A5002130793- Mathematics Education and Programs
- Cosmology and Gravitation Theories
- Black Holes and Theoretical Physics
- Quantum Electrodynamics and Casimir Effect
- Education Systems and Policy
- Data-Driven Disease Surveillance
- COVID-19 Clinical Research Studies
- Hemoglobinopathies and Related Disorders
- Disaster Response and Management
- Renal Transplantation Outcomes and Treatments
- Emergency and Acute Care Studies
- Dialysis and Renal Disease Management
- Erythropoietin and Anemia Treatment
- Iron Metabolism and Disorders
- Engineering Education and Curriculum Development
- Pharmacological Effects and Toxicity Studies
- Blood groups and transfusion
- Mathematics Education and Teaching Techniques
- Sepsis Diagnosis and Treatment
- Acute Kidney Injury Research
- Respiratory Support and Mechanisms
- Antibiotics Pharmacokinetics and Efficacy
- Healthcare cost, quality, practices
- Health Literacy and Information Accessibility
- Organ Donation and Transplantation
Technological University Dublin
2015-2025
University of Trieste
2023
Institute for Fundamental Physics of the Universe
2023
Scuola Internazionale Superiore di Studi Avanzati
2023
Istituto Nazionale di Fisica Nucleare, Sezione di Trieste
2023
Guy's and St Thomas' NHS Foundation Trust
2009-2022
Dublin City University
2017-2022
King's College London
2020-2021
St Thomas' Hospital
2012-2021
Hershey (United States)
2020
Abstract. Novel erythropoiesis stimulating protein (NESP) is a hyperglycosylated analogue of recombinant human erythropoietin (Epoetin) which has an increased terminal half-life in animal models. The aim this study was to extend these observations humans. Using double-blind, randomized, cross-over design, the single-dose pharmacokinetics Epoetin alfa (100 U/kg) and equivalent peptide mass NESP were compared following intravenous bolus 11 stable peritoneal dialysis patients. This followed by...
Abstract Background The National Early Warning Score (NEWS2) is currently recommended in the UK for risk stratification of COVID-19 patients, but little known about its ability to detect severe cases. We aimed evaluate NEWS2 prediction outcome and identify validate a set blood physiological parameters routinely collected at hospital admission improve upon use alone medium-term stratification. Methods Training cohorts comprised 1276 patients admitted King’s College Hospital Health Service...
Patients admitted to hospital with Covid-19 are at risk of deterioration. The National Early Warning Score (NEWS2) is widely recommended, however it's validity in not established and indices more specific for respiratory failure may be appropriate. We aim describe the physiological antecedents deterioration, test predictive NEWS2 compare this ROX index ([SpO
The basis for the management of advanced chronic kidney disease is seamless integration renal replacement therapy (HD, peritoneal dialysis, and transplantation) with evidence based medical treatment its complications. National Service Framework Part 1: Dialysis Transplantation has stressed need a patient-centred approach in planning provision an emphasis on patient education choice as well adequate resources elective access surgery, dialysis transplantation [1]. It also identified that small...
Abstract Background The National Early Warning Score (NEWS2) is currently recommended in the United Kingdom for risk stratification of COVID outcomes, but little known about its ability to detect severe cases. We aimed evaluate NEWS2 outcome and identify validate a set routinely-collected blood physiological parameters taken at hospital admission improve score. Methods Training cohorts comprised 1276 patients admitted King’s College Hospital NHS Foundation Trust with COVID-19 disease from 1...
We present a new mode-sum prescription for the efficient computation of renormalized expectation values massive, charged, quantum scalar field propagating on curved space-time background. Our method is applicable to any static, spherically symmetric, four-dimensional with time-independent, background electrostatic potential and can be used find condensate, current stress-energy tensor. As an explicit example, we calculation these quantities charged in Hartle-Hawking state Reissner-Nordström...
Cardiovascular Disease in CKD 1. disease (CVD) (Guidelines CVD 1.1-1.8)Guideline 1.1 -CVD: risk factorsWe recommend that a history of and factors for cardiovascular patients with stage 1-5 dialysis should be recorded format permits audit the management such (1B).These include:. Angina myocardial infarction .Previous coronary angioplasty or artery bypass grafting .Stroke transient ischaemic attack carotid surgery .Peripheral vascular previous intervention .Cardiac failure .Arrhythmias...
Coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and carries a fatality rate of 1.0% to 13.5% in confirmed cases.1Verity R. Okell L.C. Ddorigatti I. et al Estimates the severity 2019: model-based analysis.Lancet Infect Dis. 2020; 20: 669-677Abstract Full Text PDF PubMed Scopus (2298) Google Scholar,2Johns Hopkins University Center for Systems Science Engineering (JHU CSSE)COVID-19 Data Repository (CSSE) at Johns...
This paper presents a new approach to computing the vacuum polarization of scalar field in static, spherically symmetric backgrounds odd dimensions. The novel is expanding two point function Fourier modes, thereby enabling mode by subtraction infinities and rapid convergence series.
Many studies over the past 30 years have highlighted important role of students' beliefs for successful problem-solving in mathematics. Given recent emphasis afforded to on reformed Irish secondary school mathematics curriculum, main aim this study was identify (n = 975) about field. A quantitative measure these attained through use Indiana Mathematical Belief Scale, an existing 30-item (five-scale) self-report questionnaire. statistical analysis data revealed that students who were further...
In this paper, we describe an extremely efficient method for computing the renormalized stress-energy tensor of a quantum scalar field in spherically symmetric black hole spacetimes. The applies to with arbitrary parameters. We demonstrate utility by Schwarzschild spacetime, applying our results discuss null energy condition and semiclassical backreaction.
We present a mode-sum regularization prescription for computing the vacuum polarization of scalar field in static spherically symmetric black hole spacetimes even dimensions. This is first general and systematic approach to regularized higher dimensions, building upon previous scheme we developed odd Things are more complicated here since even-dimensional propagator possesses logarithmic singularities which must be regularized. However, spite this complication, parameters can computed closed...
We consider a quantum field which is in Hartle-Hawking state propagating spherically symmetric black hole space-time. calculate the components of stress tensor, renormalized using Hadamard form Green's function, exterior region this then specialize these results to case `lukewarm' Riessner-Nordstrom-de Sitter hole.
We consider a quantum field on lukewarm black hole spacetime. introduce new uniform approximation to the radial equation, constructed using an extension of Green-Liouville asymptotics. then use this construct renormalized vacuum polarization in Hartle-Hawking vacuum. Previous calculations rely WKB solutions however nonuniformity approximations obscures results these near both horizons. The our eliminates obscurities, enabling us obtain explicitly finite and easily calculable values two
There are over 12,000 people with sickle cell disease (SCD) in the UK, and 4–12% of patients who develop Sickle Cell Nephropathy (SCN) progress to End Stage Renal Disease (ESRD). transplantation offers best outcomes for these but their access is often limited. Regular automated exchange blood transfusions (EBT) reduce complications SCD may improve outcomes. However, concerns alloimmunisation limit its widespread implementation. In this retrospective multicenter study, data were collected on...
In 2010 a mathematics curriculum was introduced in Irish second level schools entitled 'Project Maths' (PM). It aimed to refocus teaching and learning away from an over emphasis on procedural towards problem solving real understanding [Department of Education Skills (DES). (2010). Report the Project Maths implementation support group. https://www.education.ie/en/Publications/Policy-Reports/Report-of-the-Project-Maths-Implementation-Group.pdf]. This paper aims examine performance 1st year...
In this paper, we consider a quantum scalar field propagating on the Reissner-Nordstr\"om black hole spacetime. We compute renormalized stress-energy tensor for in Hartle-Hawking, Boulware and Unruh states. When is Hartle-Hawking state, renormalize using recently developed ``extended coordinate'' prescription. This method, which relies Euclidean techniques, very fast accurate. Once, have states by leveraging fact that difference between tensors different already finite. range of coupling...
We consider a quantum field which is in Hartle-Hawking state propagating general spherically symmetric black hole space-time. make use of uniform approximations to the radial equation calculate components stress tensor, renormalized using Hadamard form Green's function, on horizons this then specialize these results case `lukewarm' Reissner-Nordstrom-de Sitter and derive some conditions tensor for regularity state.
This article details an initial analysis of the transition a second level curriculum reform to higher education in Ireland. The entitled ‘Project Maths’ involved changes what students learn mathematics, how they it, and are assessed. Changes were rolled out nationally on phased basis September 2010. Students who taught assessed through new first entered third 2012. It is important that mathematics lecturers aware since certain topics such as vectors matrices no longer at level. Hence,...
Most patients with kidney failure receive hemodialysis 3 times per week in a facility. More frequent and longer duration dialysis prescriptions improve number of key outcome measures. These are best suited to self-care home regimens. The Quanta SC+ system is novel device demonstrated ease use for health care practitioners through human factors testing. primary objective this study report the efficacy safety using conventional prescriptions.Nonrandomized observational study.Prevalent 4 sites...
Rosamund Tibbles and colleagues describe the implementation of a hospital-based haemodialysis self-care patient education programme
We compute the renormalized expectation value of square a massless, conformally coupled, quantum scalar field on brane higher-dimensional black hole. Working in AADD brane-world scenario, extra dimensions are flat and we assume that compactification radius is large compared with size The four-dimensional on-brane metric corresponds to slice through Schwarzschild-Tangherlini hole geometry depends number bulk space-time dimensions. thermal state at Hawking temperature. An exact, closed-form...
Journal Article Investigating the engagement of mature students with mathematics learning support Get access Cormac Breen, Breen * †Dublin Institute Technology, Dublin, Ireland and ‡Trinity College is coordinator Mathematics Learning Support Centre (MLSC) in Dublin Technology (DIT). He holds a degree masters Theoretical Physics from University (UCD) completed his PhD Physics, also UCD, 2011. has lectured tutored both UCD DIT, been MLSC since May 2013. conducts research areas Education...