A5075524725- Cancer-related molecular mechanisms research
- Orthopaedic implants and arthroplasty
- Osteoarthritis Treatment and Mechanisms
- Total Knee Arthroplasty Outcomes
- RNA modifications and cancer
- Inflammatory mediators and NSAID effects
- MicroRNA in disease regulation
- Sarcoma Diagnosis and Treatment
- Hydrocarbon exploration and reservoir analysis
- Orthopedic Infections and Treatments
- Hip disorders and treatments
- Circular RNAs in diseases
- RNA Research and Splicing
- Bone and Joint Diseases
- COVID-19 Clinical Research Studies
- Oral Health Pathology and Treatment
- Knee injuries and reconstruction techniques
- Cytokine Signaling Pathways and Interactions
- Methane Hydrates and Related Phenomena
- Nutritional Studies and Diet
- Epigenetics and DNA Methylation
- Healthcare and Venom Research
- SARS-CoV-2 and COVID-19 Research
- Atmospheric and Environmental Gas Dynamics
- Long-Term Effects of COVID-19
Affiliated Hospital of Jiangxi University of Traditional Chinese Medicine
2022-2024
Jiangxi University of Traditional Chinese Medicine
2021-2024
Qingdao University
2021-2024
National Central University
2023-2024
Shanghai University of Engineering Science
2024
Dalian Maritime University
2023-2024
Ministry of Transport
2023-2024
Central South University
2014-2023
Second Xiangya Hospital of Central South University
2014-2023
Jinan Stomatological Hospital
2015-2023
Doxorubicin is the preferred chemotherapeuticdrug for osteosarcoma treatment of which clinical efficacy limited because its chemo-resistance and cardiac toxicity. It necessary to develop combination regimen with complementary molecular mechanisms reduce side effects enhance sensitivity Doxorubicin. EGCG a polyphenol in green tea antitumor bioactivity,which has been found that certain chemotherapeutic drugs could improve efficiency. In this study, MTT assay was used detect cell growth...
(-)-Epigallocatechin-3-gallate (EGCG), the most abundant and active polyphenol in green tea, has been demonstrated to have anticancer effects a wide variety of human cancer. MicroRNAs (miRNAs) are class short noncoding RNAs play important role gene regulation critically involved pathogenesis progression This study aims investigate EGCG on osteosarcoma (OS) cells elucidate underlying mechanism. Cellular function assays revealed that inhibited cell proliferation, induced cycle arrest promoted...
ABSTRACT Osteoarthritis (OA) is characterized by progressive destruction of articular cartilage, resulting in significant disability. Inflammatory cytokines commonly initiate the extreme changes synovium and cartilage microenvironment OA patients, subsequently cell dysfunctions, especially synoviocyte dysfunction. We revealed that expression osteopontin (OPN), which has been reported to regulate various inflammatory factors associating with pathogenesis including matrix metalloprotease 13...
The pain and fear caused by direct local injection of anesthetic or the poor experience with surface cream increase difficulty clinical treatment for oral diseases. To address this problem, a hyaluronic acid microneedle patch (Li-HAMNs) that consists fast-dissolving lidocaine hydrochloride (LDC)-loaded tips wet-adhesive backing layer made polyvinyl alcohol (PVA)/carboxymethylcellulose sodium (CMC-Na) was fabricated to explore its potential use in dental topical anesthesia. Li-HAMNs could...
Skin wound caused by external injury is usually difficult to be cured conventional topical administration because of its poor drug diffusion across the stratum corneum. It has been recognized that corneum major obstacle for transdermal delivery. To address this issue, microneedles (MNs) have developed penetrate skin and then form micron-sized pores between epidermis dermis layers. As such, biomacromolecule drugs and/or insoluble molecules can allowed effective penetration. A multifunctional...
Abstract Personalized news recommendation is an important technology to help users obtain information they are interested in and alleviate overload. In recent years, has been increasingly widely studied achieved remarkable success improving the reading experience of users. this paper, we provide a comprehensive overview personalized approaches. Firstly, introduce systems according different needs analyze characteristics. And then, three-part research framework on put forward. Based...
Bone homeostasis and resorption is regulated by the proper activation of osteoclasts, whose stimulation largely depends on receptor activator nuclear factor κB ligand (RANKL)-RANK signaling. Herein, for first time, we showed that interferon regulatory (Irf)-3 was intimately involved in RANKL-induced osteoclast formation. In addition, hesperetin (Hes) derived from citrus fruit could inhibit differentiation maturation among three types precursors with inhibited formation F-actin rings pits...
Doxorubicin (Dox) is one of the most commonly used chemotherapeutic drugs for osteosarcoma (OS) treatment. In present study, we attempted to investigate mechanism by which Sox2OT-V7 dysregulation affects Dox chemoresistance provide a novel experimental basis developing neoadjuvant therapy. expression upregulated in OS tissues, particularly chemoresistant and cell lines compared controls. treatment induces autophagy U2OS cells, Dox-induced partially attenuated silencing. Knocking down or...
Oral mucositis (OM) is the most common disease of oral mucosa, which affects people’s daily production and life. Triamcinolone ointment clinical drug for OM treatment. However, hydrophobic properties triamcinolone acetonide (TA) complex microenvironment cavity led to its low bioavailability unstable therapeutic effects on ulcer wounds. Herein, dissolving microneedle patches (MNs) composed mesoporous polydopamine nanoparticles (MPDA) loaded with TA (TA@MPDA), sodium hyaluronic acid (HA),...
Aims: Accumulation of advanced glycation end products (AGEs) plays a pivotal role in the mechanism by which aging contributes to osteoarthritis (OA). In present study, we examined effect curcumin, pharmacologically safe phytochemical agent, on AGE-induced tumor necrosis factor-α (TNF-α) and matrix metalloproteinase-13 (MMP-13) rabbit chondrocytes. Methods: Chondrocytes were derived from articular cartilage enzymatic digestion. TNF-α MMP-13 mRNA was monitored RT-PCR. protein determined using...
The aim of this study is to investigate the role tumor necrosis factor-α (TNF-α) in apoptosis and autophagy mouse osteoblast MC3T3-E1 cells, as well crosstalk between apoptosis. Mouse cells were cultured vitro treated with 5-fluorouracil (5-FU), rapamycin, 3-methyl adenine (3-MA) TNF-α either alone or combination, respectively. MTT assays used monitor cell viability upon different treatments. Annexin-V-FITC/propidium iodide (PI) staining was detect apoptotic rate osteoblasts. Autophagic...
The chemical components, He, Ne, and C isotropic ratios of gas samples collected thrice from 32 hot springs in western Sichuan Province, southwestern China June October 2008 2009 were investigated order to discuss the relationship between spring geochemistry Wenchuan Ms 8.0 earthquake.The data showed that 3 He/ 4 He C13 CO2 d values gases Longmenshan fault (LMSF), Xianshuihe (XSHF), Minjiang (MJF) zones increased obviously after great earthquake.It was estimated up 62% mantle helium...