A5101902447- Inflammatory mediators and NSAID effects
- Osteoarthritis Treatment and Mechanisms
- Peroxisome Proliferator-Activated Receptors
- Bone Metabolism and Diseases
- Bone and Joint Diseases
- Advanced Glycation End Products research
- Estrogen and related hormone effects
- Cytokine Signaling Pathways and Interactions
Jishou University
2020-2024
Zhongnan Hospital of Wuhan University
2023
Wuhan University
2023
Hunan Normal University
2014-2020
Osteoarthritis (OA) is an age-related metabolic disease. Low-grade inflammation and oxidative stress are the last common pathway of OA. α-ketoglutarate (α-KG) essential physiological metabolite from mitochondrial tricarboxylic acid (TCA) cycle, with multiple functions, including anti-inflammation antioxidation, exhibits decreased serum levels age. Herein, we aimed to investigate effect mechanism α-KG on We first quantified in human cartilage tissue osteoarthritic chondrocytes induced by...
Objective Advances made in the past ten years highlight notion that peroxisome proliferator-activated receptors gamma (PPARγ) has protective properties pathophysiology of osteoarthritis (OA). The aim this study was to define roles PPARγ AGEs-induced inflammatory response human chondrocytes. Methods Primary chondrocytes were stimulated with AGEs presence or absence neutralizing antibody against RAGE (anti-RAGE), MAPK specific inhibitors and agonist pioglitazone. expression IL-1, MMP-13,...
Glucocorticoid-induced osteoporosis (GIOP) is the common reason for secondary osteoporosis. Dendrobine (DEN) major biologically active component of
Advanced glycation end products (AGEs) play a pivotal role in the initiation and progression of osteoarthritis (OA). Peroxisome proliferator-activated receptor-γ (PPARγ) has been shown to exhibit anti-inflammatory anticatabolic properties be protective animal models OA. This study was aimed investigate possible effect PPARγ agonist pioglitazone on AGE-induced chondrocyte damage.Cultured chondrocytes were stimulated with AGEs presence or absence an antibody against receptor for (anti-RAGE),...
Abstract Aims : There is a well-established link between OA and diabetes, study have shown that hyperglycemia might play an important role in the occurrence development of OA. Accumulative evidence suggested PPARγ was involved AGEs-related disease, including diabetes The designed to investigate effects on expression chondrocytes whether agonist pioglitazone had chondroprotective effect. Main methods Primary human were incubated with different concentration glucose medium(5.5mM-30mM) presence...