A5079167381- Parathyroid Disorders and Treatments
- Vitamin D Research Studies
- Magnesium in Health and Disease
- Bone health and treatments
- Bone health and osteoporosis research
- Dialysis and Renal Disease Management
- Cardiovascular Function and Risk Factors
- Heart Failure Treatment and Management
- Genetic Syndromes and Imprinting
- Fibroblast Growth Factor Research
- GDF15 and Related Biomarkers
- Cardiac Valve Diseases and Treatments
- Pharmacological Effects and Toxicity Studies
- Diet and metabolism studies
- Biomedical Research and Pathophysiology
- Pancreatitis Pathology and Treatment
- Adipokines, Inflammation, and Metabolic Diseases
- Biomarkers in Disease Mechanisms
- Chronic Kidney Disease and Diabetes
- Connective tissue disorders research
- Growth Hormone and Insulin-like Growth Factors
- Cardiovascular Disease and Adiposity
- Kawasaki Disease and Coronary Complications
- Thyroid and Parathyroid Surgery
- Galectins and Cancer Biology
Hospital Universitario La Paz
2022-2025
Hospital Central de la Defensa Gómez Ulla
2011-2024
Hospital Universitario Fundación Jiménez Díaz
2013-2014
Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas
2009-2013
Ministerio de Defensa
2011
Vall d'Hebron Hospital Universitari
2008
Background. In chronic kidney disease (CKD) patients, the ability to excrete a phosphate load is impaired. Compensatory increase in parathyroid hormone (PTH) and fibroblast growth factor 23 (FGF23) promote phosphaturia. Serum FGF23 concentration considered an early biomarker of excess high levels have been associated with increased mortality. present study, we evaluated changes plasma after treatment binder lanthanum carbonate patients CKD-3 normal serum concentration. Methods. Eighteen...
Objective Vitamin D and fibroblast growth factor-23 (FGF-23) are related with cardiovascular disorders. We have investigated the relationship of calcidiol (vitamin metabolite) FGF-23 plasma levels incidence adverse outcomes in patients coronary artery disease. Methods Prospective follow-up study 704 outpatients, attending departments Cardiology four hospitals Spain, 6–12 months after an acute event. Baseline calcidiol, FGF-23, parathormone, phosphate were assessed. The outcome was...
Abstract Background Abnormalities of fibroblast growth factor‐23 (FGF‐23) plasma levels predict adverse outcomes in patients with coronary artery disease. However, FGF‐23 has a different behaviour the presence type 2 diabetes mellitus (T2D). We explored whether T2D affects predictive power FGF‐23. Methods In 704 stable disease, FGF‐23, calcidiol, parathormone (PTH) and phosphate were prospectively assessed. The primary outcome was development acute ischemic events (acute syndrome, stroke or...
Alterations in plasma levels of the components mineral metabolism (MM) system are related to cardiovascular diseases. However, gender differences whole MM patients with acute coronary syndrome (ACS) have not been reported. Our objective was analyse potential on prognostic role women suffering an ACS as compared men. We included 1,230 and collected clinical data components. Primary outcome a composite ischaemic events, heart failure all-cause mortality. Secondary outcomes each component...
Background: Mineral metabolism (MM), mainly fibroblast growth factor-23 (FGF-23) and klotho, has been linked to cardiovascular (CV) diseases. Cardiac rehabilitation (CR) demonstrated reduce CV events, although its potential relationship with changes in MM is unknown. Methods: We performed a prospective, observational, case-control study, acute coronary syndrome (ACS) patients who underwent CR control (matched by age, gender, left ventricular ejection fraction, diabetes, artery bypass...
Natriuretic peptides are established biomarkers related to the prognosis of heart failure. New have emerged in field cardiovascular disease. The prognostic value these failure with reduced left ventricular ejection fraction is not well-established. We conducted a prospective, single-centre study, including (July 2019 March 2023) 104 patients being consecutively admitted diagnosis acute decompensation. median follow-up was 23.5 months, during which 20 deaths (19.4%) and 21 readmissions for...
<title>Abstract</title> Alterations in plasma levels of the components mineral metabolism (MM) system are related to cardiovascular diseases. However, gender differences whole MM patients with acute coronary syndrome (ACS) have not been reported. Our objective was analyse potential on prognostic role women suffering an ACS as compared men. We included 1,230 and collected clinical data components. Primary outcome a composite ischaemic events, heart failure all-cause mortality. Secondary...
Al igual a como ocurrió en el año 2011, cuando la Sociedad Española de Nefrología (SEN) publicó adaptación española las guías universales Kidney Disease Initiative Global Outcomes (KDIGO) sobre alteraciones del metabolismo óseo-mineral enfermedad renal crónica (CKD-MBD), este documento contiene una actualización y nuestro medio KDIGO 2017. En campo, al que muchos otros nefrológicos, no se ha podido contestar irrefutablemente muchas cuestiones pendientes aún. Sin embargo, hay duda acerca...
There are controversial data on the ability of components mineral metabolism (vitamin D, phosphate, parathormone [PTH], fibroblast growth factor-23 [FGF23], and klotho) to predict cardiovascular events. In addition, it is unknown whether they add any prognostic value other well-known biomarkers.
Abnormalities of mineral metabolism (MM) have been related to cardiovascular disorders. There are no reports on the prognostic role MM after an acute coronary syndrome (ACS). We aim assess ACS.
A positive calcium balance may contribute to vascular calcification, while a negative increases iPTH. We explored the impact of different dialysate concentrations on bone and mineral metabolism parameters according pre-dialysis serum levels.Fifty-six hemodialysis patients were dialyzed with 3.0 or 2.5 mEq/l [calcium] in crossover study two weeks. Bone metabolites measured prior following session. increased more post-dialysis total ionized than [calcium]. The mildest dialysis-induced changes...
Abnormalities of mineral metabolism and inflammation may affect the cardiovascular system. We have assessed relationship left ventricular hypertrophy (LVH) with metabolism.
Background and Objectives We investigated the relationship of Syntax Score (SS) coronary artery calcification (CAC), with plasma levels biomarkers related to cardiovascular damage mineral metabolism, as there is sparse information in this field. Methods studied 270 patients disease that had an acute syndrome (ACS) six months before. Calcidiol, fibroblast growth factor-23, parathormone, phosphate monocyte chemoattractant protein-1 [MCP-1], high-sensitivity C-reactive protein, galectin-3,...
Sarcopenia y dinapenia son dos términos asociados al envejecimiento que definen respectivamente la pérdida de masa fuerza muscular. En el año 2019, European Working Groupon in Older People (EWGSOP) introdujo algoritmo diagnóstico EWGSOP2 sarcopenia, integra ambos conceptos. Consiste en 4 pasos secuenciales: cribado exploración muscular, evaluación muscular su rendimiento físico; dependiendo estos 3 últimos aspectos sarcopenia se categoriza como probable, confirmada grave respectivamente. A...
Introduction Decreased plasma vitamin D (VD) levels are linked to cardiovascular damage. However, clinical trials have not demonstrated a benefit of VD supplements on left ventricular (LV) remodelling. Anterior ST-elevation acute myocardial infarction (STEMI) is the best human model study effect treatments LV We present proof-of-concept that aims investigate whether improves remodelling in patients with anterior STEMI. Methods and analysis The VITamin Acute Myocardial Infarction (VITDAMI)...
Our purpose was to assess a possible association of inflammatory, lipid and mineral metabolism biomarkers with coronary artery ectasia (CAE) determine this acute atherotrombotic events (AAT). We studied 270 patients who underwent angiography during an syndrome 6 months before. Plasma levels several were assessed, followed median 5.35 (3.88–6.65) years. Two interventional cardiologists reviewed the angiograms, diagnosing CAE according previously published criteria in 23 (8.5%). Multivariate...