A5100457712- Multiple Myeloma Research and Treatments
- Platelet Disorders and Treatments
- COVID-19 Clinical Research Studies
- Osteoarthritis Treatment and Mechanisms
- Hematological disorders and diagnostics
- Inflammatory mediators and NSAID effects
- Drug-Induced Ocular Toxicity
- Rheumatoid Arthritis Research and Therapies
- Infectious Encephalopathies and Encephalitis
- Iron Metabolism and Disorders
- Spondyloarthritis Studies and Treatments
- Mesenchymal stem cell research
- Inflammasome and immune disorders
- Erythropoietin and Anemia Treatment
- Bone health and treatments
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Musculoskeletal synovial abnormalities and treatments
- Renal Diseases and Glomerulopathies
- Tendon Structure and Treatment
- Chronic Lymphocytic Leukemia Research
- Inflammatory Biomarkers in Disease Prognosis
- Metabolism and Genetic Disorders
- Streptococcal Infections and Treatments
- Cytokine Signaling Pathways and Interactions
- Berberine and alkaloids research
Ningbo University
2024
University of Verona
2023
University of Science and Technology of China
2023
Khoo Teck Puat Hospital
2023
Capital Medical University
2020-2022
Beijing Chao-Yang Hospital
2020-2022
Chinese Academy of Medical Sciences & Peking Union Medical College
2022
Nanjing Medical University
2022
Jiangsu Province Hospital
2022
Southern Medical University Shenzhen Hospital
2020-2021
Interleukin 34 (IL-34) and microRNA 21 (miR-21) were found to be involved in the pathological process of rheumatoid arthritis (RA), but details unclear. In this study, we aimed clarify relationship between IL-34 miR-21 RA.IL-34 concentrations serum synovial fluid (SF) patients with RA measured by ELISA. Fibroblast-like cells (FLS) cultured for evaluation STAT3 activation, miR-21, Bax/Bcl-2 expression Western blot real-time PCR. Correlations analyzed clinical features detectable variables...
Objective Multiple myeloma (MM) varies in clinical behavior, response to treatment and prognosis due the heterogeneity of disease. Data on association between immunoparesis status during nontransplant MM patients are limited.
Abstract Three-dimensional fat-suppressed spoiled gradient magnetic resonance imaging can be used to observe cartilages with high resolution. To quantify and compare the T1ρ T2 relaxation times of knee articular cartilage between healthy asymptomatic adults patients osteoarthritis (OA). This was a retrospective study 53 symptomatic OA (6 males 47 females; aged 57.6 ± 10.0 years) 26 (11 15 31.7 12.2 from Ruijin Hospital. were quantified using sagittal multi-echo mapping sequences (3.0-T...
Objective: The correlation between low triiodothyronine (T3) syndrome and shorter survival in malignant tumor patients has been increasingly reported. objective of the present study was to investigate association T3 multiple myeloma (MM) patients. Methods: A total 201 newly diagnosed MM were included this retrospective study. All participants divided into 2 groups based on serum free (FT3) level: group (FT3 < 2.3 pg/mL) non-low ≥ pg/mL). Baseline clinical characteristics, overall (OS)...
Objective To investigate the prevalence of depression or anxiety in patient with multiple myeloma (MM) China during maintenance treatment and its associated influencing factors. Methods Patients MM ( n = 160) received therapy, control subjects (without MM, matched on age, sex, BMI were recruited. completed questionnaires, including Patient Health Questionnaire-9 (PHQ-9), Generalized Anxiety Disorder 7-item Scale (GAD-7), Verbal Pain Rating (VPRS). Data Clinical characteristics, biochemical...
Clinical studies indicate that recombinant tumor necrosis factor receptor:Fc fusion protein (rhTNFR:Fc) quickly alleviates symptoms and physical signs of active Ankylosing Spondylitis (AS), improving the manifestation spinal inflammation on radiological imaging. However, regulatory mechanism rhTNFR:Fc in chemokine pathway is unclear. Thus we study phlogogenic activity CXCL16/CXCR6 AS related rhTNFR: Fc treatment.Thirty-two cases were treated with for 3 consecutive months. response was...
<h3>Background</h3> Systemic lupus erythematosus (SLE) is a multi-system autoimmune disease characterized by aberrant expansion of B cells. The cell-stimulating molecules, cell activating factor/a proliferation-inducing ligand (BAFF/APRIL), are critical factors in promoting the proliferation and differentiation cells thus play prominent role pathogenesis SLE. There two types BAFF/APRIL-targeted biological agents being approved as an add-on therapy for patients with active SLE China,...
Since the COVID-19 pandemic, several therapeutic agents have been used in management. However, results were controversial. Here, we aimed to evaluate efficacy and safety of hydroxychloroquine (HCQ)/chloroquine (CQ) COVID-19. We retrospectively reviewed medical charts patients with admitted an inpatient ward Wuhan from 2020/Feb/08 2020/Mar/05. Patients HCQ/CQ age, gender, disease severity matched ones without selected at a 1:2 ratio. The clinical, laboratory imaging findings compared between...
B cells play a central role in the pathogenesis of immune thrombocytopenia (ITP) by participating humoral immunity. Meanwhile, regulatory (Bregs), one subset cells, express negative effect on ITP. Mesenchymal stem (MSCs) have been demonstrated ability to induce immunosuppression, and stromal cell-derived factor-1α (SDF-1α) plays an important migration survival MSCs. To investigate mechanism SDF-1α controlling umbilical cord-derived MSCs (UC-MSCs) inducing cell differentiation patients with...
This study was to evaluate the differential diagnostic value of serum Hepcidin in elderly patients with iron deficiency anemia (IDA)and chronic disease (ACD).The group IDA consisted 28 patients, and ACD 21 control included 25 healthy people. measured by ELISA; WBC,RBC counts were assayed haematology analyzer; ferritin level using radioimmunoassay; C-reaction protein(CRP) levels a biochemical analyzer.Hepcidin between three groups significantly different (P < 0.01); ferritin,WBC CRP higher...
Abstract Background : We aim to evaluate the treatment value and safety of hydroxychloroquine (HCQ)/ chloroquine (CQ) in COVID-19. Methods retrospectively reviewed medical charts patients with COVID-19 admitted an inpatient ward Wuhan from 2020. 02. 08 03. 05. Patients HCQ/ CQ age, gender, disease severity matched ones without were selected at a 1:2 ratio. The clinical, laboratory imaging findings compared between these two groups. multivariate linear regression analysis was performed...
Introduction: Abnormal iron metabolism has received increasing attention in the development of liver injury. Recent findings have shown that may be associated with elevated alanine aminotransferase (ALT), and aim this study was to investigate relationship between metabolism-related indicators ALT.Methods: Based on data Chinese adults aged 18 years older China Health Nutrition Survey (CHNS), we analyzed correlations glucose, lipid, ALT, explored affecting ALT levels using binary logistic...