A5100391495- Cancer, Lipids, and Metabolism
- Mesenchymal stem cell research
- Clostridium difficile and Clostridium perfringens research
- Tissue Engineering and Regenerative Medicine
- Inflammatory Biomarkers in Disease Prognosis
- Sepsis Diagnosis and Treatment
- Microscopic Colitis
- Nerve injury and regeneration
- Inflammatory mediators and NSAID effects
- Liver Disease Diagnosis and Treatment
- Nosocomial Infections in ICU
- Epigenetics and DNA Methylation
- Cancer Cells and Metastasis
- Reconstructive Surgery and Microvascular Techniques
- Cancer Mechanisms and Therapy
- Vascular Procedures and Complications
- Pancreatic and Hepatic Oncology Research
- Breast Cancer Treatment Studies
- Nuclear Receptors and Signaling
- Bone fractures and treatments
- Wnt/β-catenin signaling in development and cancer
- Cancer-related molecular mechanisms research
- Neurological Complications and Syndromes
- Heat shock proteins research
- Phagocytosis and Immune Regulation
Fujian Medical University
2024
The First Affiliated Hospital, Sun Yat-sen University
2010-2024
Sun Yat-sen University
2010-2024
First Affiliated Hospital of GuangXi Medical University
2024
Air Force Medical University
2020
Xuzhou Medical College
2020
Second People’s Hospital of Huai’an
2020
Mianyang Central Hospital
2019
Southwest Medical University
2019
Huizhou Central People's Hospital
2018
Aberrant activation of Wnt signaling is a crucial event in tumor development and metastasis.Wnt commonly divided into canonical non-canonical pathways based on whether β-catenin activated (canonical).The two are initiated by ligand binding to the surface Frizzled (FZD) receptors, regulate cancer stem cell self-renewal epithelial-mesenchymal transition (EMT).Frizzled 7 (FZD7), member family, promotes proliferation invasiveness many cancers, suggesting that FZD7 transmitting important for...
// Jian Li 1, 2, 3, * , Zhijuan Deng Zhu Wang 4 Dong 5 Longjuan Zhang 1 Qiao Su 8 Yingrong Lai 6 Bin Zexing Luo Xu Chen 7 Yu Xiaohui Huang Jieyi Ma Wenjian Jiong Bi Xinyuan Guan 2 Laboratory of General Surgery, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou 510080, China State Key Oncology in South China, University Cancer Center, 510060, 3 Department Clinical Laboratory, Memorial 510120, Medical Ultrasonics Institute Diagnostic and Interventional Ultrasound, Pathology,...
In this study, we aimed to evaluate the potential of tissue-engineered nerve grafts created from acellular allogenic tissues combined with autologous bone marrow stromal cells (BMSCs) for repairing large peripheral lesions. a rhesus monkey model, 2.5-cm-long gap was in radial nerve, followed by implantation either autografts or allografts seeded BMSCs, Schwann (SCs), no cells. Five months after surgery regeneration assessed functionally, electrophysiologically, and histomorphometrically....
Macrophage migration inhibitory factor (MIF) is a pro‑inflammatory cytokine that serves important roles in cancer. MIF overexpression frequently observed numerous human cancer types, including pancreatic carcinoma. However, the prognostic value and function of ductal adenocarcinoma (PDAC) have not been fully elucidated. In present study, upregulation expression PDAC tissue compared with adjacent normal was observed. Furthermore, identified to be significantly associated poor survival rates...
Monocyte distribution width (MDW) is a quantitative measurement of monocyte anisocytosis and has been proposed as an efficient marker for early sepsis detection. This study aimed to assess the prognostic potential MDW in septic patients.
Abstract This study aimed to investigate the protective effects of EGb761, a Ginkgo Biloba extract, against brain death-induced kidney injury. Sixty male Sprague Dawley rats were randomly divided into six groups: sham, brain-death (BD), BD + EGb b48h (48 hours before BD), 2 h (2 after 1 h, and 0.5 h. Six BD, serum sample tissues collected for analyses. The levels blood urea nitrogen (BUN) creatinine significantly elevated in group than sham group. In all EGb761-treated animals except Gb...
Intimal hyperplasia, the key event of arterial restenosis, is a result cell proliferation and migration. Atorvastatin exerts an inhibitory effect on migration, but mechanism remains largely unknown. p16, as well-known tumor suppressor, was also reported to suppress growth with unclear mechanism. In this study, we demonstrated that atorvastatin represses migration in vascular smooth muscle cells (VSMCs) process mediated by p16. Furthermore, found DNA methylation p16 promoter reduced...
Abstract Cell-in-cell structures (CICs) refer to a type of unique structure with one or more cells within another one, whose biological outcomes are poorly understood. The present study aims investigate the effects CICs formation on tumor progression. Using genetically marked hepatocellular cancer cell lines, we explored possibility that might acquire genetic information and malignant phenotypes from parental undergoing formation. showed derivatives, isolated formed between two...
Retroperitoneal abscesses caused by donor-derived Carbapenem-Resistant Klebsiella Pneumoniae (CRKP) infections are rare and often challenging to diagnose early due a lack of specific symptoms. In case one, 64-year-old male presented with unexplained fever emaciation three months after undergoing kidney transplant for end-stage renal disease. Metagenomic Next-Generation Sequencing identified CRKP in peripheral blood samples, CT scans confirmed retroperitoneal abscess. Considering the...
Abstract Objective In this study, the association between preoperative levels of serum liver enzymes and overall survival (OS) was evaluated in patients with resectable pancreatic cancer. Methods Preoperative alanine aminotransferase (ALT), aspartate aminotransferases (AST), γ-glutamyltransferase, alkaline phosphatase, lactate dehydrogenase 101 ductal adenocarcinoma (PDAC) were collected. Univariate multivariate Cox hazard models used to identify independent variables associated OS cohort....
To explore the relationship between changes in lipid profiles and intensity of inflammatory response disease severity patients with sepsis, order to find a biomarker that can quickly evaluate condition prognosis sepsis.A retrospective analysis was performed on 449 sepsis admitted department critical care medicine First Affiliated Hospital Zhengzhou University from October 2019 May 2021, 355 without hospitalized same period served as control. The general demographic data, blood other clinical...
With the evolution of distributed energy aggregation technology, virtual power plants have emerged as a transformative paradigm for trading, aggregating and optimizing resources such generation, storage, adjustable loads. However, this new landscape introduces uncertainty security risks to trading. Blockchain with its tamper resistance, trustworthiness, decentralization, traceability characteristics, offers natural fit While blockchain-based trading systems improved reliability traditional...
Abstract Introduction Candidemia can be a significant cause of death in immunosuppressed or debilitated patients particularly. Abnormalities the instrumental cytograms some hematological analyzers, such as Mindray BC‐6800Plus, related to circulating Candida. We studied possible diagnostic usefulness this information. Methods A fungal bloodstream infection has been simulated by adding aliquots Candida albicans , parapsilosis and glabrata 75 leftovers anonymized peripheral blood samples....
Abstract Cell population data (CPD) is regarded as the fingerprint of a blood cell at given moment. CPD parameters harbor information associated with morphology and can be automatically generated using modern hematological analyzers. Various studies have revealed many unique clinical applications for CPD, especially infectious diseases, such sepsis. For example, one monocyte‐related parameter monocyte distribution width (MDW), which Beckman Coulter analyzer. MDW has received FDA CE approval...