A5100410050- Advanced Neuroimaging Techniques and Applications
- Advanced MRI Techniques and Applications
- Functional Brain Connectivity Studies
- Mesenchymal stem cell research
- Nerve injury and regeneration
- Image and Signal Denoising Methods
- Peripheral Nerve Disorders
- Neuroinflammation and Neurodegeneration Mechanisms
- Advanced Image Processing Techniques
- Glioma Diagnosis and Treatment
- Orthopedic Surgery and Rehabilitation
- Genetic Neurodegenerative Diseases
- Neurogenesis and neuroplasticity mechanisms
- Botulinum Toxin and Related Neurological Disorders
- Generative Adversarial Networks and Image Synthesis
- Pain Mechanisms and Treatments
- Neurological and metabolic disorders
- Brain Tumor Detection and Classification
- Circadian rhythm and melatonin
- Prenatal Substance Exposure Effects
- Trigeminal Neuralgia and Treatments
- Intracerebral and Subarachnoid Hemorrhage Research
- Wound Healing and Treatments
- Ophthalmology and Eye Disorders
- Effects and risks of endocrine disrupting chemicals
Shenzhen University Health Science Center
2017-2024
Peking University Shenzhen Hospital
2023
Guizhou Minzu University
2023
Guizhou University
2020-2023
Beijing Institute of Technology
2023
University of Siena
2021
Chinese People's Armed Police Force
2020
Logistics University of People's Armed Police Force
2020
National University Health System
2019
Shenzhen University
2014-2019
Recently, conditional diffusion models have gained popularity in numerous applications due to their exceptional generation ability. However, many existing methods are training-required. They need train a time-dependent classifier or condition-dependent score estimator, which increases the cost of constructing and is inconvenient transfer across different conditions. Some current works aim overcome this limitation by proposing training-free solutions, but most can only be applied specific...
Background Alcohol use disorder ( AUD ) is known to have adverse effects on brain structure and function. Multimodal assessments investigating volumetric, diffusion, cognitive characteristics may facilitate understanding of the consequences long‐term alcohol circuitry, their structural impairment patterns, impact function in . Methods Voxel‐ surface‐based volumetric estimations, diffusion tensor imaging DTI ), neuropsychological tests were performed 60 individuals: 30 abstinent individuals...
Purpose: This study aimed to identify brain areas with white matter changes that contribute motor recovery of affected limbs during acute sub-acute phases subcortical infarction. Methods: Diffusion tensor imaging was performed 1, 4, and 12 weeks after stroke onset in 18 patients acu te infarct, age- risk factor-matched controls. Fugl-Meyer scale used assess levels impairment, Statistical Parametric Mapping applied determine fractional anisotropy (FA) for the entire order correlated recovery....
Purpose Pseudoprogression (PsP) can mimic true tumor progression (TTP) on magnetic resonance imaging in patients with glioblastoma multiform (GBM). The phenotypical similarity between PsP and TTP makes it a challenging task for physicians to distinguish these entities. So far, no approved biomarkers or computer‐aided diagnosis systems have been used clinically this purpose. Methods To address challenge, the authors developed an objective classification system based longitudinal diffusion...
Structural MRI (sMRI)-identified tissue "growth" after neuropsychological training has been reported in many studies but the origins of those apparent changes (ATC) still remain elusive. One possible contributor to ATC is brain perfusion since T1-weighted MRI, tool used identify ATC, sensitive perfusion-change induced T1 alterations. To test hypothetical contribution sMRI data were acquired before and short-term global regional manipulations via intaking a 200 mg caffeine pill performing...
Parkinson's disease (PD) has been showed perfusion and neural activity alterations in specific regions, such as the motor visual networks; however, clinical significance of coupling changes is still unknown. To identify how neurovascular during pathophysiology PD, patients healthy controls underwent multiparametric magnetic resonance imaging to measure organization segregation integration using amplitude low-frequency fluctuation (ALFF) functional connectivity strength (FCS), vascular...
Intracerebral hemorrhage (ICH) is associated with high morbidity and mortality rates. However, extant investigations have mainly focused on gray matter injury within the primary site after ICH rather than white (WM) in brain spinal cord. This focus partly accounts for diminished therapeutic discovery. Recent evidence suggests that chondroitin sulphate proteoglycans (CSPG), which can bind to neural transmembrane protein tyrosine phosphatase-sigma (PTPσ), may facilitate axonal regrowth...
<b><i>Background:</i></b> Melatonin has shown a protective effect against various oxidative damages in the nervous system. Our previous studies have also confirmed its on behavioral dysfunction of experimental rats and injury striatal interneurons induced by 3-nitropropionic acid. The present study aimed to further determine melatonin projection neurons <b><i>Methods:</i></b> Classic histology, immunohistochemistry, Western blotting...
We previously demonstrated that overexpression of tropomyosin receptor kinase A (TrkA) promotes the survival and Schwann cell-like differentiation bone marrow stromal stem cells in nerve grafts, thereby enhancing regeneration functional recovery peripheral nerve. In present study, we investigated molecular mechanisms underlying neuroprotective effects TrkA seeded into grafts. Bone from Sprague-Dawley rats were infected with recombinant lentivirus vector expressing rat TrkA, TrkA-shRNA or...
Aim . We report the dynamic anatomical sequence of human cortical gray matter development from late childhood to young adults using VBM and ROI-based methods. Method The structural MRI 91 normal individuals ranging in age 6 26 years was obtained GMV for each region measured. Results Our results showed that earliest loss occurred left olfactory, right precuneus, caudate, putamen, pallidum, middle temporal gyrus. In addition, trajectory maturational aging a linear decline on both lobes...
Diffusion tensor imaging (DTI) is a promising technique for non-invasively investigating the myocardial fiber structures of human heart. However, low signal-to-noise ratio (SNR) has been major limit cardiac DTI to prevent us from detecting myocardium structure accurately. Therefore, it important remove effect noise on diffusion weighted (DW) images.Although conventional and deep learning-based denoising methods have shown potential deal with effectively in DW images, most them are redundant...
Recently, conditional diffusion models have gained popularity in numerous applications due to their exceptional generation ability. However, many existing methods are training-required. They need train a time-dependent classifier or condition-dependent score estimator, which increases the cost of constructing and is inconvenient transfer across different conditions. Some current works aim overcome this limitation by proposing training-free solutions, but most can only be applied specific...
This study examined white matter integrity in patients with left-sided hemifacial spasm (HFS) using diffusion tensor imaging (DTI). Thirty-six HFS (mean age 53.24 ± 8.16 years) and 36 healthy volunteers 53.92 7.73 were recruited. Tract-based spatial statistics (TBSS) analysis revealed significantly increased fractional anisotropy (FA) of bilateral superior longitudinal fasciculus (P < 0.05, family-wise error corrected), trends for radial diffusivity to decrease. We inferred that the results...
Abstract Background: Compressed sensing magnetic resonance imaging (CS-MRI) is a promising technique for accelerating MRI speed. However, image quality in CS-MRI still pertinent problem. In particular, there little work on reducing aliasing artefacts compressed diffusion tensor (CS-DTI), which constitute serious obstacle to obtaining high-quality images. Method: We propose CS-DTI de-aliasing method based conditional generative adversarial (cGAN), called CS-GAN, tackle problems with highly...
Chronic pain is a growing global health problem affecting at least 10% of the world's population. However, current chronic treatments are inadequate. Voltage-gated sodium channels (Navs) play pivotal role in regulating neuronal excitability and signal transmission thus main targets for nonopioid painkiller development, especially those preferentially expressed dorsal root ganglial (DRG) neurons, such as Nav1.6, Nav1.7, Nav1.8. In this study, we screened virtual hits from dihydrobenzofuran...
Abstract Spatial resolution of diffusion tensor images is usually compromised to accelerate the acquisitions, and state‐of‐the‐art (SOTA) image super‐resolution (SR) reconstruction methods are commonly based on supervised learning models. Considering that matched low‐resolution (LR) high‐resolution (HR) diffusion‐weighted (DW) pairs not readily available, we propose a semi‐supervised DW SR method multiple references (MRSR) extracted from other subjects. In MRSR, prior information HR...