A5101962419- Cancer, Hypoxia, and Metabolism
- Acute Myeloid Leukemia Research
- Plant Stress Responses and Tolerance
- Cytokine Signaling Pathways and Interactions
- Natural product bioactivities and synthesis
- Head and Neck Cancer Studies
- MicroRNA in disease regulation
- Alcohol Consumption and Health Effects
- Liver Disease Diagnosis and Treatment
- Physical Activity and Health
- Ubiquitin and proteasome pathways
- CRISPR and Genetic Engineering
- Esophageal Cancer Research and Treatment
- Obesity, Physical Activity, Diet
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Acute Lymphoblastic Leukemia research
- Machine Learning in Bioinformatics
- Nutritional Studies and Diet
- Pancreatic function and diabetes
- Protein Structure and Dynamics
- Epigenetics and DNA Methylation
- Wheat and Barley Genetics and Pathology
- NF-κB Signaling Pathways
- Animal Genetics and Reproduction
Tongji Hospital
2018-2025
Huazhong University of Science and Technology
2015-2025
Peking University
2010-2025
Peking University Third Hospital
2025
Zhongda Hospital Southeast University
2021-2024
Yangzhou University
2018-2024
Fujian Medical University
2023-2024
Yan'an University
2024
Yanan University Affiliated Hospital
2024
Wuhan University of Science and Technology
2007-2024
Two hallmarks for cancer cells are the accelerated cell cycle progression as well altered metabolism, however, how these changes coordinated to optimize growth advantage still poorly understood. Here we identify that Polo-like kinase 1 (Plk1), a key regulator mitosis, plays critical role biosynthesis in through activating pentose phosphate pathway (PPP). We find Plk1 interacts with and directly phosphorylates glucose-6-phosphate dehydrogenase (G6PD). By G6PD promoting formation of its active...
Calcineurin B-like (CBL) proteins belong to a unique group of calcium sensors in plant that decode the Ca2+ signature by interacting with CBL-interacting protein kinases (CIPKs). Although CBL-CIPK complexes have been shown play important roles responses various stresses plants, little is known about their functions wheat. A total seven TaCBL and 20 TaCIPK genes were amplified from bread wheat, Triticum aestivum cv. Chinese Spring. Reverse-transcriptase-polymerase chain reaction (RT-PCR)...
Background: hTERT gene plays an important role in melanoma, although the specific mechanism involved is unclear. The aim of this study was to screen and identify relative miRNAs with regulation melanoma. Materials methods: Quantitative real-time polymerase chain reaction (q-PCR) immunohistochemistry were performed detect mRNA protein expression 36 formalin-fixed paraffin-embedded melanoma tissues age- sex-matched pigmented nevi cases, respectively. Bioinformatics analysis custom miRNA array...
Protein lysine acetylation plays an important role in the normal functioning of cells, including gene expression regulation, protein stability and metabolism regulation. Although large amounts sites have been identified via large-scale mass spectrometry or traditional experimental methods, (K)-acetyl-transferase (KAT) responsible for a given site remains largely unknown due to limitations KAT substrate identification. Hence, silico prediction KAT-specific may provide direction further...
In plants, the CBL-CIPK signaling pathways play key roles in response to abiotic stresses. However, functional studies of CIPKs important staple crop wheat are very rare. this study, we identified a CIPK gene from wheat, designated TaCIPK2. Expression analysis results showed that TaCIPK2 could be up-regulated leaves by polyethylene glycol, abscisic acid and H2O2 treatments. Subcellular localization analyses revealed was present whole epidermal cells. A yeast two-hybrid assay indicated...
Abstract Pathogen detection from biological and environmental samples is important for global disease control. Despite advances in pathogen using deep learning, current algorithms have limitations processing long genomic sequences. Through the cross-fusion of cross, residual neural networks, we developed DCiPatho accurate based on integrated frequency features 3-to-7 k-mers. Compared with existing state-of-the-art algorithms, can be used to accurately identify distinct pathogenic bacteria...
Introduction It has been reported that individuals with type 1 diabetes (T1D) are at a higher risk of concomitant occurrence other autoimmune diseases (AIDs). Currently, there is lack research investigating the causal relationship between T1D and AIDs. A comprehensive Mendelian randomization (MR) study was conducted using debiased inverse-variance weighted (dIVW) (IVW) estimators to examine bidirectional 12 Material methods Genome-wide association (GWAS) summary statistics datasets related...
Phosphorylation is an important type of protein post-translational modification. Identification possible phosphorylation sites a for understanding its functions. Unbiased screening by in vitro or vivo experiments time consuming and expensive; silico prediction can provide functional candidates help narrow down the experimental efforts. Most existing algorithms take only polypeptide sequence around into consideration. However, very complex biological process vivo. The sequences potential are...
Avenin-like b proteins are a small family of wheat storage proteins, each containing 18 or 19 cysteine residues. The role these with high numbers residues, in determining the functional properties flour is unclear. In present study, two transgenic lines bread overexpressing avenin-like gene were generated to investigate effects on dough mixing properties. Sodium dodecyl sulfate sedimentation (SDSS) test and Mixograph analysis demonstrated that overexpression both significantly increased SDSS...
Abstract To solve large-scale unconstrained optimization problems, a modified PRP conjugate gradient algorithm is proposed and found to be interesting because it combines the steepest descent with method successfully fully utilizes their excellent properties. For smooth functions, objective sufficiently information about function previous direction determine next search direction. nonsmooth Moreau–Yosida regularization introduced into algorithm, which simplifies process in addressing complex...
Hilar cholangiocarcinoma is a highly aggressive malignancy originating from the hilar biliary duct epithelium. Due to few effective comprehensive treatments, prognosis of poor. In this study, immunohistochemistry was first used detect and analyze expression Gab1, VEGFR-2, MMP-9 in solid tumors relationships clinical pathological features. Furthermore, Gab1 VEGFR-2 siRNA were interfere cell line ICBD-1 then PI3K/Akt signaling pathway, levels malignant biological behaviors tumor cells. The...
Background Human telomeres, tandem repeats of TTAGGG nucleotides at the ends chromosomes, are essential for maintaining genomic integrity and stability. Results previous epidemiologic studies about association telomere length with risk colorectal cancer (CRC) have been conflicting. Methods A case-control study was conducted in a Han population Wuhan, central China. The relative (RTL) measured peripheral blood leukocytes (PBLs) using quantitative real-time polymerase chain reaction (PCR) 628...