A5012690244- Nanoplatforms for cancer theranostics
- Nanoparticle-Based Drug Delivery
- RNA Interference and Gene Delivery
- Environmental Toxicology and Ecotoxicology
- Advanced biosensing and bioanalysis techniques
- Advanced Nanomaterials in Catalysis
- Immunotherapy and Immune Responses
- Immune cells in cancer
- Photodynamic Therapy Research Studies
- Virus-based gene therapy research
- Mercury impact and mitigation studies
- Cancer Immunotherapy and Biomarkers
- Heavy Metal Exposure and Toxicity
- Graphene and Nanomaterials Applications
- Hydrogels: synthesis, properties, applications
- Dendrimers and Hyperbranched Polymers
- Drug Transport and Resistance Mechanisms
- Amphibian and Reptile Biology
- Phagocytosis and Immune Regulation
- Pharmaceutical and Antibiotic Environmental Impacts
- Polymer Surface Interaction Studies
- Advanced Drug Delivery Systems
- Advanced Polymer Synthesis and Characterization
- Supramolecular Self-Assembly in Materials
- Immune Cell Function and Interaction
Xidian University
2021-2024
Tianjin University
2013-2023
State Key Laboratory of Chemobiosensing and Chemometrics
2023
National University of Singapore
2021-2023
Chang'an University
2011-2023
Hunan University
2023
Chinese Academy of Sciences
2017-2022
Microbiology Institute of Shaanxi
2022
Institute of Microbiology
2022
National Institute of Biomedical Imaging and Bioengineering
2019-2021
Chemodynamic therapy (CDT) employs Fenton catalysts to kill cancer cells by converting intracellular H2O2 into hydroxyl radical (•OH), but endogenous is insufficient achieve satisfactory anticancer efficacy. Despite tremendous efforts, engineering CDT agents with specific and efficient self-supplying ability remains a great challenge. Here, we report the fabrication of copper peroxide (CP) nanodot, which first example Fenton-type metal nanomaterial, its use as an activatable agent for...
Immunogenic cell death (ICD) elicited by photodynamic therapy (PDT) is mediated through generation of reactive oxygen species (ROS) that induce endoplasmic reticulum (ER) stress. However, the half-life ROS very short and intracellular diffusion depth limited, which impairs ER localization thus limits stress induction. To solve problem, we synthesized reduction-sensitive Ds-sP NPs (PEG-s-s-1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[amino(polyethylene glycol)-2000] nanoparticles)...
Article10 October 2019Open Access Source Data Lipid droplet-dependent fatty acid metabolism controls the immune suppressive phenotype of tumor-associated macrophages Hao Wu The First Affiliated Hospital, Zhengzhou University, Zhengzhou, China Medical Department for Gastroenterology, Infectious Diseases and Rheumatology, Charité - Universitätsmedizin Berlin, corporate member Freie Universität Humboldt-Universität zu Berlin Institute Health, Germany Biology, Chemistry, Pharmacy, Search more...
Combination therapy that could better balance immune activation and suppressive signals holds great potential in cancer immunotherapy. Herein, we serendipitously found the pH-responsive nanovesicles (pRNVs) self-assembled from block copolymer polyethylene glycol-b-cationic polypeptide can not only serve as a nanocarrier but also cause immunogenic cell death (ICD) through preapoptotic exposure of calreticulin. After coencapsulation photosensitizer, 2-(1-hexyloxyethyl)-2-devinyl...
Abstract Tumor‐lymph node (LN) metastasis is the dominant prognostic factor for tumor staging and therapeutic decision‐making. However, concurrently visualizing performing imaging‐guided lymph surgery challenging. Here, a multiplexed‐near‐infrared‐II (NIR‐II) in vivo imaging system using nonoverlapping NIR‐II probes with markedly suppressed photon scattering zero‐autofluorescence reported, which enables visualization of metastatic proximal LNs resection. A bright tumor‐seeking...
Current chemodynamic therapy (CDT) primarily relies on the delivery of transition metal ions with Fenton activity to trigger hydroxyl radical production from hydrogen peroxide. However, administration an excess amount exogenous Fenton-type heavy metals may cause potential adverse effects human health, including acute and chronic damages. Here, we present a new CDT strategy that uses intracellular labile iron pool (LIP) as endogenous source Fenton-reactive for eliciting free generation,...
Abstract Immunogenic cell death (ICD) and tumour-infiltrating T lymphocytes are severely weakened by elevated reactive oxygen species (ROS) in the tumour microenvironment. It is therefore of critical importance to modulate level extracellular ROS for reversal immunosuppressive environment. Here, we present a matrix (ECM) targeting nanoscavenger masked pH sensitive covalently crosslinked polyethylene glycol. The anchors on ECM sweep away from microenvironment relieve ICD elicited specific...
Abstract Cell membrane coating nanotechnology, which endows nanoparticles with unique properties, displays excellent translational potential in cancer diagnosis and therapy. However, the preparation evaluation of these cell membrane‐coated are based on lines cell‐line‐based xenograft mouse models. The feasibility membrane‐camouflaged nanomaterials is tested a preclinical setting. Head neck squamous carcinoma (HNSCC) patient‐derived tumor (PDTC) membranes coated onto gelatin (GNPs) resulting...
ConspectusCancer vaccines have shown tremendous potential in preventing and treating cancer by providing immunogenic antigens to initiate specific tumor immune responses. An situ vaccine prepared from an autologous can mobilize a patient's own cell lysate as reservoir of antigens, thus triggering broad response diverse antitumor immunity individually tailored manner. Its efficacy is much better than that conventional with limited number epitopes. Several therapies, including radiotherapy...
The application of PEG-b-PCL micelles was dampened by their inherent low drug-loading capability and relatively poor cell uptake efficiency. In this study, a series novel copolymers methoxy poly(ethylene glycol)-b-poly(ε-caprolactone-co-γ-dimethyl maleamidic acid -ε-caprolactone) (mPEG-b-P(CL-co-DCL)) bearing different amounts acid-labile β-carboxylic amides on the polyester moiety were synthesized. chain structure chemical composition characterized (1)H NMR, Fourier transform infrared...
Abstract Nanomedicines with photodynamic therapy and reactive oxygen species (ROS)‐triggered drug release capabilities are promising for cancer therapy. However, most of the nanomedicines based on ROS‐responsive nanocarriers still suffer from serious ROS consumption during triggered process. Herein, a photodynamic‐chemodynamic cascade strategy design delivery nanosystem is proposed. A doxorubicin hydrochloride‐loaded polymersome (DOX‐RPS) prepared via self‐assembly amphiphilic poly(ethylene...
Abstract Chemical transformation in cellular environment is critical for regulating biological processes and metabolic pathways. Harnessing biocatalytic cascades to produce chemicals of interest has become a research focus benefit industrial pharmaceutic areas. Nanoreactors, which can act as artificial cell‐like devices organize cascade reactions, have been recently proposed potential therapeutic applications life‐threatening illnesses. Among various types nanomaterials, there growing 2D...
Abstract Immunological tolerance induced by the hypoxic tumor microenvironment has been a major challenge for current immune checkpoint blockade therapies. Here, hypoxia‐responsive drug delivery nanoplatform is reported to promote chemoimmunotherapy of cancer overcoming hypoxia‐induced immunological tumors. The nanovesicles are assembled from manganese ferrite nanoparticles (MFNs) grafted with amphiphilic polymers as membrane, doxorubicin hydrochloride (Dox) loaded in aqueous cavities. Under...
Abstract Tumor heterogeneity is one major reason for unpredictable therapeutic outcomes, while stratifying responses at an early time may greatly benefit the better control of cancer. Here, we developed a hybrid nanovesicle to stratify radiotherapy response by activatable inflammation magnetic resonance imaging (aiMRI) approach. The high Pearson’s correlation coefficient R values are obtained from correlations between T 1 relaxation changes 24–48 h and ensuing adaptive immunity ( = 0.9831)...
Among the few available mRNA delivery vehicles, lipid nanoparticles (LNPs) are most clinically advanced but they require cumbersome four components and suffer from inflammation-related side effects that should be minimized for safety. Yet, a certain level of proinflammatory responses innate immune activation required to evoke T-cell immunity cancer vaccination. To address these issues develop potent yet low-inflammatory vaccine vectors, series alternating copolymers "PHTA" featured with...