A5081134218- Health, Environment, Cognitive Aging
- Nutritional Studies and Diet
- Liver Disease Diagnosis and Treatment
- Folate and B Vitamins Research
- Vitamin D Research Studies
- Hepatitis B Virus Studies
- Hepatitis C virus research
- Physical Activity and Health
- Diet and metabolism studies
- Astronomical Observations and Instrumentation
- Nutrition and Health in Aging
- Obesity, Physical Activity, Diet
- Chronic Kidney Disease and Diabetes
- Sodium Intake and Health
- Blood Pressure and Hypertension Studies
- Astronomy and Astrophysical Research
- Air Quality and Health Impacts
- Dialysis and Renal Disease Management
- Iron Metabolism and Disorders
- Diet, Metabolism, and Disease
- Bipolar Disorder and Treatment
- Artificial Intelligence in Healthcare
- Systemic Sclerosis and Related Diseases
- Gout, Hyperuricemia, Uric Acid
- Alzheimer's disease research and treatments
National Clinical Research
2022-2025
Southern Medical University
2022-2025
Guangzhou Regenerative Medicine and Health Guangdong Laboratory
2022-2025
Nanfang Hospital
2022-2025
Zhejiang University
2015-2025
Huazhong University of Science and Technology
2012-2025
Tongji Hospital
2012-2025
Fudan University
2017-2025
First Affiliated Hospital Zhejiang University
2020-2025
Hôpital Cochin
2023-2025
Abstract Background The MYB superfamily constitutes one of the most abundant groups transcription factors described in plants. Nevertheless, their functions appear to be highly diverse and remain rather unclear. To date, no genome-wide characterization this gene family has been conducted a legume species. Here we report first analysis whole species, soybean ( Glycine max ), including structures, phylogeny, chromosome locations, conserved motifs, expression patterns, as well comparative...
MYB proteins comprise a large family of plant transcription factors, members which perform variety functions in biological processes. To date, no genome-wide characterization this gene has been conducted maize (Zea mays). In the present study, we performed comprehensive computational analysis, to yield complete overview R2R3-MYB maize, including phylogeny, expression patterns, and also its structural functional characteristics. The structure Arabidopsis were highly conserved, indicating that...
Abstract Stimulating the cyclic guanosine monophophate(GMP)‐adenosine monophosphate (AMP) synthase (cGAS)‐stimulator of interferon genes (STING) pathway is a crucial strategy by which bacteria activate tumor immune system. However, limited stimulation capability poses significant challenges in advancing bacterial immunotherapy. Here, an adenosine 5′‐triphosphate (ATP)‐responsive manganese (Mn)‐based material ( E. coli @PDMC‐PEG (polyethylene glycol)) engineered successfully, exhibits...
Probiotics have the potential as biotherapeutic agents for cancer management in preclinical models and human trials by secreting antineoplastic or immunoregulatory tumor microenvironment (TME). However, current probiotics lack ability to dynamically respond unique TME characteristics, leading limited therapeutic accuracy efficacy. Although progress has been made customizing controllable through synthetic biology, engineering process is complex predictability of production relatively low. To...
Abstract Liver disease, a major health concern worldwide, is serious and progressive disorder. Herein, we not only established mouse model of DEN+CCl 4 -induced primary liver disease but also collected clinical human samples to investigate longitudinal alterations in the gut mycobiome. As advanced, integrity was disrupted, mycobiota disturbed models. The metabolites associated with hepatocellular carcinoma (HCC) differed from those cirrhotic phase as follows: levels stercobilin aflatoxin B1...
Abstract Biomass‐derived carbon as energy storage materials have gradually attracted widespread attention due to their low cost, sustainability, and inherent structural advantages. Herein, hard (H‐1200) porous (PC‐800) for sodium‐ion batteries (SIBs), capacitors (SICs) half cells hybrid (SIHCs) been synthesized from the same biomass precursor of Camellia shells through different treatments. H‐1200 by directly high‐temperature carbonization possesses a rational graphitic layer structure...
To identify the major serum biomarkers predicting response to methotrexate (MTX) treatment in patients with early rheumatoid arthritis (RA), we evaluated relationships between individual MTX and various associated factors utilizing (1)H nuclear magnetic resonance ((1)H NMR)-based metabolomic method. Thirty-eight RA were enrolled this cohort study, they received (10 mg/week) orally as monotherapy for 24 weeks. According American College of Rheumatology criteria improvement, clinical...
Background The association of a healthy lifestyle with the prognosis type 2 diabetes remains uncertain. We aimed to evaluate associations and higher American Heart Association's Life's Essential 8 score incident macrovascular microvascular diseases in diabetes. Methods Results A total 13 543 participants baseline free from UK Biobank were included. was determined based on body mass index, smoking, alcohol consumption, physical activity, sleep duration, diet. scores generated metrics...
Objective To examine the long-term association of objectively measured moderate-to-vigorous physical activity (MVPA) and its longitudinal changes with progression to chronic kidney disease (CKD) in patients type 2 diabetes (T2D) overweight/obesity. Methods This study included 1746 participants Look AHEAD trial baseline estimated glomerular filtration rate (eGFR)≥60 mL/min/1.73 m . MVPA was at baseline, year 1, 4 8 using an RT3 accelerometer. The outcome CKD, defined as eGFR<60 mL/min per...
Interleukin 34 (IL-34) and microRNA 21 (miR-21) were found to be involved in the pathological process of rheumatoid arthritis (RA), but details unclear. In this study, we aimed clarify relationship between IL-34 miR-21 RA.IL-34 concentrations serum synovial fluid (SF) patients with RA measured by ELISA. Fibroblast-like cells (FLS) cultured for evaluation STAT3 activation, miR-21, Bax/Bcl-2 expression Western blot real-time PCR. Correlations analyzed clinical features detectable variables...
Hepatitis B virus (HBV) generally causes self-limiting infection in immunocompetent adults, but establishes chronic some adults and most maternally infected infants. Factors determining clearance versus persistence are not fully understood. Hydrodynamic injection (HDI) of HBV replicon plasmid via tail vein results quick adult mice. Here, we report the identification strain-specific mice: one genotype strain, designated BPS, persisted up to 33 weeks ~50% HDI BPS requires viral replication...