A5044179446- COVID-19 Clinical Research Studies
- Hemoglobinopathies and Related Disorders
- Chronic Kidney Disease and Diabetes
- Renal Diseases and Glomerulopathies
- Iron Metabolism and Disorders
- Long-Term Effects of COVID-19
- Blood groups and transfusion
- Muscle and Compartmental Disorders
- Dialysis and Renal Disease Management
- SARS-CoV-2 and COVID-19 Research
- SARS-CoV-2 detection and testing
- Protein Kinase Regulation and GTPase Signaling
- Acute Kidney Injury Research
- Biomedical Research and Pathophysiology
- Renal and related cancers
- Ion Transport and Channel Regulation
- Potassium and Related Disorders
- Ion channel regulation and function
- Heart Failure Treatment and Management
- Biosensors and Analytical Detection
- Parvovirus B19 Infection Studies
- Acute Myocardial Infarction Research
- Intensive Care Unit Cognitive Disorders
- COVID-19 and Mental Health
- Systemic Lupus Erythematosus Research
King's College London
2014-2024
King's College Hospital NHS Foundation Trust
2011-2024
King's College Hospital
2008-2024
University of London
2024
Dumfries and Galloway Royal Infirmary
2024
University of Nottingham
2023-2024
London School of Hygiene & Tropical Medicine
2024
University Hospitals of Leicester NHS Trust
2023
Vanderbilt University
2023
University of Birmingham
2023
Summary Background and objectives Recent studies evaluated the prevalence of hyperkalemia related risk factors in patients with CKD various stages, but there is limited relevant information predialysis patients. This study aimed to examine associated structured environment a low-clearance clinic. Design, setting, participants, & measurements In cross-sectional fashion over prespecified period 4 months, on serum potassium laboratory variables, comorbidities, medications, dietician input...
Abstract Background Acute kidney injury (AKI) is common among patients hospitalised with COVID-19 and associated worse prognosis. The aim of this study was to investigate the epidemiology, risk factors outcomes AKI in a large UK tertiary centre. Methods We analysed data consecutive adults admitted laboratory-confirmed diagnosis across two sites hospital London, UK, from 1st January 13th May 2020. Results Of 1248 inpatients included, 487 (39%) experienced (51% stage 1, 13% 2, 36% 3). weekly...
Patients receiving hemodialysis are at high risk from coronavirus disease 2019 (COVID-19) and demonstrate impaired immune responses to vaccines. There have been several descriptions of their immunologic severe acute respiratory syndrome 2 (SARS-CoV-2) vaccination, but few studies described the clinical efficacy vaccination in patients on hemodialysis.In a multicenter observational study London population undergoing surveillance PCR testing during period vaccine rollout with BNT162b2 AZD1222,...
Studies have questioned whether renal dysfunction in sickle cell disease is linked to hemolysis-associated vasculopathy. We investigated function and markers of hemolysis a cohort 424 adult African-British patients with disease. While significant associations were found HbSS HbSβ(0) (sickle anemia) without controlling for covariates between hemolytic albuminuria, the not HbSC. Estimated glomerular filtration rate, marker function, correlated significantly reticulocyte count bilirubin. Alpha...
Noncompliance with evidence-based interventions and guidelines contributes to significant variable recurrence progression in patients non-muscle-invasive bladder cancer (NMIBC). The implementation of a quality performance indicator (QPI) programme Scotland's National Health Service (NHS) aimed improve outcomes reduce nationwide variance.
Patients receiving in-center hemodialysis treatment face unique challenges during the coronavirus disease 2019 (COVID-19) pandemic, specifically need to attend for that prevents self-isolation. Dialysis unit attributes and isolation strategies might reduce dialysis center COVID-19 infection rates have not been previously examined.We explored role of variables, including community burden, (size layout), control strategies, on among patients in London, United Kingdom, between March 2, 2020 May...
Assessment in African populations suggest adjustment for ethnicity estimated glomerular filtration rate (eGFR) equations derived from Americans lead to overestimation of GFR and failure determine severity chronic kidney disease (CKD). However, studies Europeans are limited. We aimed assess accuracy eGFR equations, with without compared measured people Black the United Kingdom. Performance MDRD, CKD-EPI (with adjustment), Full Age Spectrum (FAS), revised Lund Malmö (LM Revised), European...
Fibrosis is the pathophysiological hallmark of progressive chronic kidney disease (CKD). The a highly metabolically active organ, and it has been suggested that disruption in its metabolism leads to renal fibrosis. We developed longitudinal mouse model acute injury leading CKD an vitro epithelial mesenchymal transition study changes metabolism, inflammation, Using transcriptomics, metabolic modeling, serum metabolomics, we observed sustained fatty acid dysfunction from early late stages CKD....
Over 214 million students globally have been affected by school closures during the COVID-19 pandemic. To address knowledge gaps on transmission of SARS-CoV-2 delta (B.1.617.2) and omicron (B.1.1.529) variants in educational settings we examined virus schools early childhood education care (ECECs) New South Wales (NSW), Australia relation to mitigation measures, including vaccination.Secondary from children adults with laboratory-confirmed infection who attended a (n = 3170) or ECECs 5800)...
<b><i>Background/Aims:</i></b> Data on the prevalence, treatment and control of hypertension in patients with advanced chronic kidney disease (CKD) are limited. This study aimed to examine above factors a cohort predialysis patients. <b><i>Methods:</i></b> During period 4 months, we recorded information blood pressure (BP), comorbidities, medications related parameters followed up Low-Clearance Clinic our Department. Control rates were...
Uncertainty exists regarding the optimal method to estimate glomerular filtration rate (GFR) for disease detection and monitoring. Widely used GFR estimates have not been validated in British ethnic minority populations.Iohexol measured will be reference against which each estimating equation compared. The equations based upon serum creatinine and/or cystatin C. eGFR-C study has 5 components: 1) A prospective longitudinal cohort of 1300 adults with stage 3 chronic kidney followed years...
ABSTRACT Background Hemodialysis patients are at high risk of Covid-19, though vaccination has significant efficacy in preventing and reducing the severity infection. Little information is available on disease vaccine since dissemination Omicron variant. Methods In a multi-center study, during period epidemic driven by variant, all hemodialysis positive for SARS-CoV-2 were identified. Outcomes analyzed according to predictor variables including status. Risk infection was using Cox...
Abstract Purpose Despite vaccination, many patients remain vulnerable to COVID-19 infection and poorer outcomes, because of underlying health conditions resulting in sub-optimal vaccine responses. This study aims demonstrate whether intranasal niclosamide confers additional protection against above standard preventative measures including vaccination. Methods PROTECT-V (PROphylaxis for paTiEnts at risk infecTion) is a platform trial testing multiple pre-exposure prophylactic agents patients....
Objective After-action reviews (AARs) are used to systematically examine the functions, capabilities and barriers impacting effective pandemic responses. This paper describes methods for lessons learnt from undertaking first formal state-wide AAR of public health response COVID-19 in New South Wales (NSW), Australia. Type program A was applied conducted by Health January 2020 until May 2022. Methods The between March November World Organization ARR approach involved six stages including: (1)...
During the coronavirus disease 2019 (COVID-19) pandemic in 2020, high rates of acute kidney injury (AKI) critically unwell patients are being reported, leading to an increased demand for renal replacement therapy (RRT). Providing RRT this large number is proving challenging, and so alternatives continuous therapies (CRRT) intensive care unit (ICU) needed. Peritoneal dialysis (PD) can be initiated immediately after percutaneous insertion catheter, but there concerns about impact on...