A5060885527- Cardiac, Anesthesia and Surgical Outcomes
- Hemodynamic Monitoring and Therapy
- Blood Pressure and Hypertension Studies
- Dialysis and Renal Disease Management
- Hip and Femur Fractures
- Bone fractures and treatments
- Renal function and acid-base balance
- Respiratory Support and Mechanisms
- Airway Management and Intubation Techniques
- Cardiac Arrest and Resuscitation
- Health Systems, Economic Evaluations, Quality of Life
- Cardiovascular Health and Disease Prevention
- Aortic aneurysm repair treatments
- Orthopedic Surgery and Rehabilitation
- Cardiac Valve Diseases and Treatments
- Heart Failure Treatment and Management
- Mechanical Circulatory Support Devices
- Cardiac Structural Anomalies and Repair
- Musculoskeletal Disorders and Rehabilitation
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Acute Ischemic Stroke Management
- Venous Thromboembolism Diagnosis and Management
- Traumatic Brain Injury and Neurovascular Disturbances
- Electrolyte and hormonal disorders
- Anesthesia and Sedative Agents
York Teaching Hospital NHS Foundation Trust
2014-2025
Keele University
1993-2025
Hull York Medical School
2021-2025
National Health Service
2003-2024
North Yorkshire County Council
2023
University of York
2022
Royal Brompton Hospital
2014-2021
International Society for Peritoneal Dialysis
2020
Newcastle University
2016-2017
York Hospital
2004-2013
The effect of the use coronary-artery bypass surgery without cardiopulmonary and cardiac arrest ("off pump") on graft patency remains uncertain. We undertook a prospective, randomized, controlled study to compare graft-patency rates clinical outcomes in off-pump with conventional, "on-pump" surgery.We randomly assigned 50 patients undergo on-pump grafting 54 surgery. Surgical anesthetic techniques were standardized for both groups. Clinical troponin T levels measured. Three months later,...
Intraoperative hypotension is associated with worse perioperative outcomes for patients undergoing major noncardiac surgery. The Hypotension Prediction Index a unitless number that derived from an arterial pressure waveform trace, and as the increases, risk of occurring in near future increases. We investigated diagnostic ability predicting impending intraoperative comparison to other commonly collected hemodynamic variables.
Background The Hypotension Prediction Index (the index) software is a machine learning algorithm that detects physiologic changes may lead to hypotension. original validation used case control (backward) analysis has been suggested be biased. This study therefore conducted cohort (forward) and compared this the technique. Methods A retrospective of data from previously reported studies was conducted. All were analyzed identically with two different methodologies, receiver operating...
Measurement of outcomes after major abdominal surgery has traditionally focused on mortality, however the low incidence in elective makes this measure a poor comparator. The Postoperative Morbidity Survey (POMS) prospectively assesses short-term morbidity, and may have clinical utility both as core outcome trials quality care. POMS been shown to be valid mixed surgical population, it not studied patients undergoing surgery. This study assessed inter-rater reliability validity...
Background Postherpetic neuralgia remains a difficult problem to treat. A number of therapies have been shown be effective, but some patients intractable pain. Patient The case 76-year-old woman whose pain had resistant standard is described. pattern quantitative sensory testing results for this patient led the authors believe that she an "irritable nociceptor" type pathophysiology. Intervention was instructed apply neat peppermint oil (containing 10% menthol) her skin, resulting in almost...
BackgroundThe perioperative management of antiplatelet therapy in noncardiac surgery patients who have undergone previous percutaneous coronary intervention (PCI) remains a dilemma. Continuing dual (DAPT) may carry risk bleeding, while stopping increase the major adverse cardiovascular events (MACE).MethodsOccurrence Bleeding and Thrombosis during Antiplatelet Therapy In Non-Cardiac Surgery (OBTAIN) was an international prospective multicentre cohort study treatment, MACE, serious bleeding...
Abstract Purpose Despite vaccination, many patients remain vulnerable to COVID-19 infection and poorer outcomes, because of underlying health conditions resulting in sub-optimal vaccine responses. This study aims demonstrate whether intranasal niclosamide confers additional protection against above standard preventative measures including vaccination. Methods PROTECT-V (PROphylaxis for paTiEnts at risk infecTion) is a platform trial testing multiple pre-exposure prophylactic agents patients....
Abstract Background Post operative gastrointestinal dysfunction is a common complication following critical illness. The splanchnic circulation sensitive to changes in volume status and unduly impacted by loss compared other organ systems. A raised Hypotension Prediction Index (HPI) value has been associated with decreased microcirculation flow haemorrhage models at 5% loss. aim of this study was assess whether HPI can detect deficit decrease GI microvascular flow. Methods Ten anaesthetised,...
In Brief BACKGROUND: Dopexamine has been shown to reduce both mortality and morbidity in major surgery when it is used as part of a protocol increase oxygen delivery the perioperative period. A European multicenter study examined use dopexamine patients undergoing abdominal surgery, showing trend toward improved survival reduced complications high-risk receiving low-dose (0.5 μg · kg−1 min−1). uptake at anaerobic threshold (AT) confer significant risk allows objective identification...
Hip fracture is a procedure with high mortality and complication rates, there exists group especially at risk of these outcomes identified by their Nottingham Fracture Score (NHFS). Meta-analysis suggests possible benefit to this patient from intravascular volume optimisation. We investigated whether intraoperative fluid blood pressure optimisation improved complications in group. Patients NHFS ≥ 5 were enrolled into multicentre observer-blinded randomised control trial. allocated either...