A5100420560- Osteoarthritis Treatment and Mechanisms
- Silk-based biomaterials and applications
- Cellular Mechanics and Interactions
- Total Knee Arthroplasty Outcomes
- Tendon Structure and Treatment
- Liver Disease Diagnosis and Treatment
- Inflammatory mediators and NSAID effects
- Knee injuries and reconstruction techniques
- 3D Printing in Biomedical Research
- Nanoplatforms for cancer theranostics
- Cell Adhesion Molecules Research
- Electrospun Nanofibers in Biomedical Applications
- Orthopaedic implants and arthroplasty
- Bone Tissue Engineering Materials
- Lower Extremity Biomechanics and Pathologies
- Bone and Joint Diseases
- Hip disorders and treatments
- Diet, Metabolism, and Disease
- Periodontal Regeneration and Treatments
- Cancer-related molecular mechanisms research
- Tissue Engineering and Regenerative Medicine
- Hydrogels: synthesis, properties, applications
- Graphene and Nanomaterials Applications
- Wound Healing and Treatments
- Orthopedic Infections and Treatments
Southwest Medical University
2025
Chongqing Medical University
2020-2025
Shuguang Hospital
2017-2025
Shanghai University of Traditional Chinese Medicine
2017-2025
Chinese General Hospital College of Nursing and Liberal Arts
2013-2025
Chinese People's Liberation Army
2013-2025
Nanjing University of Posts and Telecommunications
2025
Nanjing Medical University
2024
Second Hospital of Anhui Medical University
2024
Anhui Medical University
2020-2024
Macrophages serve to maintain organ homeostasis in response challenges from injury, inflammation, malignancy, particulate exposure, or infection. Until now, receptor ligation has been understood as being the central mechanism that regulates macrophage function. Using macrophages of different origins and species, we report elasticity is a major determinant innate Macrophage modulated not only by classical biologic activators such LPS IFN-γ, but an equal extent substrate rigidity stretch....
Osteoarthritis (OA) is an age-related metabolic disease. Low-grade inflammation and oxidative stress are the last common pathway of OA. α-ketoglutarate (α-KG) essential physiological metabolite from mitochondrial tricarboxylic acid (TCA) cycle, with multiple functions, including anti-inflammation antioxidation, exhibits decreased serum levels age. Herein, we aimed to investigate effect mechanism α-KG on We first quantified in human cartilage tissue osteoarthritic chondrocytes induced by...
Cartilage tissue engineering is a promising approach for repairing and regenerating cartilage tissue. To date, attempts have been made to construct zonal that mimics the cartilaginous matrix in different zones. However, little attention has paid chondrocyte density gradient within articular cartilage. We hypothesized plays an important role forming distribution of extracellular (ECM).In this study, collagen type II hydrogel/chondrocyte constructs were fabricated using bioprinter. Three...
Abstract Methacrylated gelatin (GelMA)/bacterial cellulose (BC) composite hydrogels have been successfully prepared by immersing BC particles in GelMA solution followed photo-crosslinking. The morphology of GelMA/BC hydrogel was examined scanning electron microscopy and compared with pure GelMA. had very well interconnected porous network structure, the pore size decreased from 200 to 10 µm increase content. were also characterized swelling experiment, X-ray diffraction, thermogravimetric...
Cell senescence is a chronic process associated with age-related degenerative diseases such as osteoarthritis (OA). Senescent cells (SnCs) accumulate in the articular cartilage and synovium, leading to OA pathologies. The accumulation of SnCs results senescence-associated secretory phenotype (SASP) inflammation dysfunction. Selective removal by senolytic agent therapeutic strategy has been developed recently. In this study, we examined ability drug ABT263 (navitoclax) clear further evaluated...
Background High-intensity focused ultrasound (HIFU) has shown considerable promise in treating solid tumors, but its ultrasonic energy is easily attenuated, resulting insufficient accumulation the target area. Moreover, HIFU ablation alone may inevitably lead to presence of residual which cause tumor recurrence and metastasis. Here, we describe a synergistic regimen combining facilitation with immunomodulation based on novel oxygen-carrying biomimetic perfluorocarbon nanoparticle (M@P-SOP)...
Abstract The understanding of nanomaterial biology determines material selection and scaffold fabrication in regenerative medicine. translational application advanced functional nanomaterials, like graphene derivatives, requires an in‐depth investigation on the sophisticated material‐cell action network. To achieve therapeutic convergence between biocompatibility bioeffectiveness, herein, series derivatives are screened superiority oxide quantum dots (GOQDs) is confirmed. Thereby, a GOQD...
Cells resident in certain hollow organs are subjected routinely to large transient stretches, including every adherent cell lungs, heart, great vessels, gut, and bladder. We have shown recently that response a stretch the eukaryotic promptly fluidizes then gradually resolidifies, but mechanism is not yet understood.In isolated human bladder smooth muscle cell, here we applied 10% while measuring traction forces, elastic modulus, F-actin imaging F-actin/G-actin ratio. Immediately after...
Abstract Plant viral movement proteins (MPs) enable viruses to pass through cell walls by increasing the size exclusion limit (SEL) of plasmodesmata (PD). Here, we report that ability Cucumber mosaic virus (CMV) MP increase SEL PD could be inhibited treatment with actin filament (F-actin)–stabilizing agent phalloidin but not F-actin–destabilizing latrunculin A. In vitro studies showed CMV bound globular and F-actin, polymerization, severed participated in plus end capping F-actin. Analyses...
Cell source plays a key role in cell-based cartilage repair and regeneration. Recent efforts cell coculture have attempted to combine the advantages negate drawbacks of constituent types. The aim this study was evaluate chondrogenic outcome articular chondrocytes (ACs) infrapatellar fat pad (IPFP)-derived mesenchymal stem cells (MSCs) direct coculture. ACs IPFP MSCs from same patients with knee osteoarthritis (OA) were cocultured monolayer pellets. monocultures each type also used as...
The current methods of generating human cerebral organoids rely excessively on the use Matrigel or other external extracellular matrices (ECM) for cell micro-environmental modulation. embedding is problematic long-term culture and clinical applications due to high inconsistency limitations. In this study, we developed a novel microwell platform based 3D printing. This platform, without using signaling molecules (i.e., SMAD Wnt inhibitors), successfully generated matured with robust formation...
Background: Recruitment of endogenous stem cells has been considered an alternative to cell injection/implantation in articular cartilage repair. Purpose: (1) To develop a tissue-engineering scaffold with clinically available biomaterials and functionalize the aptamer (Apt19s) that specifically recognizes pluripotent cells. (2) determine whether this could recruit joint-resident mesenchymal (MSCs) when implanted into osteochondral defect rabbit model examine effects regeneration. Study...
Antitumor therapeutic vaccines are generally based on antigenic epitopes presented by major histocompatibility complex (MHC-I) molecules to induce tumor-specific CD8+ T cells. Paradoxically, continuous cell receptor (TCR) stimulation from tumor-derived T-cell can drive the functional exhaustion of Tumor-specific type-I helper CD4+ (TH1) cells play an important role in population maintenance and cytotoxic function exhausted tumor microenvironment. Nonetheless, whether vaccination strategy...
In the current study, a novel chitosan-based composite, carboxymethyl chitosan (CMCHS)/oxidized cellulose (OCMC) was fabricated and characterized. The composite film (CMCHS 1.5%w/v + OCMC 0.8%w/v) more uniform had better tensile properties, UV blocking, water vapor permeability, antifungal properties than pure CMCHS film. Preservation experiments showed that CMCHS/OCMC efficient for retaining quality decrease of strawberry during storage. By end 7 days' storage, hardness, contents organic...
Abstract Cuproptosis, a recently discovered copper‐dependent cell death, presents significant potential for the development of copper‐based nanoparticles to induce cuproptosis in cancer therapy. Herein, unique ternary heterojunction, denoted as HACT, composed core–shell Au@Cu 2 O nanocubes with surface‐deposited Titanium Dioxide quantum dots and modified hyaluronic acid is introduced. Compared AC NCs, TiO /Au@Cu exhibits improved energy structure optimization, successfully separating...