A5024237699- Parathyroid Disorders and Treatments
- Lipoproteins and Cardiovascular Health
- COVID-19 Clinical Research Studies
- Cardiovascular Effects of Exercise
- Long-Term Effects of COVID-19
- Cardiomyopathy and Myosin Studies
- Cardiac electrophysiology and arrhythmias
- Galectins and Cancer Biology
- Peptidase Inhibition and Analysis
- Bone health and treatments
- Atherosclerosis and Cardiovascular Diseases
- Peripheral Artery Disease Management
- Venous Thromboembolism Diagnosis and Management
- Cardiac, Anesthesia and Surgical Outcomes
- Magnesium in Health and Disease
- Streptococcal Infections and Treatments
- Vitamin D Research Studies
- Cardiac Health and Mental Health
- RNA Research and Splicing
- Lung Cancer Research Studies
- Atrial Fibrillation Management and Outcomes
- Acute Ischemic Stroke Management
- Acute Myocardial Infarction Research
- Cardiac Arrhythmias and Treatments
- Cardiovascular Function and Risk Factors
Hospital Universitario Fundación Jiménez Díaz
2001-2025
Universidad Autónoma de Madrid
2021-2025
Centro de Investigación Biomédica en Red Diabetes y Enfermedades Metabólicas Asociadas
2024-2025
Spanish Biomedical Research Centre in Physiopathology of Obesity and Nutrition
2024-2025
German Cancer Research Center
2024
Universidad Autónoma de Nuevo León
2022
Hospital Universitario Dr José Eleuterio Gonzalez
2022
Hospital Universitario Severo Ochoa
2009
Hospital Universitario de Getafe
2006
Baylor College of Medicine
1998-2002
Background —Idiopathic dilated cardiomyopathy, of which ≈20% cases are familial (FDCM), is a primary myocardial disorder characterized by ventricular dilatation and impaired systolic function. It common cause heart failure the need for cardiac transplantation. Although 6 chromosomal loci responsible autosomal dominant FDCM have been mapped linkage analysis, none these genes identified. By use candidate-gene approach, actin was identified recently as being cardiomyopathy. Considerable...
Background —Arrhythmogenic right ventricular dysplasia (ARVD), a familial cardiomyopathy occurring with prevalence of 1 in 5000, is characterized by replacement myocytes fatty and fibrous tissue. Clinical manifestations include structural functional abnormalities the ventricle arrhythmias, leading to sudden death rate 2.5% per year. Four loci have been mapped, but no gene has identified as yet. Methods Results —We large family >200 members ARVD segregating an autosomal dominant trait...
Background Familial dilated cardiomyopathy (FDCM) and hypertrophic (FHCM) are the 2 most common forms of primary cardiac muscle diseases. Studies indicate that mutations in sarcomeric proteins responsible for FHCM suggest cytoskeletal cause FDCM. Evidence is evolving, however, such conclusions premature. Methods Results A novel missense mutation troponin T gene was identified by direct sequencing confirmed endonuclease restriction analysis a large family with FDCM we had previously mapped to...
Background. Nuclear factor‐κB (NF‐κB) regulates many genes involved in vascular physiopathology. Angiotensin II (Ang II) participates the pathogenesis of several cardiovascular diseases. In a model atherosclerosis, we have noted NF‐κB activation neointimia lesion that was decreased by angiotensin‐converting enzyme (ACE) inhibitors. However, potential direct effect Ang has not been completely elucidated.
Clinical data indicate that patients with C-reactive protein (CRP) levels higher than 2 mg per liter suffer from persistent inflammation, which is associated high risk of cardiovascular disease (CVD). We determined whether a panel biomarkers CVD could predict recurrent events in low or inflammation and coronary artery (CAD). followed 917 CAD (median 4.59 ± 2.39 years), assessing CRP, galectin-3, monocyte chemoattractant protein-1 (MCP-1), N-terminal fragment brain natriuretic peptide...
A site-specific recombination system that probes the relative probabilities pairs of chromosomal loci collide with one another in living cells budding yeast was used to explore contributions pairing, recombination, synaptonemal complex formation, and telomere clustering close juxtaposition homologous chromosome during meiosis. The level Cre-mediated between a pair loxP sites located at an allelic position on chromosomes 13-fold greater than ectopic positions nonhomologous chromosomes....
<title>Abstract</title> Alterations in plasma levels of the components mineral metabolism (MM) system are related to cardiovascular diseases. However, gender differences whole MM patients with acute coronary syndrome (ACS) have not been reported. Our objective was analyse potential on prognostic role women suffering an ACS as compared men. We included 1,230 and collected clinical data components. Primary outcome a composite ischaemic events, heart failure all-cause mortality. Secondary...
Abstract Introduction Pulmonary embolism (PE) is a common acute cardiovascular syndrome worldwide. Various environmental and genetic factors predispose to PE. Right ventricular (RV) failure considered the cause of death. Risk stratification mandatory for appropriate therapeutic management. According ESC guidelines, intermediate-high risk PE defined as hemodynamic stability, PESI class III–V or sPESI ≥1, RV dysfunction elevated cardiac troponin (Tn) levels. While reperfusion treatment (mainly...
Abstract Background Ventricular arrhythmias (VAs) are complex, recurrent and life-threatening events arising from diverse cardiopathies, with a broad spectrum of presentations. Effective treatment presents significant challenges often necessitates multimodal approach. Although stellate ganglion ablation (SGA) has emerged as promising therapy, manily in electric storm —as acknowledged current guidelines—, it remains positioned at lower tier within clinical algorithms, existing evidence is...
In vitro models have now become a realistic alternative to animal for cardiotoxicity assessment. However, the cost and expertise required implement in electrophysiology systems study cardiac cells pose strong obstacle their widespread use. This presents cost-effective approach forin using fully printed graphene-based microelectrode arrays (pGMEAs) coupled an open-source signal acquisition system. We characterized pGMEAs' electrical properties biocompatibility, observing low impedance values...
Alterations in plasma levels of the components mineral metabolism (MM) system are related to cardiovascular diseases. However, gender differences whole MM patients with acute coronary syndrome (ACS) have not been reported. Our objective was analyse potential on prognostic role women suffering an ACS as compared men. We included 1,230 and collected clinical data components. Primary outcome a composite ischaemic events, heart failure all-cause mortality. Secondary outcomes each component...
BackgroundThe perioperative management of antiplatelet therapy in noncardiac surgery patients who have undergone previous percutaneous coronary intervention (PCI) remains a dilemma. Continuing dual (DAPT) may carry risk bleeding, while stopping increase the major adverse cardiovascular events (MACE).MethodsOccurrence Bleeding and Thrombosis during Antiplatelet Therapy In Non-Cardiac Surgery (OBTAIN) was an international prospective multicentre cohort study treatment, MACE, serious bleeding...
The pathophysiological mechanisms underlying Myocardial Infarction with Non-Obstructive Coronary Artery Disease (MINOCA) are still under debate. Lipoprotein (a) [Lp(a)] has proinflammatory and prothrombotic actions been involved in the pathogenesis of atherosclerosis. However, no previous studies have linked Lp(a) levels probability developing MINOCA. Moreover, relationship between MINOCA plasma other proatherogenic molecules such as Interleukin-18 (IL18) proprotein convertase...
Background: Mineral metabolism (MM), mainly fibroblast growth factor-23 (FGF-23) and klotho, has been linked to cardiovascular (CV) diseases. Cardiac rehabilitation (CR) demonstrated reduce CV events, although its potential relationship with changes in MM is unknown. Methods: We performed a prospective, observational, case-control study, acute coronary syndrome (ACS) patients who underwent CR control (matched by age, gender, left ventricular ejection fraction, diabetes, artery bypass...
Introduction: Type-2 diabetes mellitus (T2DM) is associated with early and severe atherosclerosis. However, few biomarkers can predict cardiovascular events in this population. Methods: We followed 964 patients coronary artery disease (CAD), assessing plasma levels of galectin-3, monocyte chemoattractant protein-1 (MCP-1), N-terminal fragment brain natriuretic peptide (NT-proBNP) at baseline. The secondary outcomes were acute ischemia heart failure or death. primary outcome was the...
There are controversial data on the ability of components mineral metabolism (vitamin D, phosphate, parathormone [PTH], fibroblast growth factor-23 [FGF23], and klotho) to predict cardiovascular events. In addition, it is unknown whether they add any prognostic value other well-known biomarkers.
Familial atrial fibrillation, an autosomal dominant disease, was previously mapped to chromosome 10q22. One of the genes 10q22 region is DLG5, a member MAGUKs (Membrane Associated Gyanylate Kinase) family which mediates intracellular signaling. Only partial cDNA available for DLG5. To exclude potential disease inducing mutations, it necessary obtain complete and genomic sequence gene. The Northern Blot analysis performed using 3' UTR this gene indicated transcript size be about 7.2 KB. Using...
Abnormalities of mineral metabolism (MM) have been related to cardiovascular disorders. There are no reports on the prognostic role MM after an acute coronary syndrome (ACS). We aim assess ACS.
A trial was conducted in naturally-occurring disease to compare the efficacy of treatment with trimethoprim-sulfamethoxazole (TMP-SMZ) oral chloramphenicol. The majority patients treated TMP-SMZ (79%) responded just as well did those chloramphenicol, measured by time disappearance fever after therapy. Seven TMP-SMZ, however, failed respond 11 or more days treatment. Neither levels drug serum nor vitro sensitivity tests isolated $ISalmonella$N could account for slow response these TMP-SMZ.
Abstract Aims Residual congestion at the time of hospital discharge is an important readmission risk factor, and its detection with physical examination usual diagnostic techniques have strong limitations in overweight obese patients. New tools like bioelectrical impedance analysis (BIA) could help to determine when euvolaemia reached. The aim this study was investigate usefulness BIA management heart failure (HF) Methods results Our a single‐centre, single‐blind, randomized controlled trial...
Abstract Thoracic aortic aneurysms and dissections (TAAD) are marked by degenerative changes in the media. Marfan syndrome is most common inherited connective tissue disorder associated with TAAD. While vascular smooth muscle cell (VSMC) metabolism emerging as a targetable driver of aneurysm, surgical interventions remain primary strategy to prevent dissection. Our research indicates that hexosamine biosynthetic pathway (HBP), branch glycolysis, upregulated aortas from Fbn1 C1041G/+ Syndrome...