A5046426748- Nanoplatforms for cancer theranostics
- Advanced Nanomaterials in Catalysis
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Luminescence and Fluorescent Materials
- Photodynamic Therapy Research Studies
- Microbial Natural Products and Biosynthesis
- Gold and Silver Nanoparticles Synthesis and Applications
- Dendrimers and Hyperbranched Polymers
- Advanced biosensing and bioanalysis techniques
- Carbon Nanotubes in Composites
- Cancer Treatment and Pharmacology
- Fungal Biology and Applications
- Metal-Organic Frameworks: Synthesis and Applications
- Conducting polymers and applications
- Nanocluster Synthesis and Applications
- Marine Sponges and Natural Products
- Natural product bioactivities and synthesis
- Nanoparticle-Based Drug Delivery
- Immunotherapy and Immune Responses
- Advanced Polymer Synthesis and Characterization
- Synthetic Organic Chemistry Methods
- Advanced Sensor and Energy Harvesting Materials
- Quantum Dots Synthesis And Properties
- Laser-Ablation Synthesis of Nanoparticles
Hangzhou Normal University
2022-2025
National University of Singapore
2021-2024
Xiyuan Hospital
2021-2024
Agency for Science, Technology and Research
2023-2024
Institute of Molecular and Cell Biology
2023-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2010-2024
Chongqing Three Gorges University
2024
Affiliated Hospital of Hangzhou Normal University
2022-2023
Macau University of Science and Technology
2022-2023
Nanjing Tech University
2017-2022
A one-step homogeneous immunoassay for the detection of a prostate cancer biomarker, free-PSA (prostate specific antigen), was developed using gold nanoparticle probes coupled with dynamic light scattering (DLS) measurements. spherical core diameter around 37 nm and nanorod dimension 40 by 10 were first conjugated two different primary anti-PSA antibodies then used as optical immunoassay. In presence antigen f-PSA in solution, nanoparticles nanorods aggregate together into pairs oligomers...
Ti3C2 MXene is a new two-dimensional material exhibiting variety of novel properties including good photothermal effect, and the capability for multimodal tumor therapy in urgent need development. Herein, ultrathin nanosheets (∼100 nm) have been synthesized by supplying additive Al3+ to avoid Al loss employed as photothermal/photodynamic agent cancer therapy. The as-obtained exhibit outstanding mass extinction coefficient (28.6 Lg–1 cm–1 at 808 nm), superior conversion efficiency (∼58.3%),...
Ultralight multiwalled carbon nanotube (MWCNT) aerogel is fabricated from a wet gel of well-dispersed pristine MWCNTs. On the basis theoretical prediction that increasing interaction potential between CNTs lowers their critical concentration to form an infinite percolation network, poly(3-(trimethoxysilyl) propyl methacrylate) (PTMSPMA) used disperse and functionalize MWCNTs where subsequent hydrolysis condensation PTMSPMA introduces strong permanent chemical bonding The both experimentally...
Biocatalytic reactions in living cells involve complex transformations the spatially confined microenvironments. Inspired by biological transformation processes, we demonstrate effective biocatalytic cascade driven photodynamic therapy tumor-bearing mice integration of an artificial enzyme (ultrasmall Au nanoparticles) with upconversion nanoparticles (NaYF4@NaYb0.92F4:Er0.08@NaYF4)zirconium/iron porphyrin metal-organic framework core-shell (UMOF NPs) which act as biocatalysts and...
Heavy atom effect and configuration are important for BODIPY derivatives to generate singlet oxygen (1O2) photodynamic therapy. Herein, a series of with different halogens were synthesized. 1O2 quantum yields (QYs) MTT assay confirm that incorporation more heavy atoms onto dimeric cannot effectively enhance the QYs. Rather, dark toxicity increases. This phenomenon can be attributed competition BODIPY. In addition derivative two iodine (BDPI) owns highest QYs (73%) lowest phototoxicity IC50...
In preclinical and clinical research, to destroy cancers, particularly those located in deep tissues, is still a great challenge. Photodynamic therapy photothermal are promising alternative approaches for tissue cancer curing. Black phosphorus (BP)-based nanomaterials, with broad UV-vis near-infrared absorbance excellent effect, have shown potential biomedical applications. Herein, biocompatible therapeutic platform, chlorin e6 (Ce6)-decorated BP nanosheets (NSs), has been developed...
The combination of reactive oxygen species (ROS)-involved photodynamic therapy (PDT) and chemodynamic (CDT) holds great promise for enhancing ROS-mediated cancer treatment. Herein, we reported an in situ polymerized hollow mesoporous organosilica nanoparticle (HMON) biocatalysis nanoreactor to integrate the synergistic effect PDT/CDT pancreatic ductal adenocarcinoma HPPH photosensitizer was hybridized within framework HMON via "in growth" approach. Then, cavity HMONs exploited as a...
Continuous irradiation during photodynamic therapy (PDT) inevitably induces tumor hypoxia, thereby weakening the PDT effect. In PDT-induced providing singlet oxygen from stored chemical energy may enhance cell-killing effect and boost therapeutic Herein, we present a phototheranostic (DPPTPE@PEG-Py NPs) prepared by using 2-pyridone-based diblock polymer (PEG-Py) to encapsulate semiconducting, heavy-atom-free pyrrolopyrrolidone-tetraphenylethylene (DPPTPE) with high singlet-oxygen-generation...
Abstract Improving singlet oxygen ( 1 O 2 ) lifespan by fractionated delivery in dark and hypoxic conditions is a better way to achieve enhanced phototherapeutic efficacy. Herein, three boron dipyrromethene (BODIPY) dyes are synthesized demonstrate that anthracence‐functionalized BODIPY, namely ABDPTPA an efficient heavy‐atom‐free photosensitizer for the reversible capture release of . The spin–orbit charge‐transfer intersystem crossing promises high quantum yield 60% dichloromethane. Under...
The clinical employment of cisplatin (cis-diamminedichloroplatinum(II) (CDDP)) is largely constrained due to the non-specific delivery and resultant serious systemic toxicity. Small-sized biocompatible biodegradable hollow mesoporous organosilica (HMOS) nanoparticles show superior advantages for targeted CDDP but suffer from premature leakage. Herein, smart use a bimetallic Zn2+ /Cu2+ co-doped metal-organic framework (MOF) made block pores HMOS preventing potential leakage remarkably...
Abstract The outcome of radiotherapy is significantly restricted by tumor hypoxia. To overcome this obstacle, one prevalent solution to increase intratumoral oxygen supply. However, its effectiveness often limited the high metabolic demand for O 2 cancer cells. Herein, we develop a hybrid semiconducting organosilica-based nanoeconomizer pHPFON-NO/O combat Our twofold: first, interacts with acidic microenvironment release NO endogenous conservation; second, it releases in response mild...
Fenton reaction-based chemodynamic therapy (CDT), which applies metal ions to convert less active hydrogen peroxide (H2O2) into more harmful hydroxyl (·OH) for tumor treatment, has attracted increasing interest recently. However, the CDT is substantially hindered by glutathione (GSH) scavenging effect on ·OH, low intracellular H2O2 level, and reaction rate, resulting in unsatisfactory efficacy. Here, a cancer cell membrane (CM)-camouflaged Au nanorod core/mesoporous MnO2 shell yolk–shell...
As a rising generation of nanozymes, single atom enzymes show significant promise for cancer therapy, due to their maximum utilization efficiency and well-defined electronic structures. However, it remains tremendous challenge precisely produce heteroatom-doped enzyme with an expected coordination environment. Herein, we develop anion exchange strategy controlled production edge-rich sulfur (S)- nitrogen (N)-decorated nickel (S-N/Ni PSAE). In particular, sulfurized S-N/Ni PSAE exhibits...
Therapeutic interventions of hepatic ischemia-reperfusion injury to attenuate liver dysfunction or multiple organ failure following surgery and transplantation remain limited. Here we present an innovative strategy by integrating a platinum nanoantioxidant inducible nitric oxide synthase into the zeolitic imidazolate framework-8 based hybrid nanoreactor for effective prevention injury. We show that can scavenge excessive reactive oxygen species at site meanwhile generate subsequent synthesis...
Nanocatalysts are promising tumor therapeutics due to their ability induce reactive oxygen species in the microenvironment. Although increasing metal loading can improve catalytic activity, quandary of high content versus potential systemic biotoxicity remains challenging. Here, a fully exposed active site strategy by site-specific anchoring single iridium (Ir) atoms on outer surface nitrogen-doped carbon composite (Ir single-atom catalyst (SAC)) is reported achieve remarkable performance at...
Abstract The metabolic reprogramming of tumors requires high levels adenosine triphosphate (ATP) to maintain therapeutic resistance, posing a major challenge for photothermal therapy (PTT). Although raising the temperature helps in tumor ablation, it frequently leads severe side effects. Therefore, improving response and promoting healing are critical considerations development PTT. Here, we proposed gas‐mediated energy remodeling strategy improve mild PTT efficacy while minimizing In...
Abstract Cuproptosis is a newly discovered form of programmed cell death significantly depending on the transport efficacy copper (Cu) ionophores. However, existing Cu ionophores, primarily small molecules with short blood half‐life, face challenges in transporting enough amounts ions into tumor cells. This work describes construction carrier‐free nanoparticles (Ce6@Cu NPs), which self‐assembled by coordination 2+ sonosensitizer chlorin e6 (Ce6), facilitating sonodynamic‐triggered...
Tumor hypoxia diminishes the effectiveness of traditional type II photodynamic therapy (PDT) due to oxygen consumption. Type I PDT, which can operate independently oxygen, is a viable option for treating hypoxic tumors. In this study, we have designed and synthesized JSK@PEG-IR820 NPs that are responsive tumor microenvironment (TME) enhance PDT through glutathione (GSH) depletion. Our approach aims expand sources therapeutic benefits by promoting generation superoxide radicals (O
Enzymes are considered safe and effective therapeutic tools for various diseases. With the increasing integration of biomedicine nanotechnology, artificial nanozymes offer advanced controllability functionality in medical design. However, several notable gaps, such as catalytic diversity, specificity biosafety, still exist between their native counterparts. Here we report a non-metal single-selenium (Se)-atom nanozyme (SeSAE), which exhibits potent nicotinamide adenine dinucleotide phosphate...
A complete dispersion of both single-wall and multiwall carbon nanotubes (CNTs) to individual tube level was achieved using a conjugated block copolymer without chemical modification the pristine CNTs. The contains two structural segments, poly(3-hexylthiophene) (P3HT) segment polystyrene (PS) segment. P3HT forms π–π interactions with CNTs, while provides good solubility de-bundled nanotubes. This approach is generic for nanotube dispersion. Supporting information this article available on...