A5006379458- Nanoplatforms for cancer theranostics
- Radiopharmaceutical Chemistry and Applications
- Nanoparticle-Based Drug Delivery
- Medical Imaging Techniques and Applications
- Advanced biosensing and bioanalysis techniques
- RNA Interference and Gene Delivery
- Gold and Silver Nanoparticles Synthesis and Applications
- Neuroscience and Neuropharmacology Research
- Photoacoustic and Ultrasonic Imaging
- Peptidase Inhibition and Analysis
- Photodynamic Therapy Research Studies
- Drug Transport and Resistance Mechanisms
- Click Chemistry and Applications
- Advanced MRI Techniques and Applications
- Anesthesia and Neurotoxicity Research
- Adenosine and Purinergic Signaling
- Prostate Cancer Treatment and Research
- Monoclonal and Polyclonal Antibodies Research
- Heme Oxygenase-1 and Carbon Monoxide
- Receptor Mechanisms and Signaling
- Inhalation and Respiratory Drug Delivery
- Chemical Synthesis and Analysis
- Extracellular vesicles in disease
- MicroRNA in disease regulation
- Cell Adhesion Molecules Research
National Institute of Mental Health
2021-2025
National Institutes of Health
2014-2025
Ocean University of China
2021-2024
University of North Carolina at Chapel Hill
2019-2021
Communities In Schools of Orange County
2019-2021
Imaging Center
2019-2020
National Institute of Biomedical Imaging and Bioengineering
2014-2016
Harbin Medical University
2014-2016
Fourth Affiliated Hospital of Harbin Medical University
2014-2016
Multimodal imaging-guided photothermal therapy (PTT), for the of cancer, based on a ferritin (FRT) nanocage loaded with near-infrared dye IR820 (designated DFRT) is demonstrated. The dual roles DFRT (in imaging and PTT) are successfully balanced by using two different excitation wavelengths: 550 nm high quantum-yield fluorescence one hand 808 photoacoustic PTT conversion efficiency other. As service to our authors readers, this journal provides supporting information supplied authors. Such...
A new kind of ultrasmall dissociable AuNR@PEG/PLGA vesicles (≈60 nm) (AuNR = gold nanorod; PEG poly(ethylene glycol); PLGA poly(lactic-co-glycolic acid)) assembled from small AuNRs (dimension: ≈8 nm × 2 is reported. They exhibit several striking features: prolonged circulation and prominent tumor accumulation; rapid excretion the body as AuNR@PEG after therapy; enhanced photoacoustic photo thermal properties; high photothermal cancer therapy efficacy.
We present a novel gold bellflower (GBF) platform with multiple-branched petals, prepared by liquid–liquid–gas triphase interface system, for photoacoustic imaging (PAI)-guided photothermal therapy (PTT). Upon near-infrared (NIR) laser irradiation, the GBFs, strong NIR absorption, showed very PA response and an ultrahigh conversion efficiency (η, ∼74%) among reported agents. The excellent performance in PAI PTT is mainly attributed to unique features of GBFs: (i) petals enhanced local...
Despite the effort of developing various nanodelivery systems, most them suffer from undesired high uptakes by reticuloendothelial system, such as liver and spleen. Herein we develop an endogenous phosphatase-triggered coassembly strategy to form tumor-specific indocyanine green (ICG)-doped nanofibers (5) for cancer theranostics. Based on coordinated intermolecular interactions, 5 significantly altered near-infrared absorbance ICG, which improves critical photoacoustic photothermal...
Pyroptosis, systemic inflammation, and mitochondrial apoptosis are the three primary contributors to sepsis's multiple organ failure, ultimate cause of high clinical mortality. Currently, drugs under development only target a single pathogenesis, which is obviously insufficient. In this study, an acid-responsive hollow mesoporous polydopamine (HMPDA) nanocarrier that highly capable carrying both hydrophilic drug NAD
Severe acute pancreatitis (AP) is a life-threatening pancreatic inflammatory disease with high mortality rate (∼40%). Existing pharmaceutical therapies in development or clinical trials showed insufficient treatment efficacy due to their single molecular therapeutic target, poor water solubility, short half-life, limited pancreas-targeting specificity, etc. Herein, acid-responsive hollow mesoporous Prussian blue nanoparticles wrapped neutrophil membranes and surface modified the...
Using positron emission tomography (PET) imaging to monitor and quantitatively analyze the delivery localization of Au nanomaterials (NMs), a widely used photothermal agent, is essential optimize therapeutic protocols achieve individualized medicine avoid side effects. Coupling radiometals NMs via chelator faces challenges possible detachment as well surface property changes NMs. In this study, we reported simple general chelator-free 64Cu radiolabeling method by chemically reducing on...
Functionalized quantum dots (QDs) have been widely explored for multimodality bioimaging and proven to be versatile agents. Attaching positron-emitting radioisotopes onto QDs not only endows their positron emission tomography (PET) functionality, but also results in self-illuminating QDs, with no need an external light source, by Cerenkov resonance energy transfer (CRET). Traditional chelation methods used incorporate the radionuclide, these are compromised potential loss of radionuclide due...
Minimizing the sequestration of nanomaterials (NMs) by reticuloendothelial system (RES) can enhance circulation time NMs, and thus increase their tumor-specific accumulation. Liposomes are generally regarded as safe (GRAS) agents that block RES reversibly temporarily. With help positron emission tomography (PET), we monitored in vivo tissue distribution 64Cu-labeled 40 × 10 nm gold nanorods (Au NRs) after pretreatment with liposomes. We systematically studied effectiveness liposome...
Phototherapies such as photodynamic therapy (PDT) and photothermal (PTT), due to their specific spatiotemporal selectivity minimal invasiveness, have been widely investigated alternative treatments of malignant diseases. Graphene its derivatives not only used carriers deliver photosensitizers for PDT, but also conversion agents (PTCAs) PTT. Herein, we strategically designed produced a novel photo-theranostic platform based on sinoporphyrin sodium (DVDMS) photosensitizer-loaded PEGylated...
Conventional evaluation methods of chemotherapeutic efficacy such as tissue biopsy and anatomical measurement are either invasive with potential complications or dilatory to capture the rapid pathological changes. Here, a sensitive resolution-scalable photoacoustic microscopy (PAM) theranostic nanoformulation was developed noninvasively monitor therapy response in timely manner. Ultrasmall graphene oxide nanosheets were designed both drug-loading vehicle signal amplifier tumor. With...
This study aimed to document the first-in-human application of a 68Ga-labeled heterodimeric peptide BBN-RGD (bombesin-RGD) that targets both integrin αvβ3 and gastrin-releasing receptor (GRPR). We evaluated safety assessed clinical diagnostic value 68Ga-BBN-RGD PET/CT in prostate cancer patients comparison with 68Ga-BBN.Five healthy volunteers (4 men 1 woman; age range, 28-53 y) were enrolled validate 68Ga-BBN-RGD. Dosimetry was calculated using OLINDA/EXM software. Thirteen newly diagnosed...
Tenascin-C is an extracellular matrix glycoprotein that expressed by injured tissues and various cancers. Recent publications showed tenascin-C expression cancer lesions predicts tumor growth, metastasis, angiogenesis, suggesting as a potential therapeutic target. Currently there no noninvasive method to determine tumoral in vivo. To address the need for agent image quantify tenascin-C, we report development of radioactive PET tracer based on tenascin-C–specific single-stranded DNA aptamer...
A series of polymer micelles with a perfluorocarbon (PFC) core to carry both PS and O<sub>2</sub> tumor sites was prepared. These new PFC formulation not only improved the production <sup>1</sup>O<sub>2</sub> enhanced PDT efficiency, but also significantly reduced cell toxicity compared one without perfluoro unit.
Calcium overload is one of the early determinants core cellular events that contribute to pathogenesis acute kidney injury (AKI), which include oxidative stress, ATP depletion, calcium overload, and inflammatory response with self-amplifying interactive feedback loops ultimately lead renal failure. Excluding adjuvant therapy, there are currently no approved pharmacotherapies for treatment AKI. Using an adipic dihydride linker, we modified hyaluronic acid polymer chain a potent antioxidant,...
Abstract RNA interference (RNAi) is an RNA‐dependent gene silencing approach controlled by RNA‐induced complex (RISC). Herein, we present a synthetic RISC‐mimic nanocomplex, which can actively cleave its target in sequence‐specific manner. With high enzymatic stability and efficient self‐delivery to cells, the designed nanocomplex selectively potently induce without cytokine activation. These nanocomplexes, multidrug resistance, are not only able bypass P‐glycoprotein (Pgp) transporter, due...
Receptor interacting protein kinase 1 (RIPK1) crucially upregulates necroptosis and is a key driver of inflammation. An effective PET radioligand for imaging brain RIPK1 would be useful further exploring the role this enzyme in neuroinflammation assisting drug discovery. Here, we report our progress on developing based phenyl-1
Molecular imaging (MI) can provide not only structural images using traditional techniques but also functional and molecular information many newly emerging techniques. Over the past decade, utilization of nanotechnology in MI has exhibited significant advantages provided new opportunities for living subjects. It is expected that multimodality nanoparticles (NPs) lead to precise assessment tumor biology microenvironment. This review addresses topics related engineered NPs summarizes recent...