A5068164845- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Shoulder Injury and Treatment
- Orthopaedic implants and arthroplasty
- Knee injuries and reconstruction techniques
- COVID-19 Clinical Research Studies
- Tendon Structure and Treatment
- Sports injuries and prevention
- Total Knee Arthroplasty Outcomes
- Shoulder and Clavicle Injuries
- Cancer-related molecular mechanisms research
- Orthopedic Surgery and Rehabilitation
- MicroRNA in disease regulation
- Crystallography and molecular interactions
- Cytokine Signaling Pathways and Interactions
- Orthopedic Infections and Treatments
- Long-Term Effects of COVID-19
- Osteoarthritis Treatment and Mechanisms
- Lower Extremity Biomechanics and Pathologies
- Bone Tissue Engineering Materials
- Extracellular vesicles in disease
- Nerve Injury and Rehabilitation
- Titanium Alloys Microstructure and Properties
- Spine and Intervertebral Disc Pathology
- Foot and Ankle Surgery
Second Xiangya Hospital of Central South University
2016-2025
Central South University
2016-2025
Chenzhou First People's Hospital
2018-2024
Mayo Clinic
2024
Pudong New Area People's Hospital
2011-2023
Tongji Hospital
2010-2022
Huazhong University of Science and Technology
2022
Hangzhou First People's Hospital
2018-2020
Zhejiang University
2020
Stanford University
2019
Asymptomatic and symptomatic patients may transmit severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), but their clinical features immune responses remain largely unclear. We aimed to characterise the of asymptomatic infected with SARS-CoV-2.We collected clinical, laboratory epidemiological records hospitalised in a field hospital Wuhan. performed qualitative detection anti-SARS-CoV-2 immunoglobulin M (IgM) G (IgG) using archived blood samples.Of 214 SARS-CoV-2, 26 (12%) were at...
Osteoblastic lineage cells are commonly used to evaluate the in vitro osteogenic ability of bone biomaterials. However, contradictory results obtained from vivo and studies not uncommon. With increasing understanding osteoimmunology, immune response has been recognized as playing an important role regeneration. In this study, we examined effect submicron-scaled titanium surface roughness (ranging approximately 100 400 nm) on osteoblasts macrophages. The showed that osteoblast differentiation...
Temporary COVID-19 specialty hospitals proved to be useful in the control of an infectious crisis a large epicenter, and hopefully this approach provides blueprint for management future epidemics or pandemics.
Abstract Rotator cuff tear is one of the most common musculoskeletal disorders, which often results in recurrent shoulder pain and limited movement. Enthesis a structurally complex functionally critical interface connecting tendon bone that plays an essential role maintaining integrity joint. Despite availability advanced surgical procedures for rotator repair, there high rate failure following surgery due to suboptimal enthesis healing regeneration. Novel strategies based on tissue...
Doxorubicin (Dox) is one of the most commonly used chemotherapeutic drugs for osteosarcoma (OS) treatment. In present study, we attempted to investigate mechanism by which Sox2OT-V7 dysregulation affects Dox chemoresistance provide a novel experimental basis developing neoadjuvant therapy. expression upregulated in OS tissues, particularly chemoresistant and cell lines compared controls. treatment induces autophagy U2OS cells, Dox-induced partially attenuated silencing. Knocking down or...
Osteosarcoma is the most common primary bone malignancy. Recently, studies showed chemokine receptor 4 ( CXCR 4) played a critical role in osteosarcoma. However, regulation of not fully understood. micro RNA s are short, non‐coding that play an important roles post‐transcriptional gene expression variety diseases including miR‐613 newly discovered mi and has been reported to function as tumor suppressor many cancers. In this study, we confirmed both Stromal Cell‐Derived Factor SDF ‐1) could...
Coronavirus disease 2019 (COVID-19) can result in an endothelial dysfunction acute phase. However, information on the late vascular consequences of COVID-19 is limited.Brachial artery flow-mediated dilation (FMD) examination were performed, and inflammatory biomarkers assessed 86 survivors for 327 days (IQR 318-337 days) after recovery. Comparisons made with 28 age-matched sex-matched healthy controls 30 risk factor-matched patients.Brachial FMD was significantly lower than [median (IQR) 7.7...
Background: Posterior cruciate ligament (PCL) injury is a relatively common musculoskeletal condition. However, there currently lack of consensus on decision-making, treatment and postoperative management for such injuries. Objectives: To use the modified Delphi method to reach expert PCL injury. Methods: A literature search PubMed, Cochrane Library, Embase, Web Science articles up 17 October 2024, support development recommendation statements. An Expert Panel 90 experienced clinicians from...
Accumulating evidence indicated that inhibiting the expression of a disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS)-5 ameliorate cartilage degradation, suggesting ADAMTS-5 as an effective target for treating osteoarthritis (OA). A recent study has identified long noncoding RNA (lncRNA) HOTAIR most up-regulated lncRNA upregulated gene, respectively, in human OA compared normal cartilage. In present study, we explored regulatory effect on well underlying mechanisms...
Background . Information regarding the impact of cardiovascular (CV) conditions on disease progression among patients with mild coronavirus 2019 (COVID-19) is limited. Methods This study evaluated association underlying CV in COVID-19. The primary outcome was need to be transferred designated hospital for intensive care due COVID-19 progression. were divided into and without as well stable groups. Results Of 332 COVID-19, median age 51 years (IQR, 40-59 years), 200 (61.2%) female. 48 (14.5%)...
We aimed to identify factors that affect pain, complications, and function following elbow arthroscopy for synovial chondromatosis.We retrospectively reviewed the cases of all patients with chondromatosis treated by arthroscopic synovectomy loose body removal between January 2000 2016 at our institution. Eleven were enrolled (8 male; mean age, 41.7 years). The duration symptoms was 13.7 months, had a decreased range motion (ROM) in affected elbow. By Milgram criteria, there 1 phase II case,...
Objective: Cyclin D1 was an important molecular involved in the pathological process of osteoarthritis (OA). The purpose this study to identify effect and potential mechanism for proliferation apoptosis OA chondrocytes. Methods: We used polymerase chain reaction (PCR) method expression levels down-stream Wnt/β-catenin pathway-related genes chondrocytes according grade OA. Small interfering RNA (siRNA) or overexpression were role cell apoptosis. Next, we XAV-939 inhibit pathway explore...
Three dimensional finite element models of cam-type FAI with alpha angles 60°, 70°, 80°, and 90° were created to investigate the cartilage contact mechanics in daily activities. Intra-articular pressures during routine activities assessed cross-compared a normal control hip. Alpha hip range motion found have combined influence on hips FAI, thereby resulting abnormally high driving damage. In particular, 80° or greater contribute substantial pressure increase under certain types
Rheumatoid arthritis (RA) is a common chronic autoimmune disease and effective treatment for RA still lacking. In this study, the regulatory role of miR-19a-3p in was investigated. Quantitative polymerase chain reaction analysis human blood samples showed that level significantly lower patients compared with healthy (P < 0.05). fibroblast-like synoviocytes (RAFLS), suppressor cytokine signaling 3 (SOCS3) were also downregulated upregulated, respectively, those normal FLS. Transfection mimic...
Cisplatin is an effective chemotherapeutic agent for osteosarcoma (OS) and has been shown to induce endoplasmic reticulum (ER) stress-associated apoptosis in human cancer cells. Ganglioside GD2-specific antibodies can inhibit tumor cell viability without involvement of the immune system. A recent study that antiGD2 monoclonal antibody (mAb) 14G2a effectively inhibits invasiveness OS In this study, we explored effect anti-GD2 mAb cisplatin alone combination on ER MG-63 Saos-2 cells were...
Natural medicines plants are significant considerable attention as potential therapeutic agents for bone tissue engineering. Cissus quadrangularis L (CQ). is a potent plant known its own osteogenic properties. In this research work, phytoconstituents-filled composite was produced by incorporating CQ extract with gelatin (Gel) and pectin (Pec) polymers collective through β- tricalcium phosphate (β-TCP) bioceramic via green template method. The effect of CQ-filled morphology chemical...