A5060059450- Rheumatoid Arthritis Research and Therapies
- S100 Proteins and Annexins
- Genetics, Bioinformatics, and Biomedical Research
- Clusterin in disease pathology
- Pharmacological Effects of Natural Compounds
- Neurological diseases and metabolism
- Cytokine Signaling Pathways and Interactions
- Genetics, Aging, and Longevity in Model Organisms
- Bioinformatics and Genomic Networks
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Inflammasome and immune disorders
- RNA Research and Splicing
- Immune Cell Function and Interaction
- Algal biology and biofuel production
- Drug-Induced Hepatotoxicity and Protection
- Autoimmune and Inflammatory Disorders Research
- RNA and protein synthesis mechanisms
- Psoriasis: Treatment and Pathogenesis
- Photosynthetic Processes and Mechanisms
- Systemic Sclerosis and Related Diseases
- Natural Compounds in Disease Treatment
- COVID-19 Clinical Research Studies
- Adipose Tissue and Metabolism
- Synthesis and Biological Activity
Tongji Hospital
2019-2024
Huazhong University of Science and Technology
2019-2024
Jiangxi University of Traditional Chinese Medicine
2024
Zhongnan Hospital of Wuhan University
2023-2024
Wuhan University
2023-2024
Beijing Radiation Center
2023-2024
Yunnan University of Traditional Chinese Medicine
2024
Chinese General Hospital College of Nursing and Liberal Arts
2024
Huzhou Central Hospital
2018-2024
Nanjing Drum Tower Hospital
2023
Background: Wutou Decoction (WTD), as a classic prescription, has been generally used to treat rheumatoid arthritis (RA) for two thousand years in China. However, the potential protective effects of WTD on and its possible mechanism have rarely reported. Purpose: The aim this study was explore against RA promising alternative candidate therapy. Methods: A model collagen-induced (CIA) constructed rats assess therapeutic WTD. Histopathological staining, immunofluorescence, western blotting...
Abstract Keratinocyte proliferation and differentiation in epidermis are well-controlled essential for reacting to stimuli such as ultraviolet light. Imbalance between is a characteristic feature of major human skin diseases psoriasis squamous cell carcinoma. However, the effect keratinocyte metabolism on remains largely elusive. We show here that gluconeogenic enzyme fructose-1,6-bisphosphatase 1 (FBP1) promotes while inhibits suppresses development. FBP1 identified among most upregulated...
Thousands of years clinical practice in the treatment joint-related diseases support efficacy and safety Wutou decoction (WTD). Nevertheless, lack pharmacological evidence unclear mechanisms make it difficult for WTD to become a recognized complementary therapy rheumatoid arthritis (RA).This study aimed investigate effect against synovial inflammation RA whether this depends on regulation macrophage polarization.Sprague-Dawley rats were used establish collagen-induced (CIA) model. with low...
Objectives Increasing data about COVID-19 have been acquired from the general population. We aim to further evaluate clinical characteristics of in patients with systemic autoimmune diseases (AIDs). Methods included all confirmed inpatients and AIDs Wuhan Tongji Hospital 29 January 8 March 2020. retrospectively collected analysed information on epidemiology 1255 additional AIDs. Outcomes were followed up until 16 April Results Of COVID-19, median age was 64.0 years 53.1% male. More than half...
Simiao Pill (SM) as a classic prescription of traditional Chinese medicine treatment damp-heat arthralgia, the earliest from 'Cheng Fan Bian Du ', written by Qing Dynasty doctor Zhang Bingcheng. Previous studies have shown that SM has obvious curative effect on rheumatoid arthritis, which provides basis for application in arthritis related complications.Interstitial lung disease (ILD), most severe complication (RA), lacks effective clinical treatments and corresponding animal model. pill is...
This study aimed to investigate the effects of triptolide (TP) on collagen-induced arthritis (CIA) mice and related mechanisms.CIA were administered TP for 35 days. Mouse ankle joints serum antibodies cytokines examined assess therapeutic TP. The ratios Treg, Th1 Th17 cells measured by flow cytometry RT-qPCR. Reverse docking was used characterize binding modes against target proteins. expression STAT3 pathway in CIA evaluated western blotting immunofluorescence staining. spleen lymphocytes...
Objective . This study aimed to investigate whether berberine exerted anti-inflammatory and antiproliferative effects on the fibroblast-like synoviocytes of rheumatoid arthritis (FLS-RA) through regulating lysophosphatidic acid (LPA) function. Methods Firstly, expression levels LPA receptor 1 (LPA ) in RA patients, osteoarthritis (OA) healthy controls were detected. Moreover, molecular docking was employed characterize binding sites predicted protein targets. Later, FLS-RA stimulated using...
Pinelliae rhizoma (PR), one kind of commonly-used Chinese herbs, is generally prescribed to treat various respiratory diseases, including acute lung injury (ALI). However, the accurate bioactive ingredients PR and underlying pharmacological mechanism have both not been fully elucidated. Therefore, this study aimed identify that could alleviate lipopolysaccharide (LPS)-induced ALI explore possible involved. Our results confirmed LPS infection indeed caused inflammatory damage in mice lung,...