A5019101783- Mesenchymal stem cell research
- Sperm and Testicular Function
- Tissue Engineering and Regenerative Medicine
- Hormonal and reproductive studies
- Nerve injury and regeneration
- Reproductive Biology and Fertility
- Neuroinflammation and Neurodegeneration Mechanisms
- Healthcare and Venom Research
- Cancer Cells and Metastasis
- Cancer-related Molecular Pathways
- Spinal Cord Injury Research
- Inflammation biomarkers and pathways
- Orthopedic Infections and Treatments
- Total Knee Arthroplasty Outcomes
- Diabetes Treatment and Management
- Bladder and Urothelial Cancer Treatments
- Electrospun Nanofibers in Biomedical Applications
- Neurogenesis and neuroplasticity mechanisms
- Orthopaedic implants and arthroplasty
- Cardiac Fibrosis and Remodeling
- Radiomics and Machine Learning in Medical Imaging
- Helicobacter pylori-related gastroenterology studies
- Effects and risks of endocrine disrupting chemicals
- Ginger and Zingiberaceae research
- Apelin-related biomedical research
Jiangsu Provincial Hospital of Traditional Chinese Medicine
2025
Nanjing University
2025
Sun Yat-sen University
2014-2024
University Radiology
2019
Xi'an Jiaotong University
2019
Third Affiliated Hospital of Sun Yat-sen University
2018
Kyung Hee University
2010-2017
Northwest A&F University
2017
Ruijin Hospital
2014-2016
Shanghai Jiao Tong University
2014
The ability to identify and isolate lineage-specific stem cells from adult tissues could facilitate cell replacement therapy. Leydig (LCs) are the primary source of androgen in mammalian testis, prospective identification (SLCs) may offer new opportunities for treating testosterone deficiency. Here, a transgenic mouse model expressing GFP driven by Nestin (Nes) promoter, we observed Nes-GFP+ located testicular interstitial compartment where SLCs normally reside. We showed that these...
The potential benefits or the tissue-damaging effects of inflammatory response after central nervous system injuries have long been disputed. Recent studies noted that substance P (SP), a neuropeptide, plays an important role in wound-healing process by recruiting bone marrow stem cells to injured tissue. In this study, we examined whether SP can enhance recovery from spinal cord injury (SCI) Sprague-Dawley rats through its known function cell mobilization and/or modulation inflammation. We...
Zingiber officinale Roscoe, Ginger, has been used in folk medicine as a medicinal plant, well spice and food many countries. This research was carried out to evaluate the antiparasitic effect of ginger root extract (GE) GE/F1 (fraction 1 obtained from GE) against Toxoplasma gondii (T. gondii) vitro vivo. The effects GE proliferation T. gondii-infected C6 cells were evaluated by several indicators such an MTT assay, nuclear staining, immunofluorescence apoptotic proteins animal testing....
Abstract Stem Leydig cell (SLC) transplantation could provide a new strategy for treating the testosterone deficiency. Our previous study demonstrated that CD51 (also called integrin αv) might be putative surface marker SLCs, but physiological function and efficacy of CD51+ SLCs treatment remain unclear. Here, we explore potential therapeutic benefits whether these transplanted cells can regulated by hypothalamic-pituitary-gonadal (HPG) axis. were isolated from testes 12-weeks-old C57BL/6...
Hermetia illucens larvae have been used in Europe and America as a medical resource medicinal insect for the treatment of skin damage such burns wound healing. This study was carried out to evaluate effect new substance causing antibacterial activity against various pathogenic bacteria, including methicillin-resistant Staphylococcus aureus (MRSA). The hexanedioic acid determined using different antimicrobial indicators turbidometric assay, resazurin agar disk diffusion. Hexanedioic showed...
Mesenchymal stromal cells (MSCs) show potential for treating cardiovascular diseases, but their therapeutic efficacy exhibits significant heterogeneity depending on the tissue of origin. This study sought to identify an optimal source MSCs disease therapy. We demonstrated that Nestin was a suitable marker cardiac (Nes+cMSCs), which were identified by self-renewal ability, tri-lineage differentiation potential, and expression MSC markers. Furthermore, compared with bone marrow-derived...
Previously, we have reported that substance P (SP) enhanced functional recovery from spinal cord injury (SCI) possibly by the anti-inflammatory modulation associated with induction of M2-type macrophages at injured lesion. In this study, explored cytokine expression profiles and apoptotic cell death in lesion site SCI after an immediate intravenous injection SP. SP increased levels interleukin-4 (IL-4), IL-6, IL-10 day 1 approximately 2-, 9-, 10-folds when compared control SCI, respectively....
Bone-derived mesenchymal stem cell (BMSC) transplantation has been reported to be effective for the treatment of ischemic heart disease, but whether BMSCs are optimal type remains under debate. Increasing numbers studies have shown that Nestin, an intermediate filament protein, is a potential marker MSCs, which raises question Nestin+ cells in may play more crucial role myocardial repair. were isolated using flow cytometry by gating CD45− Ter119− CD31− from compact bone Nestin-GFP transgenic...
Corni Fructus has traditionally been used as herbal medicine for the treatment of tuberculosis, asthma, hepatitis, and chronic nephritis in Korea, Japan, China. This research was carried out to evaluate proliferative-inhibitory effect CF extracts against cancer cells identify new pro-substance from medicinal plants. Among these extracted KCF (Korean Fructus), JCF (Japanese Fructus) CCF (Chinese strongly induced anti-proliferation a dose-dependent manner compared with other extracts....
Male infertility has become an important health problem that is primarily caused by testicular dysfunction with abnormal spermatogenesis. In this study, we demonstrated the neuropeptide, substance P (SP), essential for spermatogonia proliferation in a seminiferous tubule culture system. addition, SP (5 nmol/kg) treatment markedly restored spermatogenesis, improved sperm quality, and increased number of ZBTB16
Background The imaging evaluation of pain in patients who have had a hip arthroplasty (HA) is challenging, and traditional techniques, including magnetic resonance (MRI) computerized tomography (CT), are limited by metallic artifact. purpose the present study was to investigate use modified MRI techniques visualize periprosthetic soft tissues bone-implant interface, evaluate value for assessment with painful arthroplasty. Methods Fifty-six hips fifty-six following primary HA were assessed...
We analyzed parasitic diseases diagnosed by tissue biopsy specimens at KyungHee Medical Center (KMC) from 1984 to 2005. The total number of parasite infection cases was 150 (0.07%) out the 211,859 submitted for histopathological examinations. They consisted 62 cysticercosis, 23 sparganosis, 16 paragonimiasis, 15 amebiasis, 11 anisakiasis, clonorchiasis, 3 ascariasis, 2 scabies, enterobiasis, trichuriasis, 1 leishmaniasis, taeniasis, and thelaziasis. Out cysticercosis cases, 55 were detected...
Abstract To evaluate the efficacy of magnetic resonance imaging (MRI) parameter optimizations for diagnosis periprosthetic infection and tumor recurrence in joint replacement patients. We compared quality images 16 patients that were recorded using optimized MRI parameters with without view angle tilting (VAT) correction at 1.5 T coronal fast-spin-echo T2-weighted MRI. The data 86 pain after hip 67 who received resection bone cancer retrospectively analyzed to identify features useful...
Adriamycin (ADR) is a potent antineoplastic agent, but long-term treatment limited by its cumulative, life-threatening cardiomyopathy. Recently, few reports have shown that pentoxifylline (PTX) might produce cardioprotection in cardiac dysfunction. Here, we investigated the protective effects of PTX on ADR-induced cardiomyopathy rats. Male rats were randomly assigned either to saline, ADR (adriamycin, 5 mg/kg/week), or A mg/kg/week) + (pentoxifylline, 50 mg/kg/day) groups. After 3 weeks,...
Abstract Three-dimensional fat-suppressed spoiled gradient magnetic resonance imaging can be used to observe cartilages with high resolution. To quantify and compare the T1ρ T2 relaxation times of knee articular cartilage between healthy asymptomatic adults patients osteoarthritis (OA). This was a retrospective study 53 symptomatic OA (6 males 47 females; aged 57.6 ± 10.0 years) 26 (11 15 31.7 12.2 from Ruijin Hospital. were quantified using sagittal multi-echo mapping sequences (3.0-T...
Lung cancer has been considered as one of the most important causes cancer-related mortality worldwide. To predict lung cancer, researchers identified several molecular markers. However, many underlying markers remain unclear. One these is Rab GDP dissociation inhibitor beta (GDIβ), which related to tumorigenicity, development and invasion. This study was designed analyze biological characteristics GDIβ detect mRNA protein expressions in cells; this also aimed investigate functions...
Background: Angiostrongylus cantonensis infection can cause demyelination in the central nervous system, and there is no effective treatment.Methods: We used dexamethasone, Tanshinone IIA (TSIIA) Cryptotanshinone(Two traditional Chinese medicine monomers) combination with albendazole (AB, a standard anti-helminthic compound) to observe their therapeutic effect on A. cantonensis-infected mice.Luxol fast blue staining electron microscope of myelin sheath, Oligodendrocyte (OL) number basic...
Objective: Many tissues contained resident mesenchymal stromal/stem cells (MSCs) that facilitated tissue hemostasis and repair. However, there is no typical marker to identify the cardiac MSCs. We aimed determine if CD51 could be an optimal of MSCs assess their therapeutic potential for mice with acute myocardial infarction (AMI). Methods: Cardiac-derived + CD31 – CD45 Ter119 (named cMSCs) were isolated from C57BL/6 mice(7-day-old) by flow cytometry. The cMSCs characterized proliferation...