed that enables tumor‐specific singlet ( 1 O 2 ) generation therapy, based on Fenton‐like reaction between linoleic acid...
We report a hybrid reduced graphene oxide (rGO)-loaded ultrasmall plasmonic gold nanorod vesicle (rGO-AuNRVe) (∼65 nm in size) with remarkably amplified photoacoustic (PA) performance and photothermal effects. The also exhibits high loading capacity of doxorubicin (DOX), as both the cavity large surface area encapsulated rGO can be used for DOX, making it an excellent drug carrier. loaded DOX is released sequentially: near-infrared heating induces release from vesicular cavity, intracellular...
Immunogenic cell death (ICD) elicited by photodynamic therapy (PDT) is mediated through generation of reactive oxygen species (ROS) that induce endoplasmic reticulum (ER) stress. However, the half-life ROS very short and intracellular diffusion depth limited, which impairs ER localization thus limits stress induction. To solve problem, we synthesized reduction-sensitive Ds-sP NPs (PEG-s-s-1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[amino(polyethylene glycol)-2000] nanoparticles)...
Sonodynamic therapy (SDT) has the advantages of high penetration, non-invasiveness, and controllability, it is suitable for deep-seated tumors. However, there still a lack effective sonosensitizers with sensitivity, safety, penetration. Now, ultrasound (US) glutathione (GSH) dual responsive vesicles Janus Au-MnO nanoparticles (JNPs) were coated PEG ROS-sensitive polymer. Upon US irradiation, disassembled into small (NPs) promoted penetration ability. Subsequently, GSH-triggered MnO...
A new kind of ultrasmall dissociable AuNR@PEG/PLGA vesicles (≈60 nm) (AuNR = gold nanorod; PEG poly(ethylene glycol); PLGA poly(lactic-co-glycolic acid)) assembled from small AuNRs (dimension: ≈8 nm × 2 is reported. They exhibit several striking features: prolonged circulation and prominent tumor accumulation; rapid excretion the body as AuNR@PEG after therapy; enhanced photoacoustic photo thermal properties; high photothermal cancer therapy efficacy.
The recently emerged exceedingly small magnetic iron oxide nanoparticles (ES-MIONs) (<5 nm) are promising T1-weighted contrast agents for resonance imaging (MRI) due to their good biocompatibility compared with Gd-chelates. However, the best particle size of ES-MIONs T1 is still unknown because synthesis precise control clarify relationship between r1 (or r2/r1) and remains a challenge. In this study, we synthesized seven different sizes below 5 nm found that 3.6 be utilized as MR agent. To...
Gas-involving cancer theranostics have attracted considerable attention in recent years due to their high therapeutic efficacy and biosafety. We reviewed the significant advances development of stimuli-responsive gas releasing molecules (GRMs) nanogenerators for bioimaging, targeted controlled therapy, gas-sensitized synergistic therapy. focused on gases with known anticancer effects, such as oxygen (O2), carbon monoxide (CO), nitric oxide (NO), hydrogen sulfide (H2S), (H2), sulfur dioxide...
We have developed a new class of plasmonic vesicular nanostructures assembled from amphiphilic gold nanocrystals with mixed polymer brush coatings. One major finding is that the integration (nanoparticles and nanorods) two types chemically distinct grafts, which are analogous to block copolymers as whole, creates type hybrid building inheriting amphiphilicity-driven self-assembly form structures properties nanocrystals. In contrast other structures, disruption vesicles can be triggered by...
We report a new type of carbon nanotube ring (CNTR) coated with gold nanoparticles (CNTR@AuNPs) using CNTR as template and surface attached redox-active polymer reducing agent. This nanostructure bundle embedded in the gap closely AuNPs can play multiple roles Raman probe to detect cancer cells photoacoustic (PA) contrast agent for imaging-guided therapy. The CNTR@AuNP exhibits substantially higher optical signals than complete Au shell (CNTR@AuNS) straight CNT@AuNP. extinction intensity is...
Abstract Chemodynamic therapy (CDT) utilizes iron‐initiated Fenton chemistry to destroy tumor cells by converting endogenous H 2 O into the highly toxic hydroxyl radical ( . OH). There is a paucity of Fenton‐like metal‐based CDT agents. Intracellular glutathione (GSH) with OH scavenging ability greatly reduces efficacy. A self‐reinforcing nanoagent based on MnO reported that has both Mn 2+ delivery and GSH depletion properties. In presence HCO 3 − , which abundant in physiological medium,...
Current chemodynamic therapy (CDT) primarily relies on the delivery of transition metal ions with Fenton activity to trigger hydroxyl radical production from hydrogen peroxide. However, administration an excess amount exogenous Fenton-type heavy metals may cause potential adverse effects human health, including acute and chronic damages. Here, we present a new CDT strategy that uses intracellular labile iron pool (LIP) as endogenous source Fenton-reactive for eliciting free generation,...
Recyclable nanocatalysts of core–shell bimetallic nanocrystals are developed through polydopamine coating-directed one-step seeded growth, interfacial assembly, and substrate-immobilization Au@Ag nanocrystals. This strategy provides new opportunities to design optimize heterogeneous with tailored size, morphology, chemical configuration, supporting substrates for metal-catalyzed reactions. As a service our authors readers, this journal information supplied by the authors. Such materials peer...
Abstract The design of bright NIR‐II luminescent nanomaterials that enable efficient labelling proteins without disturbing their physiological properties in vivo is challenging. We developed an strategy to synthesize gold nanoclusters (Au NCs) protected by biocompatible cyclodextrin (CD). Leveraging the ultrasmall size Au NCs (<2 nm) and strong macrocycle‐based host–guest chemistry, as‐synthesized CD‐Au can readily label proteins/antibodies. Moreover, labelled proteins/antibodies highly...
Despite the effort of developing various nanodelivery systems, most them suffer from undesired high uptakes by reticuloendothelial system, such as liver and spleen. Herein we develop an endogenous phosphatase-triggered coassembly strategy to form tumor-specific indocyanine green (ICG)-doped nanofibers (5) for cancer theranostics. Based on coordinated intermolecular interactions, 5 significantly altered near-infrared absorbance ICG, which improves critical photoacoustic photothermal...