A5100377335- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Advanced biosensing and bioanalysis techniques
- RNA and protein synthesis mechanisms
- Gold and Silver Nanoparticles Synthesis and Applications
- Phytochemistry and biological activity of medicinal plants
- Biosensors and Analytical Detection
- Nanoparticle-Based Drug Delivery
- Magnetic and transport properties of perovskites and related materials
- Heat transfer and supercritical fluids
- Metal-Organic Frameworks: Synthesis and Applications
- Lipid Membrane Structure and Behavior
- Organic and Molecular Conductors Research
- Nanoplatforms for cancer theranostics
- Cellular Mechanics and Interactions
- Advanced Condensed Matter Physics
- Genomics and Phylogenetic Studies
- Protein Structure and Dynamics
- Bone Tissue Engineering Materials
- Force Microscopy Techniques and Applications
- RNA modifications and cancer
- Electrochemical sensors and biosensors
- Luminescence and Fluorescent Materials
- Phase Equilibria and Thermodynamics
- Chromosomal and Genetic Variations
Chinese Academy of Sciences
2016-2025
University of Science and Technology of China
2016-2025
Hefei Institutes of Physical Science
2016-2025
High Magnetic Field Laboratory
2016-2025
Huazhong University of Science and Technology
2016-2025
Wuhan National Laboratory for Optoelectronics
2025
Anhui University
2014-2024
Anhui Medical University
2022-2024
Jiangsu University
2023-2024
Hainan University
2021-2024
Chemodynamic therapy (CDT) employs Fenton catalysts to kill cancer cells by converting intracellular H2O2 into hydroxyl radical (•OH), but endogenous is insufficient achieve satisfactory anticancer efficacy. Despite tremendous efforts, engineering CDT agents with specific and efficient self-supplying ability remains a great challenge. Here, we report the fabrication of copper peroxide (CP) nanodot, which first example Fenton-type metal nanomaterial, its use as an activatable agent for...
Magnetic resonance is essential in revealing the structure and dynamics of biomolecules. However, measuring magnetic spectrum single biomolecules has remained an elusive goal. We demonstrate detection electron spin signal from a spin-labeled protein under ambient conditions. As sensor, we use nitrogen vacancy center bulk diamond close proximity to protein. measure orientation label at detect impact motion on dynamics. In addition, coherently drive protein, which prerequisite for studies...
Abstract Quantum spin liquid (QSL) is a novel state of matter which refuses the conventional freezing even at 0 K. Experimentally searching for structurally perfect candidates big challenge in condensed physics. Here we report successful synthesis new spin-1/2 triangular antiferromagnet YbMgGaO 4 with "Equation missing"<!-- image only, no MathML or LaTex --> sy m metry. The compound an ideal two-dimensional and spatial isotropic magnetic triangular-lattice has site-mixing defects...
This study proposes a facile method for synthesis of Au-coated magnetic nanoparticles (AuMNPs) core/shell nanocomposites with nanoscale rough surfaces. MnFe2O4 (NPs) were first modified uniform polyethylenimine layer (2 nm) through self-assembly under sonication. The negatively charged Au seeds then adsorbed on the surface NPs electrostatic interaction shell formation. Our newly developed sonochemically assisted hydroxylamine seeding growth was used to grow gold into large (AuNPs) form...
Systemic delivery of mRNA-based therapeutics remains a challenging issue for preclinical and clinical studies. Here, we describe new lipid-like nanoparticles (TT-LLNs) developed through an orthogonal array design, which demonstrates improved efficiency mRNA encoding luciferase in vitro by over 350-fold with significantly reduced experimental workload. One optimized TT3 LLN, termed O-TT3 LLNs, was able to restore the human factor IX (hFIX) level normal physiological values FIX-knockout mice....
SIRT1, the founding member of mammalian family seven NAD(+)-dependent sirtuins, is composed 747 amino acids forming a catalytic domain and extended N- C-terminal regions. We report design characterization an engineered human SIRT1 construct (mini-hSIRT1) containing minimal structural elements required for lysine deacetylation activation by small molecule sirtuin-activating compounds (STACs). Using this construct, we solved crystal structure mini-hSIRT1-STAC complex, which revealed...
A magnetically assisted surface-enhanced Raman scattering (SERS) biosensor for single-cell detection of S. aureus on the basis aptamer recognition is reported first time. The consists two basic elements including a SERS substrate (Ag-coated magnetic nanoparticles, AgMNPs) and novel tag (AuNR–DTNB@Ag–DTNB core–shell plasmonic NPs or DTNB-labeled inside-and-outside NPs, DioPNPs). Uniform, monodisperse, superparamagnetic AgMNPs with favorable activity responsiveness are synthesized by using...
A rapid, sensitive, and label-free SERS detection method for bacteria pathogens is reported the first time. The method, which based on combination of polyethylenimine (PEI)-modified Au-coated magnetic microspheres (Fe3O4@Au@PEI) concentrated Au@Ag nanoparticles (NPs), was named capture-enrichment-enhancement (CEE) three-step method. novel Fe3O4@Au microsphere with monodispersity strong responsiveness synthesized as a substrate amino functionalized by PEI self-assembly. negatively charged...
Abstract Citrate is essential to biomineralization of the bone especially as an integral part apatite nanocomposite. precipitate hypothesized be derived from mesenchymal stem/stromal cells (MSCs) upon differentiation into mature osteoblasts. Based on 13 C‐labeled signals identified by solid‐state multinuclear magnetic resonance analysis, boosted mitochondrial activity and carbon‐source replenishment tricarboxylic acid cycle intermediates coordinate feed forward anabolism deposition citrate....
Two hallmarks for cancer cells are the accelerated cell cycle progression as well altered metabolism, however, how these changes coordinated to optimize growth advantage still poorly understood. Here we identify that Polo-like kinase 1 (Plk1), a key regulator mitosis, plays critical role biosynthesis in through activating pentose phosphate pathway (PPP). We find Plk1 interacts with and directly phosphorylates glucose-6-phosphate dehydrogenase (G6PD). By G6PD promoting formation of its active...
Abstract Background Long non-coding RNAs (lncRNAs) are tumor-associated biological molecules and have been found to be implicated in the progression of colorectal cancer (CRC). This study aims examine effects lncRNA RP11-468E2.5 its target genes (STAT5 STAT6) on activities CRC cells via Janus kinase-signal transducer activator transcription (JAK/STAT) signaling pathway. Methods We initially screened GEO database for differentially expressed lncRNAs related then made a prediction genes. Then...
Cancers arise from successive rounds of mutation and selection, generating clonal populations that vary in size, mutational content drug responsiveness. Ascertaining the composition a tumor is therefore important both for prognosis therapy. Mutation counts frequencies resulting next-generation sequencing (NGS) potentially reflect tumor's composition; however, deconvolving NGS data to infer structure presents major challenge. We propose generative model derived multiple subsections single...
Compared to 1H MRI, 19F MRI provides higher selectivity but lower sensitivity. Therefore, the need inject high doses of probe improve its sensitivity for in vivo diagnosis remains a challenge. A "smart" strategy is needed that could locally concentrate low-dose while avoiding fast transverse relaxation probes. Locally self-assembling and disassembling nanoparticles may be an optimal measure achieve this goal. Herein, we report dual-functional 1 glutathione (GSH)-controlled self-assembly...
Our previous studies demonstrated that the natural compound emodin blocks tumor-promoting feedforward interactions between cancer cells and macrophages, thus ameliorates immunosuppressive state of tumor microenvironment. Since tumor-associated macrophages (TAMs) also affect epithelial mesenchymal-transition (EMT) stem cell (CSC) formation, here we aimed to test if as a neoadjuvant therapy halts breast metastasis by attenuating TAM-induced EMT CSC formation cells. Methods: Bioinformatical...
19F MRI has higher selectivity but lower sensitivity than 1H for in vivo diagnosis. Therefore, to avoid using a high injection dose of the probe while, meantime, maintaining remained challenging. Local self-assembly and disassembly nanoparticles could be one “smart” strategies achieve this goal. Herein, we report dual-functional 1 glutathione (GSH)-controlled subsequent legumain (Lgmn)-controlled its (i.e., 1-NPs). Self-assembly 1-NPs confer magnetic resonance (MR) signals “off” “on”,...