A5048383353- COVID-19 Clinical Research Studies
- Retinal Diseases and Treatments
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Cardiovascular Function and Risk Factors
- Cancer-related molecular mechanisms research
- Sepsis Diagnosis and Treatment
- Immune cells in cancer
- Long-Term Effects of COVID-19
- SARS-CoV-2 and COVID-19 Research
- Ion channel regulation and function
- CAR-T cell therapy research
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Heart Failure Treatment and Management
- Liver Disease Diagnosis and Treatment
- Immune Cell Function and Interaction
- Chronic Obstructive Pulmonary Disease (COPD) Research
- RNA modifications and cancer
- Ubiquitin and proteasome pathways
- Autophagy in Disease and Therapy
- Circular RNAs in diseases
- Protein Degradation and Inhibitors
- Phagocytosis and Immune Regulation
- Disaster Response and Management
- Emergency and Acute Care Studies
- Advanced Glycation End Products research
First Affiliated Hospital of Henan University of Science and Technology
2023-2025
Lishui City People's Hospital
2025
Southeast University
2025
Qingdao University
2016-2024
Affiliated Hospital of Qingdao University
2016-2024
Northeast Agricultural University
2024
Xijing Hospital
2017-2024
Air Force Medical University
2017-2024
Shandong First Medical University
2023-2024
North China University of Technology
2024
Abstract Background The National Early Warning Score (NEWS2) is currently recommended in the UK for risk stratification of COVID-19 patients, but little known about its ability to detect severe cases. We aimed evaluate NEWS2 prediction outcome and identify validate a set blood physiological parameters routinely collected at hospital admission improve upon use alone medium-term stratification. Methods Training cohorts comprised 1276 patients admitted King’s College Hospital Health Service...
The dysregulation of CD3 + CD8 T lymphocytes, CD16 CD56 NK cells, C1q as well IL-6, along with bacterial coinfection, were important causes exacerbation the patients’ condition and death.
Abstract Background Previous studies reported the prognostic value of atherogenic index plasma (AIP) in course atherosclerosis and other cardiovascular diseases (CVDs). Still, predictive utility AIP is unknown among patients with type 2 diabetes mellitus (T2DM). Methods This was a secondary analysis Action to Control Cardiovascular Risk Diabetes (ACCORD) study, which randomized 10,251 long-lasting T2DM. ROC curve used determine an optimal threshold for AIP, study population divided into high...
Abstract Acute respiratory distress syndrome (ARDS) is a common critical with no effective therapeutic intervention. Neutrophils function in the overwhelming inflammatory process of acute lung injury (ALI) caused by ARDS; however, phenotypic heterogeneity pulmonary neutrophils ALI/ARDS remains largely unknown. Here, using single-cell RNA sequencing, we identify two transcriptionally and functionally heterogeneous neutrophil populations (Fth1 hi Neu Prok2 Neu) distinct locations LPS-induced...
OBJECTIVE Remnant cholesterol (remnant-C) predicts atherosclerotic cardiovascular disease, regardless of LDL-cholesterol (LDL-C) levels. This study assessed the associations between remnant-C and outcomes in type 2 diabetes. RESEARCH DESIGN AND METHODS post hoc analysis Action to Control Cardiovascular Risk Diabetes (ACCORD) trial used patient (type diabetes >3 months) major adverse event (MACE) data from database. The MACEs were evaluated using Cox proportional hazards regression...
Lung cancer is the leading cause of cancer-related mortality globally. Discovering effective biomarkers for early diagnosis and prognosis important to reduce rate ensure efficient therapy lung patients. C-type lectin domain family 3 member B (CLEC3B) has been reported in various cancers, but its correlation with remains elusive.The GEO, TCGA Oncomine databases were analyzed examine expression CLEC3B cancer. The mRNA levels 15 patient tissue samples detected by real-time PCR protein 34...
Abstract Acute lung injury (ALI)/acute respiratory distress syndrome (ARDS) is a common critical that currently has no effective therapeutic interventions. Pulmonary macrophages play principal role in the initiation and progression of overwhelming inflammation ALI/ARDS. Here, type fluorous‐tagged bioactive peptide nanoparticle termed CFF13F developed, which can be efficiently internalized by suppress excessive expression cytokines overproduction reactive oxygen species (ROS) triggered...
Drip fertigation is an advanced technology combining micro-irrigation with fertilization, which conducive to deliver water and nutrients crops or fruit trees synchronously. To optimize drip scheduling for wine grape in North China, a three-year field experiment was conducted study the effects of irrigation fertilization quota on yield, berry quality, use efficiency (WUE) partial factor productivity fertilizer (PFPF). Nine treatments were set up based combinations three levels rates. The 100...
Ocular neovascularization is a comprehensive process involved in retinal vascular development and several blinding diseases such as age-related macular degeneration retinopathy of prematurity, with endothelial growth factor (VEGF) regarded the master regulator. However, qualified effect anti-VEGF therapy reveals that underlying mechanisms are still not clearly identified. To initialize angiogenesis, cells undergo phenotype switching to generate highly migratory invasive cells. This shares...
Abstract Background The National Early Warning Score (NEWS2) is currently recommended in the United Kingdom for risk stratification of COVID outcomes, but little known about its ability to detect severe cases. We aimed evaluate NEWS2 outcome and identify validate a set routinely-collected blood physiological parameters taken at hospital admission improve score. Methods Training cohorts comprised 1276 patients admitted King’s College Hospital NHS Foundation Trust with COVID-19 disease from 1...
Vascular smooth muscle cell (VSMC) senescence in the vasculature results vascular aging as well age-related diseases, while metformin improves inflamm-aging profile by enhancing autophagy. However, metformin's impact on VSMC is largely undefined. To test hypothesis that exerts an anti-senescence role restoring autophagic activity VSMCs and tissues. Animal models established angiotensin II (Ang II) induction physiological senescent primary from aortas of elderly patients were treated with...
Abstract Microglia were considered as immune cells in inflammation until their angiogenic role was widely understood. Although the pro-inflammatory of microglia retinal angiogenesis has been explored, little is known about its pro-angiogenesis and microglia–endothelia interaction. Here, we report that galectin-3 (Gal3) released by activated functions a communicator between endothelia competitively binds to Jag1, thus inhibiting Notch signaling pathway enhancing endothelial metabolism promote...
Traditional Chinese medicine (TCM) has shown potential in the treatment of cancer. This study investigated molecular targets and mechanisms Coptis chinensis cervical cancer using network pharmacology bioinformatics. Effective components were screened from Medicine Systems Pharmacology (TCMSP) platform based on following criteria: drug-like properties (DLP) ≥0.18 oral bioavailability (OB) ≥30%. Target genes identified through DrugBank, while differentially expressed (DEGs) related to sourced...
The microbiota-gut-brain axis plays a pivotal role in neuropsychiatric disorders, particularly depression. Escitalopram (ESC) is first-line antidepressant, however, its regulatory mechanisms on the treatment of depression remain unclear. antidepressant effects ESC were evaluated using forced swim test Wistar-Kyoto (WKY) rats, while damage gut and brain regions was assessed through H&E staining immunohistochemistry. therapeutic WKY rats with depression-like behavior investigated 16S rRNA...
Novel diagnostic predictors and drug targets are needed for LUAD (lung adenocarcinoma). We aimed to build a specific SVM (support vector machine) classifier diagnosis of identify molecular markers with prognostic value LUAD.The expression differences miRNAs, lncRNAs mRNAs between normal samples were compared using data from TCGA (The Cancer Genome Atlas) database. A related miRNA-lncRNA-mRNA network was constructed, based on which feature genes selected the construction classifier. The...
Abstract Lung cancer has the highest morbidity and mortality among all cancers. Discovery of early diagnostic prognostic biomarkers lung can greatly facilitate survival rate reduce its mortality. In our study, by analyzing Gene Expression Omnibus Oncomine databases, we found a novel potential oncogene uridine‐cytidine kinase 2 ( UCK ), which was overexpressed in tumor tissues compared to adjacent nontumor or normal lung. Then confirmed this finding clinical samples. Specifically, identified...
Abstract Background Accurate risk prediction of clinical outcome would usefully inform decisions and intervention targeting in COVID-19. The aim this study was to derive validate models for poor death adult inpatients with Methods Model derivation using data from Wuhan, China used logistic regression (death or severe disease) as outcomes. Predictors were demographic, comorbidity, symptom laboratory test variables. best performing externally validated London, UK. Findings 4.3% the cohort...