A5101663665- Spinal Cord Injury Research
- Mesenchymal stem cell research
- Conducting polymers and applications
- Neuroscience and Neural Engineering
- Inflammation biomarkers and pathways
- Immune cells in cancer
- Neuroinflammation and Neurodegeneration Mechanisms
- Electrochemical sensors and biosensors
- Fuel Cells and Related Materials
- Supercapacitor Materials and Fabrication
- Cell Adhesion Molecules Research
- Force Microscopy Techniques and Applications
- Epigenetics and DNA Methylation
- Wound Healing and Treatments
- Polyoxometalates: Synthesis and Applications
- Dermatology and Skin Diseases
- Reproductive System and Pregnancy
- Graphene research and applications
- Reproductive Physiology in Livestock
- Histone Deacetylase Inhibitors Research
- Gas Sensing Nanomaterials and Sensors
- Immune Cell Function and Interaction
- Immune Response and Inflammation
- Telomeres, Telomerase, and Senescence
- Endometriosis Research and Treatment
Korea Research Institute of Chemical Technology
2021
Yonsei University
2004-2021
Kyung Hee University
2008-2017
Sungkyunkwan University
2008
Kyung Hee University Medical Center
2008
Korea University Medical Center
2006
Macrophage polarization plays an important role in tissue damage and repair. In this study, we show that Substance-P (SP) can directly induce M2 of inflammatory macrophages. SP induced the differentiation GM-CSF-differentiated pro-inflammatory macrophages into alternatively activated phagocytic like (M2SP) through direct activation PI3K/Akt/mTOR/S6kinase pathway induction Arginase-1, CD163, CD206, all which were nullified by pretreatment with neurokinin-1 receptor (NK-1R) antagonist RP67580...
The potential benefits or the tissue-damaging effects of inflammatory response after central nervous system injuries have long been disputed. Recent studies noted that substance P (SP), a neuropeptide, plays an important role in wound-healing process by recruiting bone marrow stem cells to injured tissue. In this study, we examined whether SP can enhance recovery from spinal cord injury (SCI) Sprague-Dawley rats through its known function cell mobilization and/or modulation inflammation. We...
Decorating graphene with nanoparticles is an effective method for improving gas selectivity and sensitivity of graphene-based chemical sensors. We report herein the enhancement improved response a sensor by decorating synthesized Ag2S nanoparticles. To synthesize uniformly sized nanoparticles, we used ultrasonic irradiation method, then were decorated onto uniformly, using simple spin coating method. Gas responses resulting tested volatile organic compounds (VOCs) such as acetone, ethanol,...
Previously, we have reported that substance P (SP) enhanced functional recovery from spinal cord injury (SCI) possibly by the anti-inflammatory modulation associated with induction of M2-type macrophages at injured lesion. In this study, explored cytokine expression profiles and apoptotic cell death in lesion site SCI after an immediate intravenous injection SP. SP increased levels interleukin-4 (IL-4), IL-6, IL-10 day 1 approximately 2-, 9-, 10-folds when compared control SCI, respectively....
We investigated the effect by chemical fixative on human fibroblast cells (HFCs) in order to make nano-scale images using atomic force microscopy (AFM). The cell fixation needed be optimized as prerequisite step for preparation before analysis. AFM imaging after optimal wet can provide practical, simple and fast technique scanning living cells. In this study, topography amplitude optic of HFCs which were fixed with phosphate buffered saline (PBS), 2:1 ethanol:acetic acid, 4% glutaraldehyde...
In order to detect L-glutamate, we immobilized L-glutamate oxidase (GLOD) on the probe-type carbon nanotube (CNT) network junctions by a non-covalent functionalized method preserve their electronic characteristics. After immobilizing GLOD CNT network, excess reactive groups of linker molecule remaining its surface were deactivated and blocked ethanolamine. The electrical property GLOD-immobilized transistor was characterized as source-drain current that depended liquid gate voltage. real...