A5100385051- Retinal Diseases and Treatments
- Glaucoma and retinal disorders
- Retinal Imaging and Analysis
- Retinopathy of Prematurity Studies
- Retinoids in leukemia and cellular processes
- Autophagy in Disease and Therapy
- Retinal and Macular Surgery
- Advanced Glycation End Products research
- Intraocular Surgery and Lenses
- Retinal and Optic Conditions
- Inflammasome and immune disorders
- Apelin-related biomedical research
- Heme Oxygenase-1 and Carbon Monoxide
- Corneal surgery and disorders
- Regulation of Appetite and Obesity
- Acute Kidney Injury Research
- Extracellular vesicles in disease
- Neurological Disorders and Treatments
- Retinal Development and Disorders
- Educational Robotics and Engineering
- Bioactive Natural Diterpenoids Research
- Digital Imaging for Blood Diseases
- Dendrimers and Hyperbranched Polymers
- Pancreatic and Hepatic Oncology Research
- Chemotherapy-induced organ toxicity mitigation
University of Shanghai for Science and Technology
2023-2024
Xi'an Medical University
2015-2024
Yunnan University of Traditional Chinese Medicine
2023
The Central Hospital of Shaoyang
2023
TCM-Intigrated Cancer Center of Southern Medical University
2022-2023
Army Medical University
2023
Xihua University
2023
Beijing Tongren Hospital
2022
Capital Medical University
2022
Institute of Ophthalmology
2022
purpose. Proinflammatory cytokines in degenerative diseases can lead to the loss of normal physiology and destruction surrounding tissues. In present study, physiological responses human fetal retinal pigment epithelia (hfRPE) were examined vitro after polarized activation proinflammatory cytokine receptors. methods. Primary cultures hfRPE stimulated with an inflammatory mixture (ICM): interleukin (IL)-1β, tumor necrosis factor (TNF)-α, interferon (IFN)-γ. Western blot analysis...
Abstract Background Pilots must process multiple streams of information simultaneously. Mental workload is one the main issues in man–machine interactive mode when dealing with tasks. This study aimed to combine functional near‐infrared spectroscopy (fNIRS) and electrocardiogram (ECG) detect changes mental during multitasking a simulated flight. Methods Twenty‐six participants performed three tasks at different levels. These levels were set by varying number subtasks. fNIRS ECG signals...
Abstract Adiponectin, one of the adipose‐derived hormone with metabolic activity, has been reported to conversely affect angiogenesis endothelial cells in vitro. The previous study animal models demonstrated that adiponectin a protective role retinal vascular injury following pathological stimuli. However, clinical research regarding relationship between plasma level and diabetic retinopathy (DR) are inconclusive. aim this was investigate effect on high glucose‐induced its association...
AIM: To clarify this controversy and to provide evidence for application of lipid lowering agents in treatment diabetic retinopathy (DR). METHODS: We searched the databases PubMed, Embase Cochrane Library Central Register Controlled Trials (CENTRAL) abstracts from main annual meetings up January 1, 2017. Google scholar ClinicalTrials.gov were also unpublished relevant studies. included randomized controlled trials (RCTs) that studied lipid-lowering type 1 or 2 diabetes Meta-analysis. The...
Methylglyoxal (MGO), an active metabolite of glucose, has been reported to induce vascular cell apoptosis in diabetic complication. Polydatin (PD), a small natural compound from Polygonum cuspidatum, number biological functions, such as antioxidative, anti-inflammatory, and nephroprotective properties. However, the protective effects PD on MGO-induced endothelial cells remain be elucidated. In this study, human umbilical vein (HUVECs) were used explore possible mechanism involved. HUVECs...
AIM: To investigate the effects of quercetin on diabetic retinopathy (DR) and its association with nucleotide-binding oligomerization domain-like receptors 3 (NLRP3) inflammasome autophagy using retinal endothelial cell as an experimental model. METHODS: Human microvascular cells (HRMECs) were cultured in vitro assigned into control group, high-glucose (HG) HG+different concentrations groups. Cellular viability, migration, tube formation these groups was detected by MTT, transwell matrigel...
The role of growth factors and inflammation in regulating retinal pigment epithelial (RPE) function is complex still poorly understood. present study investigated human RPE cell proliferation migration mediated by platelet-derived factor (PDGF) inflammatory cytokines.Human fetal (hfRPE) cells were obtained as previously described. Gene expressions PDGF isoforms their receptors detected using real-time PCR. Protein expression, activity, localization PDGFR-alpha -beta analyzed Western blot...
To compare apelin-13, a ligand of G-protein-coupled receptor which has been shown to be involved in retinal angiogenesis, and vascular endothelial growth factor (VEGF) serum levels type 2 diabetes mellitus (T2DM) with or without retinopathy, investigate the relationship between concentration apelin-13 retinopathy.Sixty-nine patients T2DM were enrolled. Of 69 patients, 16 had proliferative diabetic retinopathy (PDR group), 23 non-PDR (NPDR group) 30 no (T2DM group). Subjects' information,...
Rosmarinic acid (RA) is a natural polyphenol with various biological activities, such as anti-oxidative, anti-fibrotic, and hepatoprotective properties. The objective of this study was to investigate the protective effect RA against acetaminophen (APAP)-induced hepatotoxicity (AILI) explore underlying mechanisms. Kunming mice were treated (20, 40, or 80 mg/kg, i.g) for 7d, followed by an intraperitoneal injection APAP (500 mg/kg). liver injury evaluated serum biochemical histopathological...
Sepsis-associated acute kidney injury (AKI) is a serious clinical problem without effective drugs. Inhibition of sirtuin 5 (SIRT5) has been confirmed to protect against AKI, suggesting that SIRT5 inhibitors might be promising therapeutic approach for AKI. Herein, structural optimization was performed on our previous compound 1 (IC50 = 3.0 μM), and series 2,4,5-trisubstituted pyrimidine derivatives have synthesized. The structure-activity relationship (SAR) analysis led the discovery three...
We have demonstrated that the retinoblastoma gene product (Rb) can positively regulate transcription from fourth promoter of insulinlike growth factor II gene. Two copies a motif (the control element) similar to found in human c-fos, transforming beta 1, and c-myc promoters are responsible for conferring Rb regulation shown Sp1 bind stimulate element motif. Moreover, by using GAL4-Sp1 fusion protein, we directly regulates transcriptional activity vivo. These results indicate function as...
To compare serum levels of chemerin in type 2 diabetes mellitus (T2DM) with or without retinopathy, and to investigate the relationship between retinopathy. A total 60 T2DM patients 20 healthy subjects (control group) were enrolled this study. Of patients, 15 had proliferative diabetic retinopathy (PDR group), non-proliferative (NPDR 25 no (T2DM group). Their samples collected for testing chemerin, vascular endothelial growth factor (VEGF), C-reactive protein (CRP) so on. The values analyzed...
Aims: To investigate the loss of retinal nerve fiber layer (RNFL) in type-2 diabetic patients with early-stage retinopathy (DR) and to identify potential risk factors accounting for these alterations.Methods: In this cross-sectional study, 158 were divided into three groups based on their DR status. RNFL thickness other optic disc parameters obtained by optical coherence tomography (OCT) then compared among different groups. We investigated association between systemic DR, including diabetes...
Recent studies highlight the vital role of oxidative stress and reactive oxygen species (ROS) during progression osteoarthritis (OA). Attenuating reducing generation in joints represent reasonable strategies for treatment osteoarthritis. To address potential question clinical translation, improve biocompatibility long-term performance current antioxidants, present study provided high biocompatible small positively charged tantalum nanoparticles (Ta-NH2 NPs) with sustained intra-articular...
Neural stem cell-derived extracellular vesicles (NSC-EVs) mediated endogenous neurogenesis determines a crucial impact on spontaneous recovery after stroke. Here, we checked the influence of Lycium barbarum polysaccharide (LBP) biogenesis NSC-EVs and then focused studying mechanisms LBP in ameliorating ischemic stroke outcome.LBP was prepared to precondition NSCs isolate EVs. MCAO models primary were administrated evaluate therapeutic effect. RT-PCR, western blot, flow cytometry,...
Abstract Diabetic retinopathy (DR) is a common diabetic complication known to cause vision impairment and blindness. Previous studies have demonstrated that proanthocyanidins (PACs), polyphenols are naturally found in several plants fruits, powerful antioxidant anti‐inflammatory effects on various cells. However, the underlying mechanism of PACs against DR pathogenesis remain unknown. Here, we investigated proliferation, apoptosis, mechanisms ARPE‐19 cells response oxidative stress...
Abstract Abnormal development of immature retinal vascular structure in preterm infants under the condition hyperoxia is primary cause retinopathy prematurity (ROP), which has become leading blindness children. Retinal ganglion cells (RGCs) play a critical role normal growth vessels. Previous studies have indicated that estrogen can alleviate lesions ROP animal model by inhibiting reactive oxygen species, associated with endoplasmic reticulum (ER) stress. This study aimed to investigate...
The damage of hyperglycemia to the retinal pigment epithelial (RPE) cells is a critical event in diabetic retinopathy (DR). Procyanidin (PC), kind polyphenol compounds, has shown be effective preventing and treating diabetes as well its complications, which autophagy disorder involved pathological mechanism. However, it remains unclear whether PC can play protective role DR by regulating RPE. Here, effect on RPE under high glucose conditions were investigated.The cell viability ARPE-19,...
To investigate the effect of ghrelin, a brain-gut peptide hormone, on high glucose-induced retinal angiogenesis in vitro and explore its association with endoplasmic reticulum (ER) stress.Human microvascular endothelial cells (HRMECs) were first divided into control high-glucose groups, mRNA protein expression levels receptor for ghrelin [growth hormone secretin 1a, (GHSR-1a)] determined. HRMECs then treated glucose alone or combination siGHSR-1a, cell viability, migration, tube formation ER...